iScience, 2021 Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata +12 more
doaj +1 more source
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
doaj +1 more source
Are ankle chondrocytes from damaged fragments a suitable cell source for cartilage repair? [PDF]
, 2010 To characterize the post-expansion cartilage-forming capacity of chondrocytes harvested from detached fragments of osteochondral lesions (OCLs) of ankle joints (Damaged Ankle Cartilage Fragments, DACF), with normal ankle cartilage (NAC) as ...
Miot, S +19 more
core +1 more source
Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]
, 2006 Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M. +9 more
core +1 more source
Intra-individual comparison of human ankle and knee chondrocytes in vitro: relevance for talar cartilage repair [PDF]
, 2009 OBJECTIVE: As compared to knee chondrocytes (KC), talar chondrocytes (TC) have superior synthetic activity and increased resistance to catabolic stimuli. We investigated whether these properties are maintained after TC are isolated and expanded in vitro.
Bonacina, E +20 more
core +1 more source
ELR+ CXC chemokine signalling in cartilage homeostasis. [PDF]
, 2011 PhDThe production of ELR+ CXC chemokines is widely studied in arthritis and has been postulated to contribute to the inflammatory phenomena that eventually lead to cartilage breakdown.
Sherwood, Joanna
core +4 more sources
The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures [PDF]
, 2010 Pulsed low intensity ultrasound (PLIUS) has been used successfully for bone fracture repair and has therefore been suggested for cartilage regeneration.
Grainger, James +11 more
core +1 more source
Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]
, 2007 The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Candrian, Christian +7 more
core +1 more source
Expressions of local renin-angiotensin system components in chondrocytes
European Journal of Histochemistry, 2014 In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line that involves differentiation from mesenchymal stem cells to ...
I. Tsukamoto +5 more
doaj +1 more source
Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]
, 2005 Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin +3 more
core +1 more source