Results 61 to 70 of about 18,079 (225)

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Incomplete Endochondral Ossification Of The Otic Capsule, A Variation In Children: Evaluation Of Its Prevalence And Extent In Children With And Without Sensorineural Hearing Loss

, 2015
BACKGROUND AND PURPOSE: Endochondral ossification of the otic capsule is a process that continues postnatally; hence, incomplete endochondral ossification is seen as pericochlear hypoattenuation on temporal bone CT scans of children.
Sarac, S., Sanverdi, S. E., Dolgun, A., Ozgen, B.   +3 more
core   +2 more sources

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats

BMJ Open Diabetes Research & Care, 2020
Introduction Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis.
Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue   +15 more
doaj   +1 more source

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, EarlyView.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media is crucial for achieving either uniform or spatially controlled oxygen delivery.
Franziska Alt, Eric Langner, Hans‐Peter Wiesmann, Thomas Wallmersperger, Benjamin Kruppke   +4 more
wiley   +1 more source

Engineering Small-Scale and Scaffold-Based Bone Organs via Endochondral Ossification Using Adult Progenitor Cells

, 2016
Bone development, growth, and repair predominantly occur through the process of endochondral ossification, characterized by remodelling of cartilaginous templates.
Atanas Todorov, Piccinini, Elia, Tonnarelli, Beatrice, Papadimitropoulos, Adam, Beatrice Tonnarelli, Barbero, Andrea, Celeste Scotti, Centola, Matteo, Todorov, Atanas, Andrea Barbero, Scotti, Celeste, Elia Piccinini, Martin, Ivan, Ivan Martin, Adam Papadimitropoulos, Matteo Centola   +15 more
core   +1 more source

Osteogenic Potential of Caspases Related to Endochondral Ossification [PDF]

Journal of Histochemistry & Cytochemistry, 2017
Caspases have functions particularly in apoptosis and inflammation. Increasing evidence indicates novel roles of these proteases in cell differentiation, including those involved in osteogenesis. This investigation provides a complex screening of osteogenic markers affected by pan caspase inhibition in micromass cultures derived from mouse forelimbs ...
Eva Janečková, Petra Bíliková, Eva Matalová   +2 more
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Spatiotemporal assessment of endochondral ossification.

, 2014
Although from different experimental cohorts, the time course of endochondral ossification observed as a gradient of green to red in the right hand case study in (B) can be tied to the spatial gradient of mineralization observed as a gradient from pink ...
Gerald M. Saidel (270446), Melissa L. Knothe Tate (137064), Ulf Knothe (589297), Shannon R. Moore (192565)   +3 more
core   +1 more source