Results 121 to 130 of about 11,550 (158)

Histone deacetylase 4 deletion results in abnormal chondrocyte hypertrophy and premature ossification from collagen type 2α1‑expressing cells. [PDF]

Mol Med Rep, 2020
Du G, Xiang C, Sang X, Wang X, Shi Y, Wang N, Wang S, Li P, Wei X, Zhang M, Gao L, Zhan H, Wei L.   +12 more
europepmc   +1 more source

Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids Prevent Mesenchymal Stromal-Cell-Derived Chondrocyte Hypertrophy. [PDF]

Int J Mol Sci, 2020
Muttigi MS, Kim BJ, Choi B, Han I, Park H, Lee SH.   +5 more
europepmc   +1 more source

Innovative Three-Dimensional Microscopic Analysis of Uremic Growth Plate Discloses Alterations in the Process of Chondrocyte Hypertrophy: Effects of Growth Hormone Treatment. [PDF]

Int J Mol Sci, 2020
Fernández-Iglesias Á, Fuente R, Gil-Peña H, Alonso-Durán L, García-Bengoa M, Santos F, López JM.   +6 more
europepmc   +1 more source

Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features. [PDF]

Sci Rep, 2020
Geurts J, Nasi S, Distel P, Müller-Gerbl M, Prolla TA, Kujoth GC, Walker UA, Hügle T.   +7 more
europepmc   +1 more source

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction. [PDF]

Bone Res, 2019
Lian C, Wang X, Qiu X, Wu Z, Gao B, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.   +14 more
europepmc   +1 more source

Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion. [PDF]

Sci Rep, 2019
Murahashi Y, Yano F, Chijimatsu R, Nakamoto H, Maenohara Y, Amakawa M, Miyake Y, Yamanaka H, Iba K, Yamashita T, Tanaka S, Saito T.   +11 more
europepmc   +1 more source

Mechanobiology of hypertrophic chondrocyte mineralization: Biomechanical regulation and therapeutic implications in skeletal disorders. [PDF]

Mechanobiol Med
Liu Y, Xu G, Shen Y, Fu S, Qin A.
europepmc   +1 more source

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Transcriptional regulators of chondrocyte hypertrophy

Birth Defects Research Part C: Embryo Today Reviews, 2008
AbstractCoordinated transition from proliferation to terminal differentiation and hypertrophy of growth plate chondrocytes is required for normal growth of endochondral bones and thus determines final height in humans. Over the last decades, transcription factors of the Sox and Runx families have been shown to be the central regulators of this process.
Mélina Bellini, Nathalie Berube, Lauren A Solomon   +2 more
exaly   +3 more sources

XBP1S Associates with RUNX2 and Regulates Chondrocyte Hypertrophy [PDF]

Journal of Biological Chemistry, 2012
BMP2 (bone morphogenetic protein 2) is known to activate unfolded protein response signaling molecules, including XBP1S and ATF6. However, the influence on XBP1S and ATF6 in BMP2-induced chondrocyte differentiation has not yet been elucidated. In this study, we demonstrate that BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and directly
Chuanju Liu, Feng-Jin Guo
exaly   +4 more sources