Results 121 to 130 of about 109,571 (195)

3D printing of cell‐free implants: A promising avenue for cartilage regeneration and joint preservation

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This article explores the potential of 3D‐printed, cell‐free implants or devices for cartilage regeneration. It highlights the benefits of using biomaterial‐driven activation and modulation of ESCPs for endogenous healing of heterogeneous tissues, addressing challenges in implant design, repair mechanisms, and regulatory hurdles to create scalable ...
Liangbin Zhou, Shangsi Chen, Boguang Yang, Yiting Lei, Hegeng Li, Haoyue Luo, Xiaoshuai Wang, Qiongjiao Zeng, Jiahui Lai, Fei Jin, Rocky S. Tuan, Zhong Alan Li   +11 more
wiley   +1 more source

Role of miR-101a in targeting Cox-2 to attenuate chondrocyte hypertrophic differentiation and osteoarthritis progression

Genes and Diseases
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally, often playing critical roles in various biological processes.
Rui Mi, Jinnan Chen, Tianxiang Zhu, Huiqin Bian, Rong Wei, Rushuang Deng, Tiaotiao Han, Qian Wang, Yaojuan Lu, Longwei Qiao, Yuting Liang, Qiping Zheng   +11 more
doaj   +1 more source

Smad4 regulates growth plate matrix production and chondrocyte polarity

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +1 more source

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

SERPINE1 (PAI‐1) Regulation in Mechanotransduction‐Associated Cellular Senescence

Journal of Cellular Biochemistry, Volume 127, Issue 9, September 2026.
ABSTRACT Cellular senescence is a complex biological process characterized by irreversible cell‐cycle arrest and acquisition of the senescence‐associated secretory phenotype (SASP). Beyond biochemical stress, increasing evidence indicates that mechanical cues from the extracellular microenvironment contribute to the regulation of senescence; however ...
Intan Chairun Nisa, Pirawan Chantachotikul, Kei Takahata, Arif Nur Muhammad Ansori, Shinji Deguchi   +4 more
wiley   +1 more source

CK2.1 Activates Chondrogenesis by Regulation of the p38 Mitogen-Activated Protein Kinase Pathway

Kinases and Phosphatases
Osteoarthritis (OA) remains a challenging disease due to the increased rate of incidence in the older population and the lack of a disease-modifying drug.
Venu Pandit, Luke Fracek, Md Tamzid Hossain Tanim, Aarushi Patel, Daniel Halloran, Anja Nohe   +5 more
doaj   +1 more source

In vitro model of chondrocyte hypertrophy

, 2019
Development of in vitro 2D and 3D models of chondrocyte hypertrophy by using primary human chondrocytes that follow the hypertrophic differentiation in order to mimic this significant stage of osteoarthritis, and thereafter quantification of hypertrophy by both biochemical and phenotypical approaches.
openaire   +1 more source

Determination of L-Type Calcium Current in the Primary Hypertrophied Left Ventricular Cardiomyocytes of Hypertrophy Heart Rats/HHR [PDF]

, 2009
Background: The molecular mechanisms responsible for electromechanical derangements found in primary left ventricular (LV) hypertrophy have not been clearly elucidated.
Danes, Vennetia R.
core   +1 more source

Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. [PDF]

Cells, 2022
Chawla S, Mainardi A, Majumder N, Dönges L, Kumar B, Occhetta P, Martin I, Egloff C, Ghosh S, Bandyopadhyay A, Barbero A.   +10 more
europepmc   +1 more source

The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.
UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan   +3 more
wiley   +1 more source