Results 21 to 30 of about 118,322 (313)
Physiological Reports, 2020 Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue +3 more
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Characterisation of Growth Plate Dynamics in Murine Models of Osteoarthritis
Frontiers in Endocrinology, 2021 The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models of osteoarthritis, to understand whether abnormalities in these dynamics are associated with osteoarthritis development. 8-week-old C57BL/6 male mice
Hasmik J. Samvelyan +8 more
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Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
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Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis
Biomedicines, 2023 Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients.
Gyeong Min Kim +8 more
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The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes [PDF]
Archives of Biological Sciences, 2020 MiR-3085-3p was shown to play a crucial role in cartilage biology, with potential impacts in osteoarthritis (OA). Insight into this miRNA function could be of practical importance for future miRNA-based therapy, however, little is known regarding the ...
Le Linh T.T. +2 more
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Ochronotic Chondropathy: A Case Report
Biomedicines, 2023 Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman +4 more
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Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data
Animals, 2023 Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear.
Haoyuan Zhang +10 more
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Chondrocytes in fracture healing: A review of chondrocyte journey. [PDF]
Chin Med J (Engl)Abstract Previous studies have confirmed that chondrocytes are derived from mesenchymal stem cells (MSCs) and mature into hypertrophic chondrocytes during endochondral ossification. This maturation is followed by apoptosis, which induces vascular invasion, cartilage matrix degradation, and osteoblast differentiation.
Zhang T +8 more
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Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Journal of Cellular and Molecular Medicine, 2020 Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao +5 more
semanticscholar +1 more source
A Preliminary Study of Human Amniotic Membrane as a Potential Chondrocyte Carrier [PDF]
Malaysian Orthopaedic Journal, 2009 PURPOSE: To investigate the feasibility of using processed human amniotic membrane (HAM) to support the attachment and proliferation of chondrocytes in vitro which in turn can be utilised as a cell delivery vehicle in tissue engineering applications.
L Boo +5 more
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