A homeostatic function of CXCR2 signalling in articular cartilage [PDF]
, 2014 Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen +17 more
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Identification and characterization of up-regulated genes during chondrocyte hypertrophy [PDF]
Developmental Dynamics, 1996 Chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type X collagen, alkaline phosphatase, and matrix metalloproteinases. To analyze further the genetic program associated with chondrocyte hypertrophy, we have employed a modification of the polymerase chain reaction-mediated
M, Nurminskaya, T F, Linsenmayer
openaire +2 more sources
Filamin B Regulates Chondrocyte Proliferation and Differentiation through Cdk1 Signaling [PDF]
, 2014 Humans who harbor loss of function mutations in the actin-associated filamin B (FLNB) gene develop spondylocarpotarsal syndrome (SCT), a disorder characterized by dwarfism (delayed bone formation) and premature fusion of the vertebral, carpal and tarsal ...
Boden, Andrew F. +13 more
core +10 more sources
Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. [PDF]
J Biol Chem, 2018 Yan J +8 more
europepmc +2 more sources
Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. [PDF]
, 1994 Epiphyseal chondrocytes cultured in a medium containing 10% serum may be maintained as three dimensional aggregates and differentiate terminally into hypertrophic cells.
Ballock, RT, Reddi, AH
core
Computational modeling of the mechanical modulation of the growth plate by sustained loading [PDF]
, 2012 This paper presents a computational model that describes the growth of the bone as a function of the proliferation and hypertrophy of chondrocytes in the growth plate. We have included the effects of the mechanical loads on the sizes of the proliferative
Carlos A Narváez-Tovar +1 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Advanced Healthcare Materials, EarlyView.This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source
Factors involved in mandibular condylar growth: an overview [PDF]
, 2014 Although functional appliances have been widely adopted for clinical modulation of mandibular growth for nearly a century, the underlying regulatory mechanism of mandibular condyle growth have been under investigation. Over these years, studies have been
Ren, C, Yang, Y
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Effects of Concanavalin A on Chondrocyte Hypertrophy and Matrix Calcification [PDF]
Journal of Biological Chemistry, 1997 Resting chondrocytes do not usually undergo differentiation to the hypertrophic stage and calcification. However, incubating these cells with concanavalin A resulted in 10-100-fold increases in alkaline phosphatase activity, binding of 1,25(OH)2-vitamin D3, type X collagen synthesis, 45Ca incorporation into insoluble material, and calcium content.
W, Yan +8 more
openaire +2 more sources