Results 41 to 50 of about 18,120 (213)
Characterization of early mouse mesenchymal stem/progenitor cells for generating cartilage and study their role in endochondral ossification [PDF]
, 2016 Mesenchymal stem/ stromal cells (MSCs) isolated from mice have allowed to address some of the major issues that could not be investigated by using human MSCs.
Jaiswal, Sumit
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Regulation of embryonic endochondral ossification by Smurf2 [PDF]
Journal of Orthopaedic Research, 2008 AbstractSmurf2 is an E3 ubiquitin ligase that targets TGF‐β receptor activated Smad2 and Smad3 for the proteasome in primary articular chondrocytes, thus stimulating their hypertrophic differentiation. Comparatively, how Smurf2 functions in growth plate chondrocytes in a developing long bone is an open question.
Qiuqian, Wu +5 more
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park +8 more
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Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2018 El presente artículo tiene como objetivo presentar de forma resumida los diferentes factores que están involucrados en la diferenciación y el mantenimiento del fenotipo óseo, en contraste con los factores adipogénicos, cuya expresión determina procesos ...
Pedro Sánchez Márquez +1 more
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Osteochondrogenesis derived from synovial fibroblasts in inflammatory arthritis model
Inflammation and Regeneration, 2020 Rheumatoid arthritis (RA) is characterized by chronic joint inflammation, which forms pannus with bone destruction. Bony ankylosis is also observed following inflammation; however, the mechanism behind this aberrant bone formation in RA had remained ...
Yoko Miura, Satoshi Kanazawa
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Transcriptional Network Controlling Endochondral Ossification [PDF]
Journal of Bone Metabolism, 2017 Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for the morphological and functional changes in differentiating chondrocytes, are ...
Hata, Kenji +3 more
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The principles of dermal and endochondral ossification [PDF]
The mammalian skull is a complex ossified structure of multiple embryological tissue origins. It is formed from two distinct forms of ossification: intramembranous ossification that produces the flat dermal bones of the calvaria craniofacial region and the mandible, and endochondral ossification that forms the cranial base.\ud \ud I investigated the ...
Gibbs, Sophia
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Matrix remodeling during endochondral ossification [PDF]
Trends in Cell Biology, 2004 Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role of
Nathalie, Ortega +2 more
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Sclerostin silencing promotes endochondral ossification. [PDF]
, 2018 ATDC5 cells with SOST gene silencing (shSOST) were cultured for endochondral ossification. (A) Relative mRNA expressions of SOST, Col2a1, and Sox9 at 2 weeks of culture.
Tomoyuki Saito (68497) +4 more
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Frontiers in Cell and Developmental Biology, 2022 Fracture healing is a complicated, long-term, and multistage repair process. Intermittent administration of parathyroid hormone (PTH) has been proven effective on intramembranous and endochondral bone formation during the fracture healing process ...
Cheng Ma +5 more
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