Arthritis Research & Therapy, 2020 Background Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies including chondrocyte hypertrophy ...
Na Liu +11 more
doaj +1 more source
Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development [PDF]
Journal of Biological Chemistry, 2018 Jianyun Yan, Jun Hu, Nishat Sultana
exaly +2 more sources
The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]
, 2011 Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Matthias F. Pietschmann +13 more
core +1 more source
Tackling chondrocyte hypertrophy with multifunctional nanoparticles [PDF]
Gene Therapy, 2016 Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1, 2 OA is a collection of different phenotypic sub-types involving different relative contributions of the stressors and pathogenic pathways that trigger and drive, respectively, disease development (Figure
BOTTINI, MASSIMO +3 more
openaire +2 more sources
A critical bioenergetic switch is regulated by IGF2 during murine cartilage development
Communications Biology, 2022 Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.
Judith M. Hollander +8 more
doaj +1 more source
Induction and prevention of chondrocyte hypertrophy in culture. [PDF]
The Journal of cell biology, 1989 Primary chondrocytes from whole chick embryo sterna can be maintained in suspension culture stabilized with agarose for extended periods of time. In the absence of FBS, the cells remain viable only when seeded at high densities. They do not proliferate at a high rate but they deposit extracellular matrix with fibrils resembling those of authentic ...
Bruckner P +6 more
openaire +3 more sources
The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]
, 2007 Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C +7 more
core +1 more source
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]
, 2011 Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P. +19 more
core +1 more source
Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
doaj +1 more source
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. [PDF]
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy. Using multiple mouse genetics models, we demonstrate in vivo that HDAC4 is required for the
Nishimori S +7 more
europepmc +3 more sources