Results 31 to 40 of about 36,224 (218)
Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park +8 more
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Regulation of embryonic endochondral ossification by Smurf2 [PDF]
Journal of Orthopaedic Research, 2008 AbstractSmurf2 is an E3 ubiquitin ligase that targets TGF‐β receptor activated Smad2 and Smad3 for the proteasome in primary articular chondrocytes, thus stimulating their hypertrophic differentiation. Comparatively, how Smurf2 functions in growth plate chondrocytes in a developing long bone is an open question.
Qiuqian, Wu +5 more
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Osteochondrogenesis derived from synovial fibroblasts in inflammatory arthritis model
Inflammation and Regeneration, 2020 Rheumatoid arthritis (RA) is characterized by chronic joint inflammation, which forms pannus with bone destruction. Bony ankylosis is also observed following inflammation; however, the mechanism behind this aberrant bone formation in RA had remained ...
Yoko Miura, Satoshi Kanazawa
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Frontiers in Cell and Developmental Biology, 2022 Fracture healing is a complicated, long-term, and multistage repair process. Intermittent administration of parathyroid hormone (PTH) has been proven effective on intramembranous and endochondral bone formation during the fracture healing process ...
Cheng Ma +5 more
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Frontiers in Physiology, 2011 Craniosynostosis, the premature closure of cranial suture, is a pathologic condition that affects 1/2000 live births. Saethre-Chotzen syndrome is a genetic condition characterized by craniosynostosis.
Bjorn eBehr +3 more
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Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects [PDF]
European Cells & Materials, 2014 Grafting bone defects or atrophic non-unions with mesenchymal stromal cells (MSCs)-based grafts is not yet successful. MSC-based grafts typically use undifferentiated or osteogenically differentiated MSCs and regenerate bone through intramembranous ...
J van der Stok +6 more
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The principles of dermal and endochondral ossification [PDF]
The mammalian skull is a complex ossified structure of multiple embryological tissue origins. It is formed from two distinct forms of ossification: intramembranous ossification that produces the flat dermal bones of the calvaria craniofacial region and the mandible, and endochondral ossification that forms the cranial base.\ud \ud I investigated the ...
Gibbs, Sophia
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Avian ResearchThe endochondral ossification of hindlimb is essential to a bird's ability to stand, walk and fly. Most hindlimb is ossified in the embryos before hatching in precocial birds.
Xuan Li, Yuxin Zhang, Hongfeng Zhao
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Chondrocytes in fracture healing: A review of chondrocyte journey
Chinese Medical Journal. Previous studies have confirmed that chondrocytes are derived from mesenchymal stem cells (MSCs) and mature into hypertrophic chondrocytes during endochondral ossification.
Tao Zhang +9 more
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Microorganisms, 2022 To investigate the effect of the maternal gut microbiome on fetal endochondral bone formation, fetuses at embryonic day 18 were obtained from germ-free (GF) and specific-pathogen-free (SPF) pregnant mothers.
Yoko Uchida-Fukuhara +12 more
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