Results 91 to 100 of about 101,193 (316)
Advanced Science, EarlyView.An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan +10 more
wiley +1 more source
Advanced Science, EarlyView.(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin +12 more
wiley +1 more source
The Potential of Pulsed Low Intensity Ultrasound to stimulate Chondrocytes in a 3D Model System
, 2009 PhDPulsed low intensity ultrasound (PLIUS) is used clinically to accelerate fracture healing. although the mode of action is unclear. However studies suggest that PLIUS may stimulate endochondral ossification and consequently PLIUS may also be ...
Vaughan, Natalie Marlene
core
, 2020 Introduction Osteoarthritis (OA) is an inflammatory disorder of synovial joints which is mainly treated with therapeutic agents showing side effects associated with the gastrointestinal (GI) and metabolic system.
Gang Hong
core +1 more source
TBBPA exposure causes cartilage cell damage in both in vitro and in vivo models
Ecotoxicology and Environmental SafetyTetrabromobisphenol A (TBBPA) is a widely used flame retardant. TBBPA is a persistent pollutant that is difficult to degrade and causes sustained pollution to the environment.
Bohao Yin +3 more
doaj +1 more source
Advanced Science, EarlyView.Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu +15 more
wiley +1 more source
The effect of silymarin on chondrocytes
, 2017 Introduction: Osteoarthritis (OA) is a degenerative joint disease partially mediated by the catabolic cytokine TNF-α, leading to progressive and permanent degeneration of cartilage. Silymarin, an extract from the ripe seeds of Silybum marianum, possesses
Stephen Getting +9 more
core +1 more source
Engineering of cartilage tissue constructs in a 3-dimensional perfusion bioreactor culture system under controlled oxygen tension [PDF]
, 2007 The most relevant results generated in this thesis can be summarized as follow: · Adult human articular chondrocytes (AHAC) from elderly individuals expanded in culture medium supplemented with the growth factors TGFβ-1, FGF-2 and PDGF and ...
Ströbel, Simon
core +1 more source
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
A low percentage of autologous serum can replace bovine serum to engineer human nasal cartilage [PDF]
, 2008 For the generation of cell-based therapeutic products, it would be preferable to avoid the use of animal-derived components. Our study thus aimed at investigating the possibility to replace foetal bovine serum (FBS) with autologous serum (AS) for the ...
Farhadi, J. +11 more
core