Results 21 to 30 of about 70,223 (315)
Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data
Animals, 2023 Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear.
Haoyuan Zhang +10 more
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Biomedicines, 2023 In osteoarthritis (OA), the articular cartilage covering the articular surface of the bone wears out, exposing the subchondral bone, and the synovial membrane surrounding the joint becomes inflamed, causing pain and deformity.
Hun Hwan Kim +11 more
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Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]
, 2007 The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Candrian, Christian +7 more
core +1 more source
Metaplasia of Chondrocytes into Osteoblasts
Folia Biologica, 2006 Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H, Włodarski +2 more
openaire +2 more sources
Cell Reports, 2016 Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng +6 more
doaj +1 more source
Autoimmunity, 2021 Long non-coding RNAs (lncRNAs) play a part in a wide variety of diseases, including osteoarthritis (OA). This study was designed to investigate the biological role of lncRNA LINC00265 in OA and its underlying mechanisms.
Hanlin Zou, Chunde Lu, Jianjun Qiu
doaj +1 more source
CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis
Bone & Joint Research, 2022 Aims Circular RNA (circRNA) S-phase cyclin A-associated protein in the endoplasmic reticulum (ER) (circSCAPER, ID: hsa_circ_0104595) has been found to be highly expressed in osteoarthritis (OA) patients and has been associated with the severity of OA ...
Zhaxi Luobu +5 more
doaj +1 more source
Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice [PDF]
, 2020 Runx2 is required for chondrocyte proliferation and maturation. In the search of Runx2 target genes in chondrocytes, we found that Runx2 up-regulated the expression of hematopoietic cell kinase (Hck), which is a member of the Src tyrosine kinase family ...
Sakane, Chiharu +13 more
core +1 more source
Antioxidants, 2020 Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle ...
Feng-Sheng Wang +12 more
doaj +1 more source
Investigating the causes of chondrocyte death in septic arthritis [PDF]
, 2020 Septic arthritis is a feared disease that can lead to the destruction of joints and result in significant morbidity. It is caused by an infection within a joint and up to 65% of cases are secondary to Staphylococcus aureus.
Clement, Rhys Gareth Ellis
core +1 more source