Results 191 to 200 of about 41,260 (220)

The bacterial envelope as a target for novel anti-MRSA antibiotics

Trends in Pharmacological Sciences, 2008
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA) are spreading worldwide, making the search for antibiotics directed against new targets a high priority. Drugs that anchor in the bacterial membrane (e.g. ceragenins and lipopeptides) or that target the bacterial membrane and proteic (lipoglycopeptides) or ...
Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Struelens, Marc, Tulkens, Paul M.   +3 more
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Novel dithiocarbamate carbapenems1 with anti-MRSA activity

Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin,
Norikazu Ohtake, Hideaki Imamura, Hideo Kiyonaga, Hideki Jona, Masayuki Ogawa, Shigemitsu Okada, Aya Shimizu, Minoru Moriya, Hiroki Sato, Yushin Tominaga, Koji Yamada, Masato Nakano, Ryosuke Ushijima, Susumu Nakagawa   +13 more
openaire   +1 more source

Benzothiazolylthio carbapenems: potent anti-MRSA agents

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented which delimits the pharmacophore and provides a preliminary SAR.
Sherman T. Waddell, Ronald W. Ratcliffe, Sandra P. Szumiloski, Kenneth J. Wildonger, Robert R. Wilkening, Timothy A. Blizzard, Joann Huber, Joyce Kohler, Karen Dorso, Earl St. Rose, Jon G. Sundelof, Gail G. Hammond   +11 more
openaire   +1 more source

Anti-MRSA activity of chlorophenyl pyrrolo benzodiazepines compound

The Journal of Antibiotics
Antibiotic resistant is the major concern in public health to control the infectious diseases. MRSA (Methicillin-resistant Staphylococcus aureus) is a significant concern in healthcare settings due to its resistance to many antibiotics, including methicillin and other beta-lactams.
Suresh K. Mondal, Sk Aftabul Alam, Gourisankar Roymahapatra, Santi M. Mandal   +3 more
openaire   +2 more sources

A new anti-MRSA dipeptide, TAN-1057 A

Tetrahedron, 1993
Abstract The chemical structure of a new dipeptide antibiotic, TAN-1057 A, isolated from the broth filtrate of Flexibacter sp. PK-74 was determined to be (3′S, 5S)-5-[N-methyl-N-(3′-amino-6′-guanidinohexanoyl)amino]5,6-dihydro-2-ureido-4(1H)-pyrimidone.
Yasunori Funabashi, Shigetoshi Tsubotani, Katsuo Koyama, Nozomi Katayama, Setsuo Harada   +4 more
openaire   +1 more source

In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

Journal of Infection and Chemotherapy, 2004
TAK-599 is a water-soluble prodrug of a cephalosporin compound, T-91825. In vitro and in vivo antibacterial activities of T-91825 and TAK-599, respectively, were examined. T-91825 was active against both gram-positive and gram-negative bacteria, unlike vancomycin and linezolid, which are inactive against gram-negative bacteria.
Yuji, Iizawa, Junko, Nagai, Tomoyasu, Ishikawa, Shohei, Hashiguchi, Masafumi, Nakao, Akio, Miyake, Kenji, Okonogi   +6 more
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Rationale of Antibiotics Anti-MRSA in Pneumonia

2013
Staphylococcus aureus is a bacterium causing a broad variety of infections, ranging from minor skin infections to severe pneumonia and sepsis. The genetic adaptation occurred after the introduction of meticillin into clinical practice in the 1960s [1] has led to a multidrug-resistant pathogen, meticillin-resistant S. aureus (MRSA).
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[Molecular design of anti-MRSA drugs].

Nihon rinsho. Japanese journal of clinical medicine, 1997
The true nature of resistance of methicillin-resistant Staphylococcus aureus (MRSA) is penicillin-binding protein 2' (PBP2'). Affinities of almost all beta-lactam antibiotics to PBP2' were very low. Therefore, MRSA which produces PBP2' shows resistance to all beta-lactam antibiotics.
openaire   +1 more source

[Advances in the study of anti-MRSA natural products].

Yao xue xue bao = Acta pharmaceutica Sinica, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) is a multi-drug resistant pathogenic bacteria, which has seriously threatened human health for a long time. Discovery of novel anti-MRSA lead compounds with high efficiency and low toxicity represents an important research focus in the realm of antibiotic studies.
Hao, Song, Yong, Qin
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Anti-MRSA Cephems: An Update

Current Medicinal Chemistry -Anti-Infective Agents, 2002
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