Results 131 to 140 of about 109,571 (195)

Artemotil Attenuates Fibrosis‐Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1‐Related TGF‐β/SMAD2/3 Signalling

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Cartilage fibrosis contributes to extracellular matrix remodelling and structural deterioration during osteoarthritis (OA) progression; however, the molecular regulators involved in this process remain incompletely understood. Stanniocalcin‐1 (STC1) has been implicated in tissue remodelling and fibrosis‐associated signalling, but its role in ...
Guang Zhu, Yang Yang, Ye Ma, Gang Wu, Kuanmin Tian, Xiaoxin He, Rui Wang, Penggang Ma, Zhiqun Tang, Qunhua Jin   +9 more
wiley   +1 more source

Chondrocyte hypertrophy in development and disease

Whereas chondrocyte hypertrophy is a normal feature of skeletal growth, in adult chondrocytes it is associated with osteoarthritis (OA). We propose that collagen II fragments provide signals for hypertrophy in cartilage. The lack of collagen II fragments

core  

Viscoelastic response of cells and the role of actin cytoskeletal remodelling. [PDF]

, 2012
PhDThe mechanical properties of living cells provide useful information on cellular structure and function. In the present study a micropipette aspiration technique was developed to investigate the viscoelastic parameters of isolated articular ...
Pravincumar, Priyanka
core   +1 more source

miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. [PDF]

J Clin Med, 2023
Huang L, Jin M, Gu R, Xiao K, Lu M, Huo X, Sun M, Yang Z, Wang Z, Zhang W, Zhi L, Meng Z, Ma J, Ma J, Zhang R.   +14 more
europepmc   +1 more source

Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. [PDF]

Cell Death Dis, 2023
Taieb M, Ghannoum D, Barré L, Ouzzine M.   +3 more
europepmc   +1 more source

Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes

FASEB BioAdvances
Osteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang, Yao Sun, Tongtong Chen, Hanqi Wang, Changwei Li, Yong Lu   +5 more
doaj   +1 more source

Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. [PDF]

Evid Based Complement Alternat Med, 2022
Lu Y, Zhang C, Jiang S, Yuan F.
europepmc   +1 more source

Estimation of Extracellular Matrix Production Using a Cultured-Chondrocyte-Based Gate Ion-Sensitive Field-Effect Transistor

, 2019
Autologous chondrocytes are generally evaluated by mechanical, histological, and biochemical methods. However, the analyzed data are from discontinuous measurements at an end point, during which living chondrocytes are destroyed and stained. To solve the
Toshiya Sakata (2502937), Toshiya Sakata, Hiroto Satake (7283714), Hiroto Satake   +3 more
core   +1 more source

Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. [PDF]

Int J Mol Sci, 2022
Lin L, Yu Y, Liu K, Jiang Y, Zhou Z.
europepmc   +1 more source

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis. [PDF]

BMC Musculoskelet Disord, 2022
Gu X, Li F, Gao Y, Che X, Li P.
europepmc   +1 more source