Results 101 to 110 of about 12,394 (186)

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Genes and Diseases
Mutation of the MAPK7 gene was related to human scoliosis. Mapk7 regulated the development of limb bones and skulls in mice. However, the role of MAPK7 in vertebral development is still unclear.
Chengzhi Wu, Hengyu Liu, Dongmei Zhong, Xiaoming Yang, Zhiheng Liao, Yuyu Chen, Shun Zhang, Deying Su, Baolin Zhang, Chuan Li, Liru Tian, Caixia Xu, Peiqiang Su   +12 more
doaj   +1 more source

PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways

, 2006
The transcription factor, Runx2, promotes chondrocyte hypertrophy, whereas parathyroid hormone-related protein (PTHrP) delays this process. To examine whether PTHrP suppresses chondrocyte hypertrophy via Runx2-dependent or -independent pathways, Runx2 ...
Yang, Dehong, Bringhurst, F. Richard, Chung, Ung-Il, Karsenty, Gerard, Kronenberg, Henry M., Guo, Jun   +5 more
core   +1 more source

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source

Epigenetic regulation of chondrocyte differentiation

Japanese Dental Science Review, 2015
Chondrocytes play an essential role in endochondral bone development, which is requisite for mammalian skeletal development. During endochondral bone development, chondrocytes undergo well-organized stages of sequential differentiation, including ...
Kenji Hata, DDS, PhD
doaj   +1 more source

Species‐specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Cross‐species network analysis identifies CCN1/2 as conserved hubs linking extracellular matrix assembly, growth factor signaling, and mechanosensitive pathways during chondrogenesis, guiding model selection and informing CCN‐targeted cartilage regeneration strategies.
Zhangzheng Wang, Judit Vágó, Roland Takács, Szilárd Póliska, Ee Hyun Kim, Eun‐Jung Jin, Satoshi Kubota, Celina G Kleer, Bernard Perbal, Csaba Matta   +9 more
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Expression and roles of novel chondrocyte hypertrophy associated genes

, 2014
© 2014 Dr. Babatunde Ayobami AyodeleThe majority of bones in mammals are formed through endochondral ossification. In endochondral ossification, a cartilage anlage that serves as the template for the formation and development of the future long bone is ...
AYODELE, BABATUNDE
core  

Abnormal Stress Reduced miR‐330 Supplementation Alleviates Osteoarthritis Progression by Suppressing Osteochondral Catabolism

Aging Cell, Volume 25, Issue 6, June 2026.
Downregulation of miR‐330 under abnormal stress exacerbates catabolism in cartilage and subchondral bone, thereby promoting the progression of osteoarthritis. ABSTRACT Abnormal mechanical stress plays a crucial role in the progression of osteoarthritis (OA). Key factors regulating mechanical response remain to be explored. This study harvested synovium
Luxiang Zou, Kaiwen Yang, Chuyao Wang, Yeke Yu, Xiaoyu Zhang, Chuan Lu, Jieyun Zhao, An Qin, Dongmei He   +8 more
wiley   +1 more source

Standardized Image‐Based Arthroscopic Technique for Hip Synovial Chondromatosis: Long‐Term Patient Outcomes

Orthopaedic Surgery, Volume 18, Issue 6, Page 1223-1232, June 2026.
A clock‐face‐guided, imaging‐based arthroscopic protocol improves surgical orientation and facilitates complete removal of loose bodies in hip synovial chondromatosis, leading to favorable long‐term outcomes. ABSTRACT Objective Arthroscopic surgery is recommended for the treatment of hip synovial chondromatosis, as it allows patients to resume daily ...
Jinxi An, Jianing Yu, Rongzhen Lin, Mingyue Fan, Ziheng Bu, Wei Zhu, Jiachang Hong, Wei Liu, Junchao Huang, Yongjun Hu, Peng Wu   +10 more
wiley   +1 more source

A single-cell 3D dynamic volume control system for chondrocytes

BioTechniques
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang, Yiyao Wang, Yanjun Zhang, Xiaochun Wei, Weiyi Chen, Quanyou Zhang   +5 more
doaj   +1 more source