Results 111 to 120 of about 39,155 (203)

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Persistent müllerian duct syndrome with transverse testicular ectopia: A novel anti-müllerian hormone receptor mutation

, 2017
Persistent Müllerian duct syndrome is the result of either anti-Müllerian hormone (AMH) deficiency or AMH receptor resistance. A long tubular structure was palpated during the physical examination of a 13-month-old male patient who had presented with ...
Onay H., Gökşen D., Özkınay F., Şen S., Avanoğlu A., Özen S., Özcan N., Bayındır P., Darcan Ş., Korkmaz Ö.   +9 more
core   +1 more source

Stage IIIC Bilateral Dysgerminoma in a 16‐Year‐Old Phenotypic Female With 46,XY Complete Gonadal Dysgenesis and Primary Amenorrhea: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Dysgerminoma, the most common malignant ovarian germ cell tumor, has a significantly increased incidence in individuals with 46,XY complete gonadal dysgenesis (Swyer syndrome). However, primary amenorrhea is the hallmark presentation of Swyer syndrome in adolescence.
Mahshid Vasef, Noushin Afshar Moghaddam, Masoomeh Raoufi, Maryam Iranipour, Samar Moghadami   +4 more
wiley   +1 more source

Fortuitous Persistent Müllerian Duct Syndrome Diagnosis in an Adult Patient With Hematuria: A Case Report

Clinical Case Reports
Persistent Müllerian duct syndrome is a genetic disorder. It consists of Müllerian duct remains due to improper anti‐Müllerian hormone. Early life presentation is often associated with undescended testes or inguinal hernias.
Alexi Boitsios, Tobias Schick, Romane Brawermann, Alexis Buggenhout   +3 more
doaj   +1 more source

Efficacy and safety of pulsatile GnRH pump therapy in male infants with congenital hypogonadotropic hypogonadism

Endocrine Connections
Introduction: To investigate the efficacy and safety of pulsatile gonadotropin-releasing hormone pump therapy in male infants with congenital hypogonadotropic hypogonadism.
Xi Wang, Zi Xia Zhang, Jiajia Chen, Dongxia Fu, Mengmeng Du, Yongxing Chen, Haiyan Wei   +6 more
doaj   +1 more source

Multi‐Omic Profiling of Gut Microbiota and Fecal Metabolites in Patients With Polycystic Ovary Syndrome: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim Intestinal flora composition in polycystic ovary syndrome (PCOS) varies, and the relationship between intestinal flora, fecal metabolites, clinical characteristics, and PCOS pathogenesis remains unclear. This study aimed to elucidate the gut microbiota characteristics of patients with PCOS, focusing on changes in normal ...
Yu‐Mei Li, Fang‐Fang He, Donge‐Liu, Bin‐Xu, Shuyi‐Li   +4 more
wiley   +1 more source

Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary

, 2016
International audienceAndrogens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are essential in human ovarian folliculogenesis.
Dewailly, Didier, Robin, Geoffroy, Decanter, Christine, Pigny, Pascal, Catteau-Jonard, Sophie, Peigne, Maëliss   +5 more
core   +1 more source

AMH specifically targets neuronal AMHR2 to modulate the progression of polycystic ovary syndrome

BMC Endocrine Disorders
Background Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder among women of childbearing age, characterized by elevated serum anti-Müllerian hormone (AMH) levels as a key biomarker.
Kaiming Wu, Chang Sun, Ning Din, Jinqian Guo, Jing Li, Zimeng Pan, Ying Wang, Miao Sun, Hongying Kuang   +8 more
doaj   +1 more source

Acupuncture Versus Clomiphene for Ovulation Induction in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Clinical Trial

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims There is evidence of the beneficial effects of acupuncture in the treatment of polycystic ovary syndrome (PCOS). This study aimed to compare acupuncture with clomiphene in ovulation induction among infertile women with PCOS.
Leili Hafizi, Hamideh Azizi, Malihe Mahmoudinia, Mona Jafari, Hamidreza Bahrami Taghanaki, Habibollah Esmaili, Shiva Golmohammadzadeh, Hoda Azizi   +7 more
wiley   +1 more source

Sex Determination in Sponges

Molecular Reproduction and Development, Volume 93, Issue 6, June 2026.
ABSTRACT Sex determination in Porifera remains one of the least understood aspects of early metazoan biology despite the group's key phylogenetic position. Sponges display exceptional diversity in sexual systems—ranging from stable gonochorism to sequential hermaphroditism and sex reversal—yet lack morphological dimorphism and any discrete gonadal ...
Jose M. Lorente‐Sorolla, Ana Riesgo
wiley   +1 more source