Results 41 to 50 of about 109,571 (195)

Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis. [PDF]

PLoS ONE, 2015
The Integrin β1 family is the major receptors of the Extracellular matrix (ECM), and the synthesis and degradation balance of ECM is seriously disrupted during Osteoarthritis (OA).
David Garciadiego-Cázares, Hilda I Aguirre-Sánchez, René F Abarca-Buis, Juan B Kouri, Cristina Velasquillo, Clemente Ibarra   +5 more
doaj   +1 more source

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway

Arthritis Research & Therapy, 2020
Background Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies including chondrocyte hypertrophy ...
Na Liu, Dejie Fu, Junjun Yang, Pingju Liu, Xiongbo Song, Xin Wang, Rui Li, Zhenlan Fu, Jiajia Chen, Xiaoyuan Gong, Cheng Chen, Liu Yang   +11 more
doaj   +1 more source

Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. [PDF]

PLoS ONE, 2009
The axial and appendicular skeleton of vertebrates develops by endochondral ossification, in which skeletogenic tissue is initially cartilaginous and the differentiation of chondrocytes via the hypertrophic pathway precedes the differentiation of ...
Hui Zhu, Andrew J Bendall
doaj   +1 more source

XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy. [PDF]

Journal of Biological Chemistry, 2012
BMP2 (bone morphogenetic protein 2) is known to activate unfolded protein response signaling molecules, including XBP1S and ATF6. However, the influence on XBP1S and ATF6 in BMP2-induced chondrocyte differentiation has not yet been elucidated. In this study, we demonstrate that BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and directly
Yanna, Liu, Jinghua, Zhou, Wenjun, Zhao, Xiangzhu, Li, Rong, Jiang, Chuanju, Liu, Feng-Jin, Guo   +6 more
openaire   +3 more sources

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]

, 2011
Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Matthias F. Pietschmann, Isa Feist-Pagenstert, Peter E. Müller, Volkmar Jansson, Horng, Annie, Müller, Peter E., Thomas R. Niethammer, Feist-Pagenstert, Isa, Jansson, Volkmar, Mehmet F. Gülecyüz, Pietschmann, Matthias F., Niethammer, Thomas R., Gülecyüz, Mehmet F., Annie Horng   +13 more
core   +1 more source

Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for Osteoarthritis [PDF]

, 2021
Osteoarthritis (OA) is a major health problem worldwide that affects the joints and causes severe disability. It is characterized by pain and low-grade inflammation. However, the exact pathogenesis remains unknown and the therapeutic options are limited.
Legeai-Mallet, L. (author), Ferrao Blanco, M. N. (author), Legeai-Mallet, L., van Osch, G.J.V.M., H. (Heura) Domenech Garcia, Ferrao Blanco, M. N., L. Legeai-Mallet, M.N. (Mauricio) Ferrao Blanco, G.J.V.M. (Gerjo) van Osch, Domenech Garcia, H., van Osch, G.J.V.M. (author), Domenech Garcia, H. (author), van Osch, G. J.V.M.   +12 more
core   +3 more sources

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia [PDF]

, 2000
Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C, Lester, D, Thorp, B H, Botman, M, Farquharson, C; id_orcid, Thorp, B.H, Jefferies, D, Whitehead, C.C, Houston, B, Whitehead, C C   +9 more
core   +1 more source

A critical bioenergetic switch is regulated by IGF2 during murine cartilage development

Communications Biology, 2022
Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.
Judith M. Hollander, Lingyun Li, Miraj Rawal, Si Kun Wang, Yue Shu, Ming Zhang, Heber C. Nielsen, Clifford J. Rosen, Li Zeng   +8 more
doaj   +1 more source

Induction and prevention of chondrocyte hypertrophy in culture. [PDF]

The Journal of cell biology, 1989
Primary chondrocytes from whole chick embryo sterna can be maintained in suspension culture stabilized with agarose for extended periods of time. In the absence of FBS, the cells remain viable only when seeded at high densities. They do not proliferate at a high rate but they deposit extracellular matrix with fibrils resembling those of authentic ...
Bruckner P, Hörler I, Mendler M, Houze Y, Winterhalter KH, Eich-Bender SG, Spycher MA   +6 more
openaire   +3 more sources

The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]

, 2007
Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C, Miner, JN, Farquharson, C; id_orcid, Owen, H C, Miner, J N, Ahmed, S F, Ahmed, SF, Owen, HC   +7 more
core   +1 more source