Results 21 to 30 of about 76,519 (202)

Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]

, 2011
Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P., Chowdhury, T.T., Salter, Donald M, Ramachandran, Manoj, Salter, DM, Chowdhury, TT, Ramachandran, M., Ramachandran, M, Dan L Bader, Achan, Prim, Salter, D.M., Tina T Chowdhury, Bader, Dan L, Bader, DL, Prim Achan, Donald M Salter, Chowdhury, Tina T, Bader, Dan L., Manoj Ramachandran, Achan, P   +19 more
core   +1 more source

Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data

Animals, 2023
Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear.
Haoyuan Zhang, Pu Yang, Chengli Liu, Yuehui Ma, Yanguo Han, Yan Zeng, Yongfu Huang, Yongju Zhao, Zhongquan Zhao, Xiaohong He, Guangxin E   +10 more
doaj   +1 more source

Clinical and cost-effectiveness of autologous chondrocyte implantation for cartilage defects in knee joints : systematic review and economic evaluation [PDF]

, 2005
Objective: To support a review of the guidance issued by the National Institute for Health and Clinical Excellence (NICE) in December 2000 by examining the current clinical and cost-effectiveness evidence on autologous cartilage transplantation ...
C Clar, P Jobanputra, N Waugh, Lamb, J. (John D.), Clar, C., Bain, L. (Lynda), Jobanputra, Paresh, L Bain, McIntyre, Linda, J Lamb, Cummins, E. (Ewen), E Cummins, L McIntyre, Waugh, Norman, Thomas, Sian, S Thomas   +15 more
core   +1 more source

Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano
Shuai Wu, Zhiguo Kai, Dong Wang, Lina Tao, Peng Zhang, Dawei Wang, Dongxing Liu, Shui Sun, Jian Zhong   +8 more
doaj   +1 more source

Potential Joint Protective and Anti-Inflammatory Effects of Integrin α_vβ₃ in IL-1β-Treated Chondrocytes Cells

Biomedicines, 2023
In osteoarthritis (OA), the articular cartilage covering the articular surface of the bone wears out, exposing the subchondral bone, and the synovial membrane surrounding the joint becomes inflamed, causing pain and deformity.
Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Hyun Wook Kim, Je Kyung Seong, Meejung Ahn, Kwang Il Park, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim   +11 more
doaj   +1 more source

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Cell Reports, 2016
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng, Ailing Wu, Pikshan Li, Gang Li, Ling Qin, Hai Song, Kinglun Kingston Mak   +6 more
doaj   +1 more source

Long non-coding RNA LINC00265 promotes proliferation, apoptosis, and inflammation of chondrocytes in osteoarthritis by sponging miR-101-3p

Autoimmunity, 2021
Long non-coding RNAs (lncRNAs) play a part in a wide variety of diseases, including osteoarthritis (OA). This study was designed to investigate the biological role of lncRNA LINC00265 in OA and its underlying mechanisms.
Hanlin Zou, Chunde Lu, Jianjun Qiu
doaj   +1 more source

CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis

Bone & Joint Research, 2022
Aims Circular RNA (circRNA) S-phase cyclin A-associated protein in the endoplasmic reticulum (ER) (circSCAPER, ID: hsa_circ_0104595) has been found to be highly expressed in osteoarthritis (OA) patients and has been associated with the severity of OA ...
Zhaxi Luobu, Lei Wang, Dahai Jiang, Tao Liao, Ciren Luobu, Luosong Qunpei   +5 more
doaj   +1 more source

Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Antioxidants, 2020
Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle ...
Feng-Sheng Wang, Chung-Wen Kuo, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Huei-Jing Ke, Pei-Chen Kuo, Chin-Huei Lee, Jian-Ching Wu, Wen-Bin Lu, Ming-Hong Tai, Holger Jahr, Wei-Shiung Lian   +12 more
doaj   +1 more source

The Elusive Origin of Atherosclerotic Plaque Calcification

Frontiers in Cell and Developmental Biology, 2021
It has been known for decades or even centuries that arteries calcify as they age. Vascular calcification probably affects all adults, since virtually all have atherosclerotic plaques: an accumulation of lipids, inflammatory cells, necrotic debris, and ...
Emmanuelle Canet-Soulas, Laurence Bessueille, Laura Mechtouff, Laura Mechtouff, David Magne   +4 more
doaj   +1 more source