Results 101 to 110 of about 109,571 (195)

G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation

Bone & Joint Research
Aims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou, Sung-Yen Lin, Shu-Chun Chuang, Pei-Yin Shih, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang   +6 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Genes and Diseases
Mutation of the MAPK7 gene was related to human scoliosis. Mapk7 regulated the development of limb bones and skulls in mice. However, the role of MAPK7 in vertebral development is still unclear.
Chengzhi Wu, Hengyu Liu, Dongmei Zhong, Xiaoming Yang, Zhiheng Liao, Yuyu Chen, Shun Zhang, Deying Su, Baolin Zhang, Chuan Li, Liru Tian, Caixia Xu, Peiqiang Su   +12 more
doaj   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways [PDF]

, 2006
The transcription factor, Runx2, promotes chondrocyte hypertrophy, whereas parathyroid hormone-related protein (PTHrP) delays this process. To examine whether PTHrP suppresses chondrocyte hypertrophy via Runx2-dependent or -independent pathways, Runx2 ...
Yang, Dehong, Bringhurst, F. Richard, Chung, Ung-Il, Karsenty, Gerard, Kronenberg, Henry M., Guo, Jun   +5 more
core   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Oxygen Consumption Rate‐Defined Phases Couple Metabolism to Matrix Dynamics in Chondrocyte‐Mesenchymal Stromal Cell Co‐Culture

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Oxygen consumption rate‐defined phases couple metabolism to matrix dynamics in chondrocyte‐mesenchymal stromal cell co‐culture. Continuous OCR monitoring reveals three metabolic stages in nasal chondrocyte–MSC pellets that couple oxygen use to matrix programs, with NC‐rich ratios favoring hyaline, GAG‐rich cartilage and MSC‐rich ratios producing ...
Zhiyao Ma, Liam McEachern, Xiaoyi Lan, David Xinzheyang Li, Aahil A. Ansari, Ivan Au, Madeline Barker, Melanie Kunze, Aillette Mulet‐Sierra, Adetola B. Adesida   +9 more
wiley   +1 more source

Epigenetic regulation of chondrocyte differentiation

Japanese Dental Science Review, 2015
Chondrocytes play an essential role in endochondral bone development, which is requisite for mammalian skeletal development. During endochondral bone development, chondrocytes undergo well-organized stages of sequential differentiation, including ...
Kenji Hata, DDS, PhD
doaj   +1 more source

Integrative Transcriptomic Profiling Delineates LTBP4‐Driven Fibroblast Reprogramming Across the Ossification Continuum of the Ligamentum Flavum

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
This study delineates the dynamic transcriptomic landscape of OLF across normal, immature, and mature stages via RNA‐seq. LTBP4 shows progressive downregulation and is validated in external datasets. Single‐cell and spatial transcriptomics identify fibroblasts as the cellular source.
Xiao Zhang, Tengyao Niu, Yulong Zhao, Zhenguo Liu, Wenbo Gu, Donghui Cao, Yanrong Tian, Haifeng Yuan   +7 more
wiley   +1 more source