Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
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WISP3 - IGF1 interaction regulates chondrocyte hypertrophy [PDF]
Journal of Cell Science, 2013 WISP3 (Wnt Induced Secreted Protein 3) is a multi-domain protein of mesenchymal origin. Mutations in several domains of WISP3 cause PPRD (Progressive Pseudo Rheumatoid Dysplasia), which is associated with cartilage loss and restricted skeletal development.
Srinivasa Rao, Repudi +2 more
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Regulating the Regulators of Chondrocyte Hypertrophy [PDF]
Journal of Bone and Mineral Research, 1999 THE DEVELOPMENT, growth, and maintenance of a functional skeleton relies on the existence of several different types of chondrocytes with markedly different fates. The articular chondrocytes on the surface of joints are expected to persist throughout life, producing extracellular matrix components which provide a cushion to distribute load on bone at ...
S W, Volk, P S, Leboy
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The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. [PDF]
PLoS ONE, 2009 Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling.
Xizhi Guo +3 more
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Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy [PDF]
Biochemical and Biophysical Research Communications, 2003 Thyroid hormones exert a profound effect on development, growth, and metabolism of skeleton. In the present study, we evaluated the effects of thyroxine (T4) and growth hormone (GH) on the terminal differentiation of rib growth plate chondrocytes in three-dimensional pellet culture.
Yasunori, Okubo, A Hari, Reddi
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Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]
, 2020 Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro +67 more
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The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development. [PDF]
Bone Joint Res, 2020 Chen Z +6 more
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Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis. [PDF]
PLoS ONE, 2015 The Integrin β1 family is the major receptors of the Extracellular matrix (ECM), and the synthesis and degradation balance of ECM is seriously disrupted during Osteoarthritis (OA).
David Garciadiego-Cázares +5 more
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Tackling chondrocyte hypertrophy with multifunctional nanoparticles [PDF]
Gene Therapy, 2016 Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1, 2 OA is a collection of different phenotypic sub-types involving different relative contributions of the stressors and pathogenic pathways that trigger and drive, respectively, disease development (Figure
BOTTINI, MASSIMO +3 more
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Arthritis Research & Therapy, 2020 Background Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies including chondrocyte hypertrophy ...
Na Liu +11 more
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