Results 31 to 40 of about 18,079 (225)

Regulation of embryonic endochondral ossification by Smurf2 [PDF]

Journal of Orthopaedic Research, 2008
AbstractSmurf2 is an E3 ubiquitin ligase that targets TGF‐β receptor activated Smad2 and Smad3 for the proteasome in primary articular chondrocytes, thus stimulating their hypertrophic differentiation. Comparatively, how Smurf2 functions in growth plate chondrocytes in a developing long bone is an open question.
Qiuqian, Wu, Meina, Wang, Michael J, Zuscik, Di, Chen, Regis J, O'Keefe, Randy N, Rosier   +5 more
openaire   +2 more sources

Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis

Pharmaceutics, 2021
Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Lee   +8 more
doaj   +1 more source

Factores de diferenciación génica y su futuro en el tratamiento de la osteoporosis: de la adipogénesis a la osteoblastogénesis, ¿del mismo modo y en sentido contrario?

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2018
El presente artículo tiene como objetivo presentar de forma resumida los diferentes factores que están involucrados en la diferenciación y el mantenimiento del fenotipo óseo, en contraste con los factores adipogénicos, cuya expresión determina procesos ...
Pedro Sánchez Márquez, Carlos Arturo Révérend Lizcano   +1 more
doaj   +1 more source

Osteochondrogenesis derived from synovial fibroblasts in inflammatory arthritis model

Inflammation and Regeneration, 2020
Rheumatoid arthritis (RA) is characterized by chronic joint inflammation, which forms pannus with bone destruction. Bony ankylosis is also observed following inflammation; however, the mechanism behind this aberrant bone formation in RA had remained ...
Yoko Miura, Satoshi Kanazawa
doaj   +1 more source

Transcriptional Network Controlling Endochondral Ossification [PDF]

Journal of Bone Metabolism, 2017
Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for the morphological and functional changes in differentiating chondrocytes, are ...
Hata, Kenji, Takahata, Yoshifumi, Murakami, Tomohiko, Nishimura, Riko   +3 more
openaire   +2 more sources

Matrix remodeling during endochondral ossification [PDF]

Trends in Cell Biology, 2004
Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role of
Nathalie, Ortega, Danielle J, Behonick, Zena, Werb   +2 more
openaire   +2 more sources

Exogenous PTH 1-34 Attenuates Impaired Fracture Healing in Endogenous PTH Deficiency Mice via Activating Indian Hedgehog Signaling Pathway and Accelerating Endochondral Ossification

Frontiers in Cell and Developmental Biology, 2022
Fracture healing is a complicated, long-term, and multistage repair process. Intermittent administration of parathyroid hormone (PTH) has been proven effective on intramembranous and endochondral bone formation during the fracture healing process ...
Cheng Ma, Huan Liu, Yifan Wei, He Li, Dengshun Miao, Yongxin Ren   +5 more
doaj   +1 more source

The principles of dermal and endochondral ossification [PDF]

The mammalian skull is a complex ossified structure of multiple embryological tissue origins. It is formed from two distinct forms of ossification: intramembranous ossification that produces the flat dermal bones of the calvaria craniofacial region and the mandible, and endochondral ossification that forms the cranial base.\ud \ud I investigated the ...
Gibbs, Sophia
openaire   +1 more source

Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects [PDF]

European Cells & Materials, 2014
Grafting bone defects or atrophic non-unions with mesenchymal stromal cells (MSCs)-based grafts is not yet successful. MSC-based grafts typically use undifferentiated or osteogenically differentiated MSCs and regenerate bone through intramembranous ...
J van der Stok, MKE Koolen, H Jahr, N Kops, JH Waarsing, H Weinans, OP van der Jagt   +6 more
doaj   +1 more source

Endochondral ossification of hindlimbs in embryonic development of Japanese Quail (Coturnix japonica)

Avian Research
The endochondral ossification of hindlimb is essential to a bird's ability to stand, walk and fly. Most hindlimb is ossified in the embryos before hatching in precocial birds.
Xuan Li, Yuxin Zhang, Hongfeng Zhao
doaj   +1 more source