Results 121 to 130 of about 12,394 (186)

Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation [PDF]

The length of long bones is determined by column formation of proliferative chondrocytes and subsequent chondrocyte hypertrophy in the growth plate during bone development.
Maki, Koichiro, Sunaga, Junko, Yokoyama, Yuka, Adachi, Taiji, Kameo, Yoshitaka   +4 more
core   +1 more source

Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy. [PDF]

Mater Today Bio, 2023
Duan M, Xia S, Liu Y, Pu X, Chen Y, Zhou Y, Huang M, Pi C, Zhang D, Xie J.   +9 more
europepmc   +1 more source

WNT5A Regulates Chondrocyte Differentiation through Differential Use of the CaN/NFAT and IKK/NF-κB Pathways

, 2010
Although genetic evidence demonstrated a requirement for Wnt5a during cartilage development, little is known about the mechanisms underlying Wnt5a-regulated chondrocyte growth and differentiation. We therefore investigated the signaling pathways by which
M. Hicham Drissi, Elizabeth W. Bradley
core   +1 more source

Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. [PDF]

Cells, 2022
Chawla S, Mainardi A, Majumder N, Dönges L, Kumar B, Occhetta P, Martin I, Egloff C, Ghosh S, Bandyopadhyay A, Barbero A.   +10 more
europepmc   +1 more source

Chondrocyte hypertrophy in development and disease

Whereas chondrocyte hypertrophy is a normal feature of skeletal growth, in adult chondrocytes it is associated with osteoarthritis (OA). We propose that collagen II fragments provide signals for hypertrophy in cartilage. The lack of collagen II fragments

core  

Liver X Receptor activation delays chondrocyte hypertrophy during endochondral bone growth

, 2014
SummaryObjectiveActivation of the Liver X Receptor (LXR) has recently been identified as a therapeutic strategy for osteoarthritis (OA). Human OA articular cartilage explants show decreased LXR expression, and LXRβ-null mice display OA-like symptoms. LXR
Beier, F., Sun, M.M.-G.
core   +1 more source

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. [PDF]

Cell Death Dis, 2023
Taieb M, Ghannoum D, Barré L, Ouzzine M.   +3 more
europepmc   +1 more source

Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes

Journal of Orthopaedic Surgery and Research
Abstract Purpose This study aimed to evaluate the protective effects of gentiopicroside against lipopolysaccharide-induced chondrocyte inflammation. Methods SW 1353 chondrosarcoma cells were stimulated with LPS (5 μg ...
Longfei Li, Qianqian Fan, Yixuan Zhao, Qian Zhang, Gaofeng Qin, Chen Li, Wei Li   +6 more
openaire   +3 more sources

miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. [PDF]

J Clin Med, 2023
Huang L, Jin M, Gu R, Xiao K, Lu M, Huo X, Sun M, Yang Z, Wang Z, Zhang W, Zhi L, Meng Z, Ma J, Ma J, Zhang R.   +14 more
europepmc   +1 more source