Results 111 to 120 of about 18,864 (197)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p [PDF]

, 2015
microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are essential for normal skeletal development and chondrogenesis in particular.
Akiyama, Albers, Baek, Baraniskin, Bartel, Barter, Berschneider, Bhushan, Bi, Boland, Chiang, Chun, DeLise, Djebali, Dongen, Eberhart, Ebert, Feigin, Friedman, Fu, Furumatsu, Golan, Gradus, Grumolato, Hwang, Jenkins, Kai, Kanamori, Karlsen, Karlsson, Kolben, Korinek, Krol, Laine, Lalevee, Li, Li, Liu, Liu, Lyons, Miyaki, Miyaki, Murdoch, Nakamura, Onyekwelu, Pais, Parikh, Pittenger, Radwan, Roelofs, Rui, Schulz, Smyth, Song, Sorrentino, Staines, Sumiyoshi, Swingler, Tardif, Taylor, Tuddenham, Vonk, Wang, Wang, Xu, Yamashita, Yang, Yang, Yano, Yuan, Zeybel, Zhang, Zhang   +72 more
core   +1 more source

Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix

Colloids and Surfaces B: Biointerfaces, 2020
Calcified cartilage extracellular matrix (ECM) is a critical interface at the osteochondral junction which plays an important role in maintaining the structural continuity between articular cartilage and subchondral bone. This mineralized network is primarily composed of glycosaminoglycans (GAGs) and collagen type II (col II) and hosts hypertrophic ...
Serdar Korpayev, Özge Toprak, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Ayşe Karakeçili   +5 more
openaire   +3 more sources

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro [PDF]

Brazilian Journal of Medical and Biological Research, 2014
Tissue engineering encapsulated cells such as chondrocytes in the carrier matrix have been widely used to repair cartilage defects. However, chondrocyte phenotype is easily lost when chondrocytes are expanded in vitro by a process defined as ...
G.J. Xu, Z.H. Lu, X. Lin, C.W. Lin, L. Zheng, J.M. Zhao   +5 more
doaj   +2 more sources

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

FasL Expression in Articular Discs of Human Temporomandibular Joint and Association with Osteoarthrosis [PDF]

, 2013
Background Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis.
Alanis, Luciana Reis Azevedo, Almeida, Luis Eduardo, Ambros, Viviane, Azevedo, Marina, Camejo, Flavio de Alcantara, Caporal, Karina Sao Thiago, Doetzer, Andrea, Noronha, Lucia, Olandoski, Marcia, Trevilatto, Paula C.   +9 more
core   +2 more sources

Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model

Journal of Anatomy, EarlyView.
Animals were sensitized with mBSA emulsified in CFA/IFA and subsequently received three intra‐articular injections of mBSA into either the TMJ or the knee (once per week). Mechanical hyperalgesia was assessed using electronic von Frey testing after arthritis establishment at 24 h or 7 days following the third intra‐articular injection.
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Delane Viana Gondim   +2 more
wiley   +1 more source

Mandibular condyle: structure properties and growth regulation [PDF]

, 2014
Malocclusion is a developmental condition. In most instances, malocclusion and dentofacial deformity arise from variations in the normal development, and so it must be evaluated against a perspective of natural growth.
Ren, C, Yang, Y
core   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source