Results 21 to 30 of about 231,673 (393)

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression

npj Regenerative Medicine, 2021
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Lee   +6 more
doaj   +1 more source

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages [PDF]

, 2010
Oxygen is a critical parameter proposed to modulate the functions of chondrocytes ex-vivo as well as in damaged joints. This article investigates the effect of low (more physiological) oxygen percentage on the biosynthetic and catabolic activity of human
Ströbel, Simon, Loparic, Marko, Wendt, David, Schenk, Andreas D., Candrian, Christian, Lindberg, Raija L. P., Moldovan, Florina, Barbero, Andrea, Martin, Ivan   +8 more
core   +2 more sources

Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes

Chinese Medical Journal, 2021
. Background. Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis (OA). However, studies that improve mitochondrial function are rare in OA. Mitochondrial transfer from mesenchymal stem
Rui Wang, Talatibaike Maimaitijuma, Yuan-Yuan Ma, Yang Jiao, Yong-Ping Cao, Qiang Shi   +5 more
doaj   +1 more source

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

Acta Pharmaceutica Sinica B, 2019
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression.
Feng Zhou, Jingtian Mei, Xiuguo Han, Hanjun Li, Shengbing Yang, Min-qi Wang, L. Chu, H. Qiao, Ting‐ting Tang   +8 more
semanticscholar   +1 more source

A review of the differences between normal and osteoarthritis articular cartilage in human knee and ankle joints [PDF]

, 2009
Background: Osteoarthritis (OA) is the most common joint disease yet its pathophysiology is still poorly understood. It is more prevalent in some lower limb joints than others; in particular the knee is more commonly affected than the ankle.
Beeson, Paul, Hendren, Linda, The University of Northampton   +2 more
core   +1 more source

Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients

Stem Cells International, 2014
Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix.
Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu   +4 more
doaj   +1 more source

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

Osteochondrosis lesions of the lateral trochlear ridge of the distal femur in four ponies [PDF]

, 2011
Lesions of the lateral trochlear ridge (LTR) of the distal femur were investigated in four pony or pony cross horses. The animals were all geldings and were six to 15 months of age.
Henson, F.M.D., Jeffcott, L.B., Platt, D., Voute, L.C.   +3 more
core   +1 more source

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

Autophagy, 2019
A switch from autophagy to apoptosis is implicated in chondrocytes during the osteoarthritis (OA) progression with currently unknown mechanism(s). In this study we utilized a flow fluid shear stress (FFSS) model in cultured chondrocytes and a unilateral ...
Hongxu Yang, Yi Wen, Mian Zhang, Qian Liu, Hongyun Zhang, Jing Zhang, Lei Lu, T. Ye, X. Bai, G. Xiao, Mei‐qing Wang   +10 more
semanticscholar   +1 more source

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Frontiers in Bioengineering and Biotechnology, 2021
Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis.
Yuzhao Huang, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Meagan J. Makarcyzk, Hang Lin, Hang Lin, Hang Lin   +7 more
doaj   +1 more source