Results 61 to 70 of about 101,193 (316)

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Gene Delivery to Chondrocytes

, 2023
AbstractDelivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different viral and non-viral vectors for this purpose.
Christopher V, Nagelli, Christopher H, Evans, Rodolfo E, De la Vega   +2 more
openaire   +2 more sources

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Mechanics of chondrocyte hypertrophy [PDF]

Biomechanics and Modeling in Mechanobiology, 2011
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
openaire   +3 more sources

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Visual histological grading system for the evaluation of in vitro-generated neocartilage [PDF]

, 2006
Here we present the development of a visual evaluation system for routine assessment of in vitro-engineered cartilaginous tissue. Neocartilage was produced by culturing human articular chondrocytes in pellet culture systems or in a scaffold-free ...
Fitzsimmons, James S., O'Driscoll, Shawn, O`Driscoll, Shawn, Grogan, Shawn Patrick, Winkelmann, Verena, Martin, Ivan, Rieser, Franz, Barbero, Andrea, Fitzsimmons, James S, Mainil-Varlet, Pierre   +9 more
core   +1 more source

Redifferentiated Chondrocytes for the Repair of Articular Cartilage Lesions

Orthopaedic Journal of Sports Medicine, 2017
Objectives: Biological therapies such as autologous chondrocyte implantation which use serially passaged chondrocytes to repair cartilage defects, are often unsuccessful as they lead to the formation of fibrocartilage.
Vanessa Juliana Bianchi B.Sc., John S. Theodoropoulos MD, FRCSC, Rita Kandel M.D., David Backstein MEd, M.D., FRCSC   +3 more
doaj   +1 more source

Mechanoelectrical transduction in chondrocytes

Clinical and Experimental Pharmacology and Physiology, 2018
SummaryCartilage tissue lines the joints of mammals, helping to lubricate joint movement and distribute mechanical loads. This tissue is comprised of isolated cells known as chondrocytes which are embedded in an extracellular matrix. Chondrocytes produce and maintain the cartilage by sensing and responding to changing mechanical loads. Mechanosensitive
Servin-Vences, MR, Richardson, J, Lewin, GR, Poole, K   +3 more
openaire   +3 more sources

Tunable 3D‐Printed Static Mixers for Gradient Bioprinting With High Cell Viability

Advanced Materials Technologies, EarlyView.
ABSTRACT The fabrication of native tissue‐like structures with gradual transitions in material properties, cell types, and growth factors remains a major challenge in biofabrication due to the lack of suitable methods. Mimicking the hierarchical organization of living tissues is essential for functional models, yet creating gradient, multimaterial ...
Florian Hofmann, Jessica Faber, Franz Moser, Alessandro Cianciosi, Nicoletta Murenu, Joachim Schenk, Katrin G. Heinze, Natascha Schaefer, Silvia Budday, Tomasz Jungst   +9 more
wiley   +1 more source

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia

, 2000
Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C, Lester, D, Thorp, B H, Botman, M, Farquharson, C; id_orcid, Thorp, B.H, Jefferies, D, Whitehead, C.C, Houston, B, Whitehead, C C   +9 more
core   +1 more source