The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation [PDF]
npj Regenerative Medicine, 2022 During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to joint cavities where hypertrophic differentiation and endochondral ...
Michael Chau +9 more
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis [PDF]
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park +8 more
doaj +4 more sources
Suppressing Chondrocyte Hypertrophy to Build Better Cartilage [PDF]
Bioengineering, 2023 Current clinical strategies for restoring cartilage defects do not adequately consider taking the necessary steps to prevent the formation of hypertrophic tissue at injury sites.
Christian Shigley +4 more
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DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression [PDF]
Genes and Diseases, 2023 Osteoarthritis (OA) has been considered non-reversible as articular cartilage wears down with limited repair capacity. Enhanced chondrocyte hypertrophy and increased type X collagen gene (COL10A1) expression have been associated with OA.
Jinnan Chen +12 more
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Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis [PDF]
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
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The regulatory significance of chondrocyte hypertrophy in maintaining chondrocyte homeostasis, regeneration and repair [PDF]
Future Science OAChondrocyte hypertrophy is a pivotal biological process in skeletal development and disease progression, with its precise regulation being essential for maintaining cartilage homeostasis and promoting tissue repair.
Jingxin Li +8 more
doaj +2 more sources
Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]
Bone ResearchChondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li +8 more
doaj +2 more sources
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression [PDF]
npj Regenerative Medicine, 2021 Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park +6 more
doaj +2 more sources
Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy [PDF]
Frontiers in SurgeryBackgroundThis study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative and comprehensive overview of the current research status and emerging trends in this field ...
Jiajin Fang, Jiajin Fang, Shuai Wang
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Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration [PDF]
Bone & Joint ResearchAims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remains elusive.
Yan Xiao +8 more
doaj +2 more sources