The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression [PDF]
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression of OA.
Yeri Alice Rim, Ji Hyeon Ju, Yoojun Nam
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Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy [PDF]
Frontiers in SurgeryBackgroundThis study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative and comprehensive overview of the current research status and emerging trends in this field ...
Jiajin Fang, Jiajin Fang, Shuai Wang
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Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis [PDF]
Stem Cells Translational Medicine, 2020 Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng +9 more
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The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy [PDF]
Journal of Inflammation Research, 2022 Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z +10 more
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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization [PDF]
Genes and DiseasesCartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan +14 more
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans [PDF]
Bone ResearchOsteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang +21 more
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M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis [PDF]
Journal of NanobiotechnologyOsteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified.
Yufan Qian +6 more
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The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation [PDF]
Bone Reports, 2017 Chondrocyte hypertrophy makes important contributions to bone development and growth. We have investigated a number of novel cartilage genes identified in a recent transcriptomic study to determine whether they are differentially expressed between ...
Babatunde A. Ayodele +3 more
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Chondrocytes in fracture healing: A review of chondrocyte journey [PDF]
Chinese Medical Journal. Previous studies have confirmed that chondrocytes are derived from mesenchymal stem cells (MSCs) and mature into hypertrophic chondrocytes during endochondral ossification.
Tao Zhang +9 more
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The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development [PDF]
Bone and Joint Research, 2020 Xiaochun Wei, Lei Wei
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