Results 41 to 50 of about 36,224 (218)

Plasma exosome miRNA-26b-3p derived from idiopathic short stature impairs longitudinal bone growth via the AKAP2/ERK1/2 axis

Journal of Nanobiotechnology, 2023
Background Currently, the etiology of idiopathic short stature (ISS) is still unclear. The poor understanding of the molecular mechanisms of ISS has largely restricted this strategy towards safe and effective clinical therapies.
Xijuan Liu, Jinghong Yuan, Zhiwen Wu, Junqiu Zhang, Yunfeng Shen, Jingyu Jia   +5 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Vertebral Development in Paleozoic and Mesozoic Tetrapods Revealed by Paleohistological Data. [PDF]

PLoS ONE, 2016
Basal tetrapods display a wide spectrum of vertebral centrum morphologies that can be used to distinguish different tetrapod groups. The vertebral types range from multipartite centra in stem-tetrapods, temnospondyls, and seymouriamorphs up to ...
Marylène Danto, Florian Witzmann, Nadia B Fröbisch   +2 more
doaj   +1 more source

Regulation of endochondral ossification by transcription factors

Frontiers in Bioscience, 2012
Endochondral ossification is very unique and complex biological event which is associated with skeletal development and tissue partnering. Genetic studies and gene-targeting approaches identified several transcription factors that play important roles in endochondral ossification.
Riko, Nishimura, Kenji, Hata, Koichiro, Ono, Katsuhiko, Amano, Yoko, Takigawa, Makoto, Wakabayashi, Rikako, Takashima, Toshiyuki, Yoneda   +7 more
openaire   +2 more sources

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Influence of Functional Disturbance Osteo (chondro) clasts in Endochondral Ossification [PDF]

, 2006
P(論文)Endochondral ossification is preceded by the vascular invasion into hypertrophic chondrocyte lacunae. Although it has been described that the osteoclasts or chondroclasts are primarily responsible for the breakdown of the transverse septa facing the
9287, ユサ, ジュンコ, 9281, サクライ, ユウコ, ヨコテ, ユウスケ, 9282, 奥山, 典子, 9280, 伊東, 博司, 9285, 櫻井, 裕子, 9286, 9283, 9284, YAMASAKI, Akira, ヤマサキ, アキラ, 遊佐, 淳子, YUSA, Junko, 9278, 9279, 9276, 9277, OKUYAMA, Noriko, 9270, 9271, SAKURAI, Yuuko, 横手, 優介, 9274, 9275, 9272, 9273, オクヤマ, ノリコ, YOKOTE, Yuusuke, ITO, Hiroshi, 山崎, 章, イトウ, ヒロシ   +35 more
core  

Traumatic temporomandibular joint bony ankylosis in growing rats

BMC Oral Health, 2022
Background The pathogenesis of traumatic temporomandibular joint (TMJ) bony ankylosis remains unknown. This study aimed to explore the pathogenesis of traumatic TMJ bony ankylosis in a rat model.
Zhen Ma, Yiming Wang, Yang Xue, Wuyang Zhang, Dengke Li, Yuan Li, Guowei Li, Hongzhi Zhou, Xiangxiang Hu, Tiange Deng, Kaijin Hu   +10 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.

PLoS ONE, 2014
Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts for the regeneration of osseous ...
Eamon J Sheehy, Tatiana Vinardell, Mary E Toner, Conor T Buckley, Daniel J Kelly   +4 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source