Results 91 to 100 of about 109,571 (195)
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose To compare short‐term patient‐reported outcomes (PROMs) and revision rates between autologous hand‐minced cartilage implantation (MCI) and autologous chondrocyte implantation (ACI) for knee cartilage lesions. Methods All patients undergoing MCI or ACI at a single centre were retrospectively analysed from a prospectively maintained ...
Armin Runer +6 more
wiley +1 more source
Tyrosine kinases regulate chondrocyte hypertrophy
Osteoarthritis and Cartilage, 2021 Biomaterials & Tissue ...
Ferrao Blanco, M. N. (author) +3 more
openaire +3 more sources
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose This registry study aimed to evaluate the safety and effectiveness of collagen membrane‐covered matrix‐associated autologous chondrocyte implantation (cMACI) versus periosteum‐covered MACI (pMACI) for large knee cartilage defects (Outerbridge III–IV, ≥4 cm²) in the femorotibial and/or patellofemoral joints with a minimum 2‐year follow ...
Yuji Uchio +4 more
wiley +1 more source
PLOS ONE, 2016 Differentiation of chondrocytes towards hypertrophy is a natural process whose control is essential in endochondral bone formation. It is additionally thought to play a role in several pathophysiological processes, with osteoarthritis being a prominent example.
Kerkhofs, Johan +5 more
openaire +4 more sources
Med Research, EarlyView.This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei +9 more
wiley +1 more source
Factors affecting outcome after autologous chondrocyte implantation for the treatment of osteochondral defects of the knee [PDF]
, 2015 Some studies on autologous chondrocyte implantation (ACI) have demonstrated little benefit over other techniques and few have demonstrated a lasting benefit.
Jaiswal, PK
core
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways
, 2011 During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage.
Noriyuki Tsumaki +6 more
core +1 more source
Mаsseter muscle hypertrophy in dentistry [PDF]
, 2018 Masseter hypertrophy (MH) is rare, asymptomatic condition with unexplained etiology. The main finding is unilateral or bilateral benign enlargement of masseter muscles, which results in a pronounced contour of the face and/or in the angle of the lower ...
Vasileva, Radostina; Medical University of Varna
core +1 more source
Progress in bone tissue engineering biomaterials: Development, challenges, and prospects
VIEW, EarlyView.Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang +7 more
wiley +1 more source