Results 131 to 140 of about 11,550 (158)

Morphometric analysis of chondrocyte hypertrophy.

The Journal of Bone & Joint Surgery, 1986
In the hypertrophic zone of the cartilaginous growth plate, chondrocytes enlarge, assume a more spherical shape, and form a population of cells called the hypertrophic chondrocytes. The mechanisms that are involved in the formation of hypertrophic chondrocytes are poorly understood. Cell hypertrophy usually refers to an increase in cell size and volume
J A, Buckwalter, D, Mower, R, Ungar, J, Schaeffer, B, Ginsberg   +4 more
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Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

Annals of the New York Academy of Sciences, 2018
Abstract Articular chondrocytes are quiescent, fully differentiated cells responsible for the homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine‐tuned balance between anabolic and catabolic functions. This balance requires phenotypic stability that is lost in osteoarthritis (OA), a disease
Purva, Singh, Kenneth B, Marcu, Mary B, Goldring, Miguel, Otero   +3 more
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MMP-13 is induced during chondrocyte hypertrophy

Journal of Cellular Biochemistry, 2000
During development, mRNA for matrix metalloproteinase-13 (MMP-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. Using chondrocytes from prehypertrophic cartilage of chick embryo sternae, we have examined the relationship between MMP-13 ...
D'Angelo, Marina, Yan, Z., Nooreyazdan, M., Pacifici, Maurizio, Sarment, D. S., Billings, Paul C., Leboy, Phoebe S.   +6 more
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KLF10 is a modulatory factor of chondrocyte hypertrophy in developing skeleton

Journal of Orthopaedic Research, 2020
AbstractTo define the functional role of Krüppel‐like factor (KLF) 10 as a modulator of chondrocyte hypertrophy in developing skeleton, the developmental features in the long bone of KLF10 knockout (KO) mice were investigated and the mesenchymal stem cells (MSCs) from KLF10 KO mice were characterized regarding chondrogenesis and osteogenesis.
Jong Min Lee, Ji‐Yun Ko, Jeong‐Won Park, Woon Kyu Lee, Sun U. Song, Gun‐Il Im   +5 more
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Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis [PDF]

Cell, 2004
Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Xiangli Yang, John Shelton, Gérard Karsenty   +2 more
exaly   +3 more sources

Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy

Journal of Materials Chemistry B, 2021
The “artificial chondrocytes” that consist of chondrocyte secretome enriched PLGA microparticles with the encapsulation of chondrocytes’ membrane fragments had facilitated chondrogenesis and reduced hypertrophy of BMSCs in vitro and in vivo .
Zizhao Tang, Yan Lu, Shixin Zhang, Jing Wang, Qiguang Wang, Yumei Xiao, Xingdong Zhang   +6 more
openaire   +2 more sources

Hypertrophy and physiological death of equine chondrocytes in vitro

Equine Veterinary Journal, 2007
Summary Reasons for performing study : Equine osteochondrosis results from a failure of endochondral ossification during skeletal growth. Endochondral ossification involves chondrocyte proliferation, hypertrophy and death.
Y A, Ahmed, L, Tatarczuch, C N, Pagel, H M, Davies, M, Mirams, E J, Mackie   +5 more
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Role of polyamines in hypertrophy and terminal differentiation of osteoarthritic chondrocytes

Amino Acids, 2011
Polyamines are naturally occurring, positively charged polycations which are able to control several cellular processes in different cell types, by interacting with negatively charged compounds and structures within the living cell. Functional genomics in rodents targeting key biosynthetic or catabolic enzymes have revealed a series of phenotypic ...
FACCHINI, ANNALISA, Borzì R. M., Olivotto E., Platano D., Pagani S., CETRULLO, SILVIA, FLAMIGNI, FLAVIO   +6 more
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BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base

The International Journal of Developmental Biology, 2003
Defects in the growth and development of the endochondral bones that comprise the cranial base contribute to several craniofacial dysmorphic syndromes. Since Bone Morphogenetic Protein (BMP) signaling regulates chondrocyte differentiation and endochondral ossification in developing long bones, we have tested the hypothesis that BMP signaling also ...
Lillian, Shum, Xibin, Wang, Alex A, Kane, Glen H, Nuckolls   +3 more
openaire   +2 more sources

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

Journal of Cellular Physiology, 2006
AbstractWe investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent avian sarcoma (RCAS) viral over‐expression of Wnt8c and Wnt9a, upregulated type X collagen (col10a1) and Runx2 mRNA expression thereby inducing chondrocyte hypertrophy ...
Yu-Feng, Dong, Do Y, Soung, Edward M, Schwarz, Regis J, O'Keefe, Hicham, Drissi   +4 more
openaire   +2 more sources