Results 111 to 120 of about 12,394 (186)

Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study

, 2015
Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei, Tare, Rahul S., Sengers, Bram G., Oreffo, Richard O.C.   +3 more
core   +1 more source

Identification and Characterization of a Unique Chondrocyte Gene Involved in Transition to Hypertrophy

Experimental Cell Research, 1996
The character of differentiating chondrocytes in growing long bones has been defined by altered expression of a limited number of genes. To expand this set we have applied differential display to identify genes expressed in either mineralizing or nonmineralizing chondrocytes.
S D, Reynolds, C, Johnston, P S, Leboy, R J, O'Keefe, J E, Puzas, R N, Rosier, P R, Reynolds   +6 more
openaire   +2 more sources

Smad4 regulates growth plate matrix production and chondrocyte polarity

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +1 more source

Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal
Background Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis.
Megan M. Simonds, Samuel T. Freer, Anne Marie C. Brescia   +2 more
doaj   +1 more source

Factors affecting outcome after autologous chondrocyte implantation for the treatment of osteochondral defects of the knee

, 2015
Some studies on autologous chondrocyte implantation (ACI) have demonstrated little benefit over other techniques and few have demonstrated a lasting benefit.
Jaiswal, PK
core  

The secreted protein WNT5A regulates condylar chondrocyte proliferation, hypertrophy and migration

, 2017
Objective: Our previous study showed that WNT5A, a member of the noncanonical WNT pathway, is involved in interleukin-lbeta induced matrix metalloproteinase expression in temporomandibular joint (TMJ) condylar chondrocytes.
Shi, Ruirui, Ge, Xianpeng, Ruirui Shi, Ma, Xuchen, Xuchen Ma, Xianpeng Ge   +5 more
core   +1 more source

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Journal of Orthopaedic Translation
Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte ...
Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang   +12 more
doaj   +1 more source

miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells

Molecular Therapy: Nucleic Acids, 2019
We investigated the functional role of miR-892b as a novel inhibitor of chondrocyte hypertrophy during TGF-β-mediated chondrogenesis of human mesenchymal stem cells (hMSCs). The expression of miR-892b during TGF-β-mediated chondrogenesis of hMSCs and the
Jong Min Lee, Ji-Yun Ko, Hye Young Kim, Jeong-Won Park, Farshid Guilak, Gun-Il Im   +5 more
doaj   +1 more source

Role of miR-101a in targeting Cox-2 to attenuate chondrocyte hypertrophic differentiation and osteoarthritis progression

Genes and Diseases
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally, often playing critical roles in various biological processes.
Rui Mi, Jinnan Chen, Tianxiang Zhu, Huiqin Bian, Rong Wei, Rushuang Deng, Tiaotiao Han, Qian Wang, Yaojuan Lu, Longwei Qiao, Yuting Liang, Qiping Zheng   +11 more
doaj   +1 more source

Cartilage tissue engineering using pre-aggregated human articular chondrocytes [PDF]

, 2008
In this study, we first aimed at determining whether human articular chondrocytes (HAC) proliferate in aggregates in the presence of strong chondrocyte mitogens.
Farhadi, J., J Farhadi, M Heberer, C Candrian, D Wendt, Wendt, D., A Barbero, Barbero, A., F Wolf, Wolf, F., Martin, I., Candrian, C., Heberer, M., I Martin   +13 more
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