Results 71 to 80 of about 36,224 (218)

Engineering Small-Scale and Scaffold-Based Bone Organs via Endochondral Ossification Using Adult Progenitor Cells

, 2016
Bone development, growth, and repair predominantly occur through the process of endochondral ossification, characterized by remodelling of cartilaginous templates.
Atanas Todorov, Piccinini, Elia, Tonnarelli, Beatrice, Papadimitropoulos, Adam, Beatrice Tonnarelli, Barbero, Andrea, Celeste Scotti, Centola, Matteo, Todorov, Atanas, Andrea Barbero, Scotti, Celeste, Elia Piccinini, Martin, Ivan, Ivan Martin, Adam Papadimitropoulos, Matteo Centola   +15 more
core   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Spatiotemporal assessment of endochondral ossification.

, 2014
Although from different experimental cohorts, the time course of endochondral ossification observed as a gradient of green to red in the right hand case study in (B) can be tied to the spatial gradient of mineralization observed as a gradient from pink ...
Gerald M. Saidel (270446), Melissa L. Knothe Tate (137064), Ulf Knothe (589297), Shannon R. Moore (192565)   +3 more
core   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Runx2 regulates endochondral ossification in condyle during mandibular advancement [PDF]

, 2005
Runx2 is a transcription factor prerequisite for chondrocyte maturation and osteoblast differentiation. We tested the hypothesis that Runx2 is responsible for signaling chondrocyte maturation and endochondral ossification in the condyle during mandibular
Rabie, ABM, Tang, GH
core   +1 more source

HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Joint cartilage defects are difficult to treat due to the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for cartilage repair.
Nian Zhou, Ning Hu, Jun-Yi Liao, Liang-Bo Lin, Chen Zhao, Wei-Ke Si, Zhong Yang, Shi-Xiong Yi, Ting-Xu Fan, Wei Bao, Xi Liang, Xu Wei, Hong Chen, Cheng Chen, Qiang Chen, Xin Lin, Wei Huang   +16 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Detection of hypoxia inducible factors and angiogenic growth factors during foetal endochondral and intramembranous ossification

, 2010
During skeletogenesis, the development of a new vascular network, i.e. angiogenesis, is triggered by hypoxia through the activation of the hypoxia inducible factors (HIFs) HIF-1a and HIF-2a.
Cornillie, Pieter, P. Cornillie, W. De Spiegelaere, De Spiegelaere, Ward, Burvenich, Christian Paul G., W. Van den Broeck, Van Den Broeck, Wim, Casteleyn, Christophe, C. Burvenich, C. Casteleyn   +9 more
core   +1 more source

Incomplete Endochondral Ossification of the Otic Capsule, A Variation in Children: Evaluation of Its Prevalence and Extent in Children with and without Sensorineural Hearing Loss

, 2015
BACKGROUND AND PURPOSE: Endochondral ossification of the otic capsule is a process that continues postnatally; hence, incomplete endochondral ossification is seen as pericochlear hypoattenuation on temporal bone CT scans of children.
Burce Ozgen (18832724), Sarp Sarac (20050743), Nimet Anil Dolgun (20010420), Saziye Sanverdi (20050740)   +3 more
core   +2 more sources

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source