Results 61 to 70 of about 18,864 (197)

Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]

Precision and Future Medicine, 2023
Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
doaj   +1 more source

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes [PDF]

, 2015
Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in osteoarthritis (OA).
Huang, X., Karperien, H.B.J., Post, J.N., Zhong, L.   +3 more
core   +2 more sources

The regulation of differentiation in mesenchymal stem cells [PDF]

, 2010
Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
core   +1 more source

Mussel-inspired cortical bone-adherent bioactive composite hydrogels promote bone augmentation through sequential regulation of endochondral ossification

Materials Today Bio, 2023
Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation ...
Shuyi Tan, Yonghao Qiu, Huacui Xiong, Chunhui Wang, Yifan Chen, Wangxi Wu, Zhen Yang, Fujian Zhao   +7 more
doaj   +1 more source

Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model [PDF]

, 2010
Current research aims to develop innovative approaches to improve chondral and osteochondral regeneration. The objective of this study was to investigate the regenerative potential of platelet-rich plasma (PRP) to enhance the repair process of a collagen-
Kon, Elizaveta, Filardo, Giuseppe, Delcogliano, Marco, Fini, Milena, Salamanna, Francesca, Giavaresi, Gianluca, Martin, Ivan, Marcacci, Maurilio   +7 more
core   +1 more source

Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review [PDF]

, 2018
Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have ...
Lamplot, Joseph D, Matava, Matthew J, Schafer, Kevin A   +2 more
core   +2 more sources

Induction and prevention of chondrocyte hypertrophy in culture. [PDF]

The Journal of cell biology, 1989
Primary chondrocytes from whole chick embryo sterna can be maintained in suspension culture stabilized with agarose for extended periods of time. In the absence of FBS, the cells remain viable only when seeded at high densities. They do not proliferate at a high rate but they deposit extracellular matrix with fibrils resembling those of authentic ...
P, Bruckner, I, Hörler, M, Mendler, Y, Houze, K H, Winterhalter, S G, Eich-Bender, M A, Spycher   +6 more
openaire   +2 more sources

Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification

Matrix Biology Plus, 2021
The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
doaj   +1 more source

Suppression of mammalian bone growth by membrane transport inhibitors [PDF]

, 2013
Bone lengthening during skeletal growth is driven primarily by the controlled enlargement of growth plate (GP) chondrocytes. The cellular mechanisms are unclear but membrane transporters are probably involved.
Adams, Alper, Amin, Baartscheer, Bancroft, Breur, Brighton, Buckwalter, Bush, Bush, Bush, Bush, Bush, Bush, Cabantchik, Fliegel, Gibson, Hallows, Hannan, Hoffmann, Hunziker, Hunziker, Hwang, Kidd, Kiernan, Liu, Loqman, Malo, Mansfield, Masereel, O'Neill, Okada, Renshaw, Roach, Satoh, Schelling, Shen, Simpkin, Sugimoto, Tattersall, Tattersall, Wang, Wilkins, Wilsman, Wilsman, Wilsman, Wuthier, Wyllie, Yu   +48 more
core   +1 more source

Tyrosine kinases regulate chondrocyte hypertrophy

Osteoarthritis and Cartilage, 2021
Biomaterials & Tissue ...
Ferrao Blanco, M. N. (author), Domenech Garcia, H. (author), Legeai-Mallet, L. (author), van Osch, G.J.V.M. (author)   +3 more
openaire   +3 more sources