Results 21 to 30 of about 18,120 (213)

Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]

Bone Research
Chondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li, Yiming Xu, Li Zhou, Leilei Chang, Zhou Dan, Yunhe Jiang, Chao Wang, Lianfu Deng, Guoqing Tang   +8 more
doaj   +2 more sources

Role of iRhoms 1 and 2 in Endochondral Ossification [PDF]

International Journal of Molecular Sciences, 2020
Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell–cell interactions in the developing growth plates. Previous studies have uncovered an important role of a disintegrin and metalloprotease 17 (ADAM17) in the normal development of the mineralized zone of hypertrophic ...
Renpeng Fang, Coline Haxaire, Miguel Otero, Samantha Lessard, Gisela Weskamp, David R. McIlwain, Tak W. Mak, Stefan F. Lichtenthaler, Carl P. Blobel   +8 more
openaire   +7 more sources

Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair [PDF]

Scientific Reports
The biological process of fracture repair involves inflammation, vascularization, endochondral ossification, and cartilage production. Long non-coding RNAs (lncRNAs) are essential for the growth and maintenance of the skeleton. In this study, the role of
Qiuyue Sun, Chen Zhang, Bowen Chen, Junyi Liao, Aowen Bao, Chen Zhao, Hong Chen, Dawei He, Wei Huang, Guangming Dai   +9 more
doaj   +2 more sources

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells [PDF]

Genes and Diseases
Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration.
Jing Zou, Chengcheng Du, Senrui Liu, Piao Zhao, Shengqiang Gao, Bowen Chen, Xiangdong Wu, Wei Huang, Zhenglin Zhu, Junyi Liao   +9 more
doaj   +2 more sources

SMN deficiency inhibits endochondral ossification via promoting TRAF6-induced ubiquitination degradation of YBX1 in spinal muscular atrophy [PDF]

Bone Research
Survival of motor neuron (SMN) protein encoded by SMN1 gene, is the essential and ubiquitously expressed protein in all tissues. Prior studies demonstrated that SMN deficiency impaired bone development, but the underlying mechanism of abnormal ...
Zijie Zhou, Xinbin Fan, Taiyang Xiang, Yinxuan Suo, Xiaoyan Shi, Yaoyao Li, Yimin Hua, Lei Sheng, Xiaozhong Zhou   +8 more
doaj   +2 more sources

Impairment of the chondrogenic phase of endochondral ossification in vivo by inhibition of cyclooxygenase-2 [PDF]

European Cells & Materials, 2017
Many studies have reported on the effects of cyclooxygenase-2 (COX-2) inhibition on osteogenesis. However, far less is known about the effects of COX-2 inhibition on chondrogenic differentiation.
MPF Janssen, MMJ Caron, B van Rietbergen, DAM Surtel, LW van Rhijn, TJM Welting, PJ Emans   +6 more
doaj   +4 more sources

Potential Role of Leptin in Endochondral Ossification [PDF]

Journal of Histochemistry & Cytochemistry, 2002
Leptin, a 16-kD circulating hormone secreted mainly by white adipose tissue, is a product of the obese (ob) gene. Leptin acts on human marrow stromal cells to enhance differentiation into osteoblasts and inhibit differentiation into adipocytes. Leptin also inhibits bone formation through a hypothalamic relay.
Keiko, Kume, Kazuhito, Satomura, Sachiko, Nishisho, Eiichiro, Kitaoka, Kouji, Yamanouchi, Satoru, Tobiume, Masaru, Nagayama   +6 more
openaire   +4 more sources

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification [PDF]

Heliyon
Low-grade inflammation and pathological endochondral ossification are key processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide.
Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch   +11 more
doaj   +2 more sources

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid [PDF]

Regenerative Therapy
Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow.
Abhiraj Kesharwani, Shoichiro Tani, Masaki Nishikawa, Yasuyuki Sakai, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Hironori Hojo   +7 more
doaj   +2 more sources

Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification [PDF]

European Cells & Materials, 2011
Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone tissue.
TJM Welting, MMJ Caron, PJ Emans, MPF Janssen, K Sanen, MME Coolsen, L Voss, DAM Surtel, A Cremers, JW Voncken, LW van Rhijn   +10 more
doaj   +3 more sources