Results 31 to 40 of about 33,920 (248)

Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]

, 2012
Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Sylvie Miot, Giuseppe M. Peretti, I. Martin, Peretti, Giuseppe M., Barbero, Andrea, S. Miot, A. Barbero, Miot, Sylvie, C. Scotti, Osmokrovic, Andrea, Celeste Scotti, A. Osmokrovic, Wolf, Francine, F. Wolf, Andrea Barbero, Scotti, Celeste, Francine Wolf, Martin, Ivan, Ivan Martin, G. Peretti, Andrea Osmokrovic   +20 more
core   +1 more source

High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions

Osteoarthritis and Cartilage Open
Objective: Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts.
Lekha Jain, Jacob T. Munro, Jade Tamatea, Nicola Dalbeth, Raewyn C. Poulsen   +4 more
doaj   +1 more source

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian, Gianni-Barrera, Roberto, Juelke, Henriette, Martin, Ivan, Jaquiery, Claude, Acharya, Chitrangada, Barbero, Andrea, Miot, Sylvie, Pelttari, Karoliina, Mainil-Varlet, Pierre   +9 more
core   +2 more sources

Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model.

PLoS ONE, 2019
A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn, Seon Ae Kim, Ki Won Kim, Joon Hyuck Oh, Seok Jung Kim   +4 more
doaj   +1 more source

Viscoelastic response of cells and the role of actin cytoskeletal remodelling. [PDF]

, 2012
PhDThe mechanical properties of living cells provide useful information on cellular structure and function. In the present study a micropipette aspiration technique was developed to investigate the viscoelastic parameters of isolated articular ...
Pravincumar, Priyanka
core   +4 more sources

Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α , nuclear factor-κ B and reactive oxygen species

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj   +1 more source

Metaplasia of Chondrocytes into Osteoblasts

Folia Biologica, 2006
Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H, Włodarski, Paweł K, Włodarski, Aniela, Brodzikowska   +2 more
openaire   +2 more sources

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +2 more sources

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

Journal of Orthopaedic Surgery and Research, 2020
Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian, Shu-Guang Gao, Yu-Sheng Li, Chao Cheng, Zhen-Han Deng, Wei Luo, Fang-Jie Zhang   +6 more
doaj   +1 more source

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. [PDF]

PLoS Genetics, 2011
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.
Victor Y L Leung, Bo Gao, Keith K H Leung, Ian G Melhado, Sarah L Wynn, Tiffany Y K Au, Nelson W F Dung, James Y B Lau, Angel C Y Mak, Danny Chan, Kathryn S E Cheah   +10 more
doaj   +1 more source