Results 91 to 100 of about 11,550 (158)

Smad4 regulates growth plate matrix production and chondrocyte polarity

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +1 more source

Role of miR-101a in targeting Cox-2 to attenuate chondrocyte hypertrophic differentiation and osteoarthritis progression

Genes and Diseases
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally, often playing critical roles in various biological processes.
Rui Mi, Jinnan Chen, Tianxiang Zhu, Huiqin Bian, Rong Wei, Rushuang Deng, Tiaotiao Han, Qian Wang, Yaojuan Lu, Longwei Qiao, Yuting Liang, Qiping Zheng   +11 more
doaj   +1 more source

CK2.1 Activates Chondrogenesis by Regulation of the p38 Mitogen-Activated Protein Kinase Pathway

Kinases and Phosphatases
Osteoarthritis (OA) remains a challenging disease due to the increased rate of incidence in the older population and the lack of a disease-modifying drug.
Venu Pandit, Luke Fracek, Md Tamzid Hossain Tanim, Aarushi Patel, Daniel Halloran, Anja Nohe   +5 more
doaj   +1 more source

In vitro model of chondrocyte hypertrophy

, 2019
Development of in vitro 2D and 3D models of chondrocyte hypertrophy by using primary human chondrocytes that follow the hypertrophic differentiation in order to mimic this significant stage of osteoarthritis, and thereafter quantification of hypertrophy by both biochemical and phenotypical approaches.
openaire   +1 more source

Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy. [PDF]

Mater Today Bio, 2023
Duan M, Xia S, Liu Y, Pu X, Chen Y, Zhou Y, Huang M, Pi C, Zhang D, Xie J.   +9 more
europepmc   +1 more source

Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. [PDF]

Cells, 2022
Chawla S, Mainardi A, Majumder N, Dönges L, Kumar B, Occhetta P, Martin I, Egloff C, Ghosh S, Bandyopadhyay A, Barbero A.   +10 more
europepmc   +1 more source

miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. [PDF]

J Clin Med, 2023
Huang L, Jin M, Gu R, Xiao K, Lu M, Huo X, Sun M, Yang Z, Wang Z, Zhang W, Zhi L, Meng Z, Ma J, Ma J, Zhang R.   +14 more
europepmc   +1 more source

Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. [PDF]

Cell Death Dis, 2023
Taieb M, Ghannoum D, Barré L, Ouzzine M.   +3 more
europepmc   +1 more source

Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes

Journal of Orthopaedic Surgery and Research
Abstract Purpose This study aimed to evaluate the protective effects of gentiopicroside against lipopolysaccharide-induced chondrocyte inflammation. Methods SW 1353 chondrosarcoma cells were stimulated with LPS (5 μg ...
Longfei Li, Qianqian Fan, Yixuan Zhao, Qian Zhang, Gaofeng Qin, Chen Li, Wei Li   +6 more
openaire   +3 more sources

Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes

FASEB BioAdvances
Osteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang, Yao Sun, Tongtong Chen, Hanqi Wang, Changwei Li, Yong Lu   +5 more
doaj   +1 more source