Results 81 to 90 of about 101,193 (316)

Precultivation of engineered human nasal cartilage enhances the mechanical properties relevant for use in facial reconstructive surgery [PDF]

, 2006
To investigate if precultivation of human engineered nasal cartilage grafts of clinically relevant size would increase the suture retention strength at implantation and the tensile and bending stiffness 2 weeks after implantation.
Pierer, Gerhard, Miot, S, Martin, I, Daniels, A. U., Heberer, M, Dickinson, Sally C., Heberer, Michael, Fulco, Ilario, Haug, M, Farhadi, J, Hollander, AP, Farhadi, Jian, Miot, Sylvie, Fulco, I, Hollander, Anthony P., Wirz, Dieter, Martin, Ivan, Daniels, AU, Dickinson, SC, Haug, Martin, Wirz, D, Pierer, G   +21 more
core   +1 more source

The use of commercially available adhesive tapes to preserve cartilage and bone tissue integrity during cryosectioning

BioTechniques, 2018
The use of fluorescent tags to monitor protein expression and to lineage-trace cells has become a standard complement to standard histological techniques in the fields of embryology, pathology and regenerative medicine.
Maxwell A Serowoky, Divya D Patel, Jason W Hsieh, Francesca V Mariani   +3 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis

Genes and Diseases
Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders our understanding of the pathogenesis of osteoarthritis (OA).
Changyuan Huang, Bin Zeng, Bo Zhou, Guanming Chen, Qi Zhang, Wenhong Hou, Guozhi Xiao, Li Duan, Ni Hong, Wenfei Jin   +9 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Bi-zonal cartilaginous tissues engineered in a rotary cell culture system [PDF]

, 2006
In this study, we aimed at validating a rotary cell culture system (RCCS) bioreactor with medium recirculation and external oxygenation, for cartilage tissue engineering.
Farhadi, J., Martin, I, Jakob, M, Jakob, M., Quinn, TM, Heberer, M, Wendt, D, Sims, T. J., Farhadi, J, Quinn, T. M., Marsano, A., Wendt, D., Martin, I., Heberer, M., Marsano, A, Sims, TJ   +15 more
core  

Target-like chondrocytes with thick perichondrocytic rings in cartilage-forming tumours. Preliminary report

, 2021
Background. Here we present our experience with the occurrence of neoplastic chondrocytes with target-like appearance surrounded with unusual hypertrophic thick eosinophilic perichondrocytic rings (baskets), sometimes containing two or several layers ...
Martin Kana, Ctibor Povysil
core   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Viscoelastic Cell Mechanics and actin remodelling are dependent on the rate of applied pressure

, 2012
Background: living cells are subjected to external and internal mechanical stresses. The effects of these stresses on the deformation and subsequent biological response of the cells remains unclear. This study tested the hypothesis that the rate at which
Martin M Knight, Bader, DL, Bader, Dan L., Knight, Martin M., Knight, MM, Pravincumar, Priyanka, Priyanka Pravincumar, Dan L Bader, Pravincumar, P   +8 more
core   +1 more source