CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response [PDF]
Frontiers in Pharmacology, 2022 Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li +11 more
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Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats [PDF]
Acta Pharmaceutica Sinica B, 2021 Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han +12 more
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The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases [PDF]
Frontiers in Pharmacology, 2019 The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall.
Jiajie Tu +9 more
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CP-25, a Novel Anti-inflammatory and Immunomodulatory Drug, Inhibits the Functions of Activated Human B Cells through Regulating BAFF and TNF-alpha Signaling and Comparative Efficacy with Biological Agents [PDF]
Frontiers in Pharmacology, 2017 Paeoniflorin-6′-O-benzene sulfonate (code: CP-25) was the chemistry structural modifications of Paeoniflorin (Pae). CP-25 inhibited B cells proliferation stimulated by B cell activating factor belonging to the TNF family (BAFF) or Tumor necrosis factor ...
Feng Zhang +13 more
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A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice [PDF]
Frontiers in Pharmacology, 2018 Paeoniflorin-6’-O-benzene sulfonate (CP-25) is a modified paeoniflorin, which is the main bioactive component of total glucosides of peony. This study evaluated the anti-inflammatory and immunoregulatory effects of CP-25 in mice with collagen-induced ...
Jingyu Chen +5 more
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Biochemistry and Biophysics Reports, 2021 CmPI-II is a Kazal-type tight-binding inhibitor isolated from the Caribbean snail Cenchritis muricatus. This inhibitor has an unusual specificity in the Kazal family, as it can inhibit subtilisin A (SUBTA), elastases and trypsin. An alanine in CmPI-II P1
Laritza Rojas +5 more
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A chronic low dosage of taurine induces muscle weakness in castrated-aged mice
Translational Medicine of Aging, 2021 Taurine is an abundant metabolite associated with regulation of cell volume. Several signaling pathways are stimulated at a micromolar concentrations of taurine. However, most of the experimental studies employ this compound at a very high concentration (
Noelia G. Barragán-Ceballos +8 more
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Heliyon, 2020 The Manjacazi district is composed of vast alluvial plains with aplenty clay soils in their numerous valleys. Regardless of its high proportion, clay soils from Manjacazi are only exploited for conventional pottery and local ceramic bricks.
Vicente Albino Manjate +2 more
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MORPHOMETRY OF Fasciola hepatica COLLECTED FROM LIVERS OF TWO HOSTS IN CENTRAL TABASCO, MEXICO
Tropical and Subtropical Agroecosystems, 2021 Background. Fasciolosis is a zoonotic parasitic disease, which affects different ruminant and non-ruminant hosts from tropical and temperate regions around the world. There are reports that parasites of the genus Fasciola, particularly F.
Nadia Florencia Ojeda-Robertos +7 more
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Especies de Pythium aisladas de aguas de uso agrícola en Culiacán, Sinaloa
Ecosistemas y Recursos Agropecuarios, 2022 Los Oomycetes son un grupo de organismos que alberga géneros y especies destructivas de plantas cultivadas y silvestres.EnMéxico, especialmente en el Estado Sinaloa, la información sobre esos organismos y su presencia en aguas ...
Felipe Ayala-Tafoya +3 more
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