Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(-/-) mice. [PDF]
PLoS ONE, 2013 During the first month of life, the murine posterior-frontal suture (PF) of the cranial vault closes through endochondral ossification, while other sutures remain patent. These processes are tightly regulated by canonical Wnt signaling.
Björn Behr +2 more
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Craniosynostosis of coronal suture in Twist1+/- mice occurs through endochondral ossification recapitulating the physiological closure of posterior frontal suture [PDF]
Frontiers in Physiology, 2011 Craniosynostosis, the premature closure of cranial suture, is a pathologic condition that affects 1/2000 live births. Saethre-Chotzen syndrome is a genetic condition characterized by craniosynostosis.
Bjorn eBehr +3 more
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Endochondral ossification in vitro is influenced by mechanical bending [PDF]
Bone, 2007 Bone development is influenced by the local mechanical environment. Experimental evidence suggests that altered loading can change cell proliferation and differentiation in chondro- and osteogenesis during endochondral ossification. This study investigated the effects of three-point bending of murine fetal metatarsal bone anlagen in vitro on cartilage ...
Trepczik, Britta +8 more
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3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification [PDF]
Bioactive MaterialsThe harsh microenvironment characterized by avascularity and hypoxia presents a significant challenge for bone regeneration following refractory bone defects.
Yuanqi Ma +10 more
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Endochondral ossification in the damaged joint [PDF]
, 2022 The worldwide burden of knee cartilage damage and OA is rising rapidly, especially in relatively young patients. When damaged, articular cartilage possesses little regenerative capacity. Joint homeostasis and a process called ‘endochondral ossification’ are disturbed which leads to continued joint degeneration. When total knee arthroplasty is performed
Janssen, Maarten Petrus François
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Epidermal growth factor signalling pathway in endochondral ossification: an evidence-based narrative review [PDF]
Annals of Medicine, 2022 , L Mangiavini
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Regenerative Therapy, 2023 Vertebrates form their skeletal tissues from three distinct origins (the neural crest, paraxial mesoderm, and lateral plate mesoderm) through two distinct modes of ossification (intramembranous and endochondral ossification).
Yuki Ikeda +14 more
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The role of computational models in mechanobiology of growing bone
Frontiers in Bioengineering and Biotechnology, 2022 Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on ...
Ester Comellas, Sandra J. Shefelbine
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Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiation. [PDF]
PLoS ONE, 2014 Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in the cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification.
Junyi Liao +16 more
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Failures of Endochondral Ossification in the Mucopolysaccharidoses
Current Osteoporosis Reports, 2020 The mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders characterized by abnormal accumulation of glycosaminoglycans (GAGs) in cells and tissues. MPS patients frequently exhibit failures of endochondral ossification during postnatal growth leading to skeletal deformity and short stature.
Zhirui Jiang +3 more
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