Results 81 to 90 of about 12,394 (186)

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Tyrosine kinases regulate chondrocyte hypertrophy

Osteoarthritis and Cartilage, 2021
Biomaterials & Tissue ...
Ferrao Blanco, M. N. (author), Domenech Garcia, H. (author), Legeai-Mallet, L. (author), van Osch, G.J.V.M. (author)   +3 more
openaire   +3 more sources

Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification [PDF]

European Cells & Materials, 2011
Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone tissue.
TJM Welting, MMJ Caron, PJ Emans, MPF Janssen, K Sanen, MME Coolsen, L Voss, DAM Surtel, A Cremers, JW Voncken, LW van Rhijn   +10 more
doaj  

Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

Journal of Nanobiotechnology, 2021
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration.
Shenglong Li, Jie Liu, Siyu Liu, Weijie Jiao, Xiaohong Wang   +4 more
doaj   +1 more source

Blocking chondrocyte hypertrophy in conditional Evc knockout mice does not modify cartilage damage in osteoarthritis

, 2022
Chondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic-like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA-like cartilage lesions, whereas its downregulation prevents articular destruction in mouse models ...
Calatrava-Ferreras, Lucia, Ruiz-Pérez, Victor L., Palencia-Campos, Adrián, Herrero-Beaumont, Gabriel, Lamuedra, Ana, Largo, Raquel, Ruiz-Perez, Víctor Luis, Portal-Núñez, Sergio, Gratal, Paula, Mediero, Aranzazu, Calatrava, Lucía   +10 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Stromal Cell-Derived Factor 1 Regulates the Actin Organization of Chondrocytes and Chondrocyte Hypertrophy

PLoS ONE, 2012
Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic and mesenchymal stem cells. This chemokine regulates the formation of multiple organ systems during embryogenesis. However, its roles in skeletal development remain unclear.
Koichi Murata, Toshiyuki Kitaori, Shinya Oishi, Naoki Watanabe, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Takashi Kasahara, Hideyuki Shibuya, Nobutaka Fujii, Takashi Nagasawa, Takashi Nakamura, Hiromu Ito   +12 more
openaire   +4 more sources

Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation

Cell Proliferation, EarlyView.
Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun, Yun Zhao, Yuqing Du, Yifei Fan, Kai Wang, Xiaoqing Hu   +5 more
wiley   +1 more source

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways

, 2011
During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage.
Noriyuki Tsumaki, Daisuke Ikegami, Haruhiko Akiyama, Takashi Nakamura, Toru Nakano, Akira Suzuki, Hideki Yoshikawa   +6 more
core   +1 more source