Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis [PDF]
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Dalong Dong, Guang-Zhen Jin
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis [PDF]
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Soo-Hong Lee +2 more
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Suppressing Chondrocyte Hypertrophy to Build Better Cartilage [PDF]
Bioengineering, 2023 Current clinical strategies for restoring cartilage defects do not adequately consider taking the necessary steps to prevent the formation of hypertrophic tissue at injury sites.
Christian Shigley +4 more
doaj +5 more sources
DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression [PDF]
Genes and Diseases, 2023 Osteoarthritis (OA) has been considered non-reversible as articular cartilage wears down with limited repair capacity. Enhanced chondrocyte hypertrophy and increased type X collagen gene (COL10A1) expression have been associated with OA.
Longwei Qiao +2 more
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The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation [PDF]
npj Regenerative Medicine, 2022 During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to joint cavities where hypertrophic differentiation and endochondral ...
Michael Chau +9 more
doaj +4 more sources
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression [PDF]
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression of OA.
Yeri Alice Rim, Ji Hyeon Ju, Yoojun Nam
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The regulatory significance of chondrocyte hypertrophy in maintaining chondrocyte homeostasis, regeneration and repair [PDF]
Future Science OAChondrocyte hypertrophy is a pivotal biological process in skeletal development and disease progression, with its precise regulation being essential for maintaining cartilage homeostasis and promoting tissue repair.
Jingxin Li +8 more
doaj +3 more sources
Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy [PDF]
Frontiers in SurgeryBackgroundThis study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative and comprehensive overview of the current research status and emerging trends in this field ...
Jiajin Fang, Jiajin Fang, Shuai Wang
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Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis [PDF]
Stem Cells Translational Medicine, 2020 Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Mian Wang +2 more
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A controlled release bupivacaine-alginate construct: Effect on chondrocyte hypertrophy conversion [PDF]
Osteoarthritis and Cartilage Open, 2020 Objective: Osteoarthritis is a degenerative disease of the joint, affecting over 30 million people in the US1. A key characteristic of OA is chondrocyte hypertrophy, characterized by chondrocyte changes to a more rounded and osteoblastic phenotype ...
Ileana Marrero - Berrios +2 more
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