Results 21 to 30 of about 101,193 (316)

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin, Lioté, Frédéric, Rey, Christian, Ea, Hang-Korng   +3 more
core   +1 more source

Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

Stem Cell Research & Therapy, 2017
Background Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from donors younger than 13 years of age ...
Jieun Lee, Piera Smeriglio, Constance R. Chu, Nidhi Bhutani   +3 more
doaj   +1 more source

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]

, 2012
Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Sylvie Miot, Giuseppe M. Peretti, I. Martin, Peretti, Giuseppe M., Barbero, Andrea, S. Miot, A. Barbero, Miot, Sylvie, C. Scotti, Osmokrovic, Andrea, Celeste Scotti, A. Osmokrovic, Wolf, Francine, F. Wolf, Andrea Barbero, Scotti, Celeste, Francine Wolf, Martin, Ivan, Ivan Martin, G. Peretti, Andrea Osmokrovic   +20 more
core   +1 more source

Differences in Cartilage-Forming Capacity of Expanded Human Chondrocytes from Ear and Nose and Their Gene Expression Profiles

Cell Transplantation, 2011
The aim of this study was to evaluate the potential of culture-expanded human auricular and nasoseptal chondrocytes as cell source for regeneration of stable cartilage and to analyze the differences in gene expression profile of expanded chondrocytes ...
Catharine A. Hellingman, Eugène T. P. Verwiel, Inez Slagt, Wendy Koevoet, René M. L. Poublon, Gilbert J. Nolst-Trenité, Robert J. Baatenburg De Jong, Holger Jahr, Gerjo J. V. M. Van Osch   +8 more
doaj   +1 more source

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Frontiers in Bioengineering and Biotechnology, 2021
Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis.
Yuzhao Huang, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Meagan J. Makarcyzk, Hang Lin, Hang Lin, Hang Lin   +7 more
doaj   +1 more source

Metaplasia of Chondrocytes into Osteoblasts

Folia Biologica, 2006
Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H, Włodarski, Paweł K, Włodarski, Aniela, Brodzikowska   +2 more
openaire   +2 more sources

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian, Gianni-Barrera, Roberto, Juelke, Henriette, Martin, Ivan, Jaquiery, Claude, Acharya, Chitrangada, Barbero, Andrea, Miot, Sylvie, Pelttari, Karoliina, Mainil-Varlet, Pierre   +9 more
core   +1 more source

Expressions of local renin-angiotensin system components in chondrocytes

European Journal of Histochemistry, 2014
In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line that involves differentiation from mesenchymal stem cells to ...
I. Tsukamoto, M. Akagi, S. Inoue, K. Yamagishi, S. Mori, S. Asada   +5 more
doaj   +1 more source