Results 61 to 70 of about 12,394 (186)

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Differences in Cartilage Formed Intramuscularly or in Joint Surface Defects by Syngeneic Rat Chondrocytes Isolated from the Articular-Epiphyseal Cartilage Complex

Cell Transplantation, 1993
Syngeneic rat chondrocytes isolated from the articular-epiphyseal cartilage complex were suspended in hyaluronic acid and transplanted intramuscularly or into joint surface defects. Transplants were fixed in ruthenium hexammonium trichloride and embedded
Stanislaw Moskalewski, Anna Hyc, Tomasz Grzela, Jacek Malejczyk   +3 more
doaj   +1 more source

HISTOCHEMICAL STUDY OF MITOCHONDRIA IN THE FEMUR DEVELOPMENT OF PIGEON EMBRYO (Columba livia ) [PDF]

Basrah Journal of Veterinary Research, 2016
Twenty fertilized eggs of pigeon (Columba livia) embryo were collected from localmarkets and pigeon breeders in Basrah governorate.They incubated in eggs incubator .The studycomprised histochemical description of mitochondria decreasing and increasing in
Khansa M. Jawad, Fawzi S. Mohsen, Abduljabbar R. Huait   +2 more
doaj   +1 more source

Anti‐inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota

Animal Models and Experimental Medicine, EarlyView.
Transcutaneous electrical nerve stimulation (TENS) improved knee osteoarthritis (KOA) in rats by regulating interleukin‐1β (IL‐1β), IL‐6, and IL‐8 expressions and the bone morphogenetic protein 2 (BMP‐2)/transforming growth factor β (TGF‐β) signaling pathway.
Yan Sun, Tong Ma, Ran Chen, Lan Shen, Xun Tang, Zhiqiang Shen, Hongbin Zhao   +6 more
wiley   +1 more source

Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix

Colloids and Surfaces B: Biointerfaces, 2020
Calcified cartilage extracellular matrix (ECM) is a critical interface at the osteochondral junction which plays an important role in maintaining the structural continuity between articular cartilage and subchondral bone. This mineralized network is primarily composed of glycosaminoglycans (GAGs) and collagen type II (col II) and hosts hypertrophic ...
Serdar Korpayev, Özge Toprak, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Ayşe Karakeçili   +5 more
openaire   +3 more sources

Unveiling the role of hypertrophic chondrocytes in abnormal cartilage calcification: insights into osteoarthritis mechanisms

European Cells & Materials
Osteoarthritis (OA) is a chronic degenerative disease that affects the whole joint, especially the knee joint. Its main features include articular cartilage defects and osteophyte formation, and it is common in middle-aged and elderly people.
JP Yao, J Xu, ZN Huo, YP Yi, DM Xu, XF Wang, JJ Shang, Y Huang, YP Weng, XD Zhou   +9 more
doaj   +1 more source

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. [PDF]

PLoS Genetics, 2018
The growth plate mediates bone growth where SOX9 and GLI factors control chondrocyte proliferation, differentiation and entry into hypertrophy. FOXA factors regulate hypertrophic chondrocyte maturation.
Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Ian G Melhado, Shinsuke Ohba, Xinjun He, Yongheng Huang, Cheng Wang, Andrew P McMahon, Ralf Jauch, Danny Chan, Michael Q Zhang, Kathryn S E Cheah   +12 more
doaj   +1 more source

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

, 2009
Objective\ud \ud To investigate the role of matrix metalloproteinase 13 (MMP-13; collagenase 3) in osteoarthritis (OA). \ud \ud Methods\ud \ud OA was surgically induced in the knees of MMP-13-knockout mice and wild-type mice, and mice were compared ...
Barai, A., Fosang, A.J., Thompson, E.W., Burkhardt, D., Smith, S.M., Werb, Z., Shah, M., Little, C.B.   +7 more
core   +1 more source