Results 11 to 20 of about 18,079 (225)

Brd4 is required for chondrocyte differentiation and endochondral ossification. [PDF]

Bone, 2022
Differentiation of multi-potent mesenchymal stromal cells (MSCs) is directed by the activities of lineage-specific transcription factors and co-factors. A subset of these proteins controls the accessibility of chromatin by recruiting histone acetyl transferases or deacetylases that regulate acetylation of the N-termini of H3 and H4 histone proteins ...
Paradise CR, Galvan ML, Pichurin O, Jerez S, Kubrova E, Dehghani SS, Carrasco ME, Thaler R, Larson AN, van Wijnen AJ, Dudakovic A.   +10 more
europepmc   +4 more sources

Close-to-native bone repair via tissue-engineered endochondral ossification approaches [PDF]

iScience, 2022
Summary: In order to solve the clinical challenges related to bone grafting, several tissue engineering (TE) strategies have been proposed to repair critical-sized defects.
Sara Nadine, Inês J. Fernandes, Clara R. Correia, João F. Mano   +3 more
doaj   +4 more sources

Endochondral Ossification of Chick Embryonic Femora in vitro and on Chorioallantoic Membrane

The Journal of Poultry Science, 2008
We observed angiogenesis and endochondral ossification of the femora of chick embryos in vitro, on chorioallantoic membrane (CAM), and in vivo to clarify the cellular processes of avian endochondral ossification. We found that the inside of the in vitro
Manami Kachi, Toshie Sugiyama, Seiji Kusuhara   +2 more
doaj   +2 more sources

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.

PLoS ONE, 2016
The developing long bone is a model of endochondral ossification that displays the morphological layers of chondrocytes toward the ossification center of the diaphysis.
Lindsay E Laurie, Hiroki Kokubo, Masataka Nakamura, Yumiko Saga, Noriko Funato   +4 more
doaj   +2 more sources

Role of iRhoms 1 and 2 in Endochondral Ossification [PDF]

International Journal of Molecular Sciences, 2020
Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell–cell interactions in the developing growth plates. Previous studies have uncovered an important role of a disintegrin and metalloprotease 17 (ADAM17) in the normal development of the mineralized zone of hypertrophic ...
Renpeng Fang, Coline Haxaire, Miguel Otero, Samantha Lessard, Gisela Weskamp, David R. McIlwain, Tak W. Mak, Stefan F. Lichtenthaler, Carl P. Blobel   +8 more
openaire   +6 more sources

SMN deficiency inhibits endochondral ossification via promoting TRAF6-induced ubiquitination degradation of YBX1 in spinal muscular atrophy [PDF]

Bone Research
Survival of motor neuron (SMN) protein encoded by SMN1 gene, is the essential and ubiquitously expressed protein in all tissues. Prior studies demonstrated that SMN deficiency impaired bone development, but the underlying mechanism of abnormal ...
Zijie Zhou, Xinbin Fan, Taiyang Xiang, Yinxuan Suo, Xiaoyan Shi, Yaoyao Li, Yimin Hua, Lei Sheng, Xiaozhong Zhou   +8 more
doaj   +2 more sources

Impairment of the chondrogenic phase of endochondral ossification in vivo by inhibition of cyclooxygenase-2 [PDF]

European Cells & Materials, 2017
Many studies have reported on the effects of cyclooxygenase-2 (COX-2) inhibition on osteogenesis. However, far less is known about the effects of COX-2 inhibition on chondrogenic differentiation.
MPF Janssen, MMJ Caron, B van Rietbergen, DAM Surtel, LW van Rhijn, TJM Welting, PJ Emans   +6 more
doaj   +3 more sources

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification [PDF]

Heliyon
Low-grade inflammation and pathological endochondral ossification are key processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide.
Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch   +11 more
doaj   +2 more sources

Potential Role of Leptin in Endochondral Ossification [PDF]

Journal of Histochemistry & Cytochemistry, 2002
Leptin, a 16-kD circulating hormone secreted mainly by white adipose tissue, is a product of the obese (ob) gene. Leptin acts on human marrow stromal cells to enhance differentiation into osteoblasts and inhibit differentiation into adipocytes. Leptin also inhibits bone formation through a hypothalamic relay.
Keiko, Kume, Kazuhito, Satomura, Sachiko, Nishisho, Eiichiro, Kitaoka, Kouji, Yamanouchi, Satoru, Tobiume, Masaru, Nagayama   +6 more
openaire   +3 more sources

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid [PDF]

Regenerative Therapy
Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow.
Abhiraj Kesharwani, Shoichiro Tani, Masaki Nishikawa, Yasuyuki Sakai, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Hironori Hojo   +7 more
doaj   +2 more sources