Results 31 to 40 of about 101,193 (316)

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes [PDF]

, 2007
Objective: To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints.
A. Marsano, Jakob, M., I. Martin, E. Kon, Tognana, E., Nehrer, S., D.M. Salter, E. Tognana, Marsano, A., Adesida, A., Hardingham, T., Salter, D.M., S.J. Millward-Sadler, Salter, D. M., A. Adesida, S. Nehrer, T. Hardingham, Chiari-Grisar, C., Kon, E., Martin, I., Millward-Sadler, S. J., M. Jakob, C. Chiari-Grisar, Millward-Sadler, S.J.   +23 more
core   +1 more source

High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions

Osteoarthritis and Cartilage Open
Objective: Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts.
Lekha Jain, Jacob T. Munro, Jade Tamatea, Nicola Dalbeth, Raewyn C. Poulsen   +4 more
doaj   +1 more source

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +1 more source

Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model.

PLoS ONE, 2019
A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn, Seon Ae Kim, Ki Won Kim, Joon Hyuck Oh, Seok Jung Kim   +4 more
doaj   +1 more source

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α , nuclear factor-κ B and reactive oxygen species

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj   +1 more source

SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. [PDF]

PLoS Genetics, 2011
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.
Victor Y L Leung, Bo Gao, Keith K H Leung, Ian G Melhado, Sarah L Wynn, Tiffany Y K Au, Nelson W F Dung, James Y B Lau, Angel C Y Mak, Danny Chan, Kathryn S E Cheah   +10 more
doaj   +1 more source

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

Journal of Orthopaedic Surgery and Research, 2020
Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian, Shu-Guang Gao, Yu-Sheng Li, Chao Cheng, Zhen-Han Deng, Wei Luo, Fang-Jie Zhang   +6 more
doaj   +1 more source

Immunological Response against Allogeneic Chondrocytes Transplanted into Joint Surface Defects in Rats

Cell Transplantation, 1997
Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc, Jacek Malejczyk, Anna Osiecka, Stanislaw Moskalewski   +3 more
doaj   +1 more source

ATG5 regulates type Ⅱ collagen expression by modulation of autophagy

陆军军医大学学报, 2023
Objective To explore the regulative effect of autophagy-related protein ATG5 on the expression of type Ⅱ collagen in human chondrocytes through affecting autophagy function.
DENG Lin, XIAN Menglin, YANG Yuyou
doaj   +1 more source