Results 101 to 110 of about 101,193 (316)
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
Urocortin protects chondrocytes from acute trauma in articular cartilage
, 2017 Purpose: Single injurious mechanical impact to joints, as seen in sports injury, is known to be associated with a high risk of later development of osteoarthritis (OA).
Richardson, S.M. +6 more
core +1 more source
In Vitro Evaluation of Vancomycin-Induced Toxicity in Human Primary Knee Chondrocytes
, 2023 Septic arthritis as a complication of orthopaedic joint surgery can have catastrophic outcomes for patients. To minimise infection risk associated with elective orthopaedics, topical vancomycin during surgery has become increasingly common.
Grayson, J +4 more
core +1 more source
Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation [PDF]
European Cells & Materials, 2011 he cellular mechanisms by which articular cartilage responds to load are poorly understood, but such responses may involve regulation at the level of protein translation rather than synthesis of mRNA.
C Lomas +4 more
doaj
Advanced Science, EarlyView.This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng +10 more
wiley +1 more source
Morphological properties of articular chondrocytes in various experimental and clinical conditions [PDF]
, 2015 Previous work has suggested that there exists a relationship between chondrocyte morphology and matrix metabolism. Changes to chondrocyte morphology have been reported in human cartilage however it is unclear if these are involved in the degenerative ...
Karim, Asima
core
JCI InsightThe resting zone of the postnatal growth plate is organized by slow-cycling chondrocytes expressing parathyroid hormone-related protein (PTHrP), which include a subgroup of skeletal stem cells that contribute to the formation of columnar chondrocytes ...
Shion Orikasa +8 more
doaj +1 more source
Mechanisms of chondrocyte apoptosis
Osteoarthritis and Cartilage, 1999 This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Lotz, M., Hashimoto, S., Kühn, K.
openaire +2 more sources
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
, 2007 Articular cartilage is likely a major candidate to be successfully regenerated by tissue engineering methods; first commercial products have already reached the market. However, to fully regenerate articular cartilage tissue, further optimization appears
Appel, Bernhard
core +1 more source