Results 71 to 80 of about 12,394 (186)

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting restores physiological cartilage and subchondral bone properties in osteochondral knee defects ‐ An MRI‐based analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study aimed to evaluate the radiological and patient‐reported outcome measures (PROMs) following spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for the treatment of osteochondral defects of the knee.
Stephan Oehme, Benjamin Bartek, Janne Callsen, Jessica Schallock, Tobias Winkler, Thorsten Diekhoff, Tobias Jung, Danko Dan Milinkovic   +7 more
wiley   +1 more source

Transcription Factors in Cartilage Homeostasis and Osteoarthritis

Biology, 2020
Osteoarthritis (OA) is the most common degenerative joint disease, and it is characterized by articular cartilage loss. In part, OA is caused by aberrant anabolic and catabolic activities of the chondrocyte, the only cell type present in cartilage. These
Margot Neefjes, Arjan P. M. van Caam, Peter M. van der Kraan   +2 more
doaj   +1 more source

Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate. [PDF]

PLoS ONE, 2013
Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor 1 (IGF-1), which has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically ...
Werner Schlegel, Adalbert Raimann, Daniel Halbauer, Daniela Scharmer, Susanne Sagmeister, Barbara Wessner, Magdalena Helmreich, Gabriele Haeusler, Monika Egerbacher   +8 more
doaj   +1 more source

Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion

Frontiers in Bioengineering and Biotechnology, 2021
ObjectiveHuman nasal septal chondrocytes (NC) are a promising minimally invasive derivable chondrogenic cell source for cartilage repair. However, the quality of NC-derived cartilage is variable between donors. Coculture of NC with mesenchymal stem cells
Matthew Anderson-Baron, Matthew Anderson-Baron, Yan Liang, Yan Liang, Melanie Kunze, Melanie Kunze, Aillette Mulet-Sierra, Aillette Mulet-Sierra, Martin Osswald, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B. Adesida, Adetola B. Adesida, Adetola B. Adesida   +14 more
doaj   +1 more source

Minced cartilage implantation provides comparable outcomes to autologous chondrocyte implantation (ACI) for knee cartilage lesions: A matched‐pair analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare short‐term patient‐reported outcomes (PROMs) and revision rates between autologous hand‐minced cartilage implantation (MCI) and autologous chondrocyte implantation (ACI) for knee cartilage lesions. Methods All patients undergoing MCI or ACI at a single centre were retrospectively analysed from a prospectively maintained ...
Armin Runer, Louis Leuthard, Luisa Hoheisel, Vincent A. Stadelmann, Stefan Preiss, Gian M. Salzmann, Jakob Hax   +6 more
wiley   +1 more source

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy [PDF]

Development, 2008
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh ...
Kinglun Kingston, Mak, Henry M, Kronenberg, Pao-Tien, Chuang, Susan, Mackem, Yingzi, Yang   +4 more
openaire   +2 more sources

Collagen‐membrane‐covered matrix‐associated chondrocyte implantation improves safety over periosteum‐covered MACI for large knee cartilage defects: A real‐world data analysis in the registry study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This registry study aimed to evaluate the safety and effectiveness of collagen membrane‐covered matrix‐associated autologous chondrocyte implantation (cMACI) versus periosteum‐covered MACI (pMACI) for large knee cartilage defects (Outerbridge III–IV, ≥4 cm²) in the femorotibial and/or patellofemoral joints with a minimum 2‐year follow ...
Yuji Uchio, Ryosuke Kuroda, Yasuo Niki, Katsura Sugawara, Yasuyuki Ishibash   +4 more
wiley   +1 more source

Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

Bone Reports, 2018
There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications
Phillip T. Newton, Meng Xie, Ekaterina V. Medvedeva, Lars Sävendahl, Andrei S. Chagin   +4 more
doaj   +1 more source

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development

, 2007
SummaryChondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program ...
Bassel-Duby, Rhonda, Olson, Eric N., Shelton, John M., Qi, Xiaoxia, Richardson, James A., Kim, Yuri, McAnally, John, Phan, Dillon, Arnold, Michael A., Czubryt, Michael P.   +9 more
core   +1 more source