Results 1 to 10 of about 498,913 (308)

Comparative Transcriptome-Based Mining of Genes Involved in the Export of Polyether Antibiotics for Titer Improvement

Antibiotics, 2022
The anti-coccidiosis agent salinomycin is a polyether antibiotic produced by Streptomyces albus BK3-25 with a remarkable titer of 18 g/L at flask scale, suggesting a highly efficient export system.
Xian Liu, Yuanting Wu, Xiaojie Zhang, Qianjin Kang, Yusi Yan, Linquan Bai   +5 more
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Biosynthesis of ansamitocin P-3 incurs stress on the producing strain Actinosynnema pretiosum at multiple targets

Communications Biology, 2023
Microbial bioactive natural products mediate ecologically beneficial functions to the producing strains, and have been widely used in clinic and agriculture with clearly defined targets and underlying mechanisms.
Qungang Huang, Xin Zhang, Ziyue Guo, Xinnan Fu, Yilei Zhao, Qianjin Kang, Linquan Bai   +6 more
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Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus

Frontiers in Cellular and Infection Microbiology, 2023
The emergence of bactericidal antibiotic-resistant strains has increased the demand for alternative therapeutic agents, such as antivirulence agents targeting the virulence regulators of pathogens. Staphylococcus aureus exoprotein expression (sae) locus,
Rekha Arya, Rekha Arya, Truc Kim, Joo Won Youn, Taeok Bae, Kyeong Kyu Kim   +5 more
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From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology

Molecules, 2020
Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time.
Jonathan Hira, Md. Jalal Uddin, Marius M. Haugland, Christian S. Lentz   +3 more
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Metagenomic characterization of bacterial community and antibiotic resistance genes found in the mass transit system in Seoul, South Korea

Ecotoxicology and Environmental Safety, 2022
Mass transit systems, including subways and buses, are useful environments for studying the urban microbiome, as the vast majority of populations in urban areas use public transportation.
Robin B. Guevarra, Juchan Hwang, Hyunjung Lee, Hyung Jun Kim, Yunmi Lee, David Danko, Krista A. Ryon, Benjamin Grady Young, Christopher E. Mason, Soojin Jang   +9 more
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Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies

Nature Communications, 2022
Carbamoyltransferases are a class of enzymes catalyzing carbamoylation of primary and secondary metabolites. Here, the authors show the molecular structure of the ansamycin-modifying carbamoyltransferase GdmN and repurpose the enzyme for the iterative ...
Jianhua Wei, Xuan Zhang, Yucong Zhou, Xingnuo Cheng, Zhi Lin, Mancheng Tang, Jianting Zheng, Binju Wang, Qianjin Kang, Linquan Bai   +9 more
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Structural understanding of SARS-CoV-2 virus entry to host cells

Frontiers in Molecular Biosciences, 2023
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le, Shrute Kannappan, Shrute Kannappan, Truc Kim, Jung Heon Lee, Jung Heon Lee, Hye-Ra Lee, Kyeong Kyu Kim   +7 more
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Effect of Heat Treatment on the Cavitation Erosion Behavior of Nanocrystalline Surface Layer of 304 Stainless Steel

Applied Sciences, 2023
In this study, a nanocrystalline layer composed primarily of martensite phase was prepared on the surface of 304 stainless steel. Furthermore, the martensite phase content in the nanocrystalline layer was adjusted by heat treatment at 500 °C and 550 °C ...
Nengliang Huang, Ye Tian, Rui Yang, Tonghu Xiao, Hua Li, Xiuyong Chen   +5 more
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MDDI-SCL: predicting multi-type drug-drug interactions via supervised contrastive learning

Journal of Cheminformatics, 2022
The joint use of multiple drugs may cause unintended drug-drug interactions (DDIs) and result in adverse consequence to the patients. Accurate identification of DDI types can not only provide hints to avoid these accidental events, but also elaborate the
Shenggeng Lin, Weizhi Chen, Gengwang Chen, Songchi Zhou, Dong-Qing Wei, Yi Xiong   +5 more
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Daily fosfomycin versus levofloxacin for complicated urinary tract infections

mBio, 2023
Fosfomycin, approved in the United States only for cystitis, is an attractive alternative for oral treatment of outpatient complicated urinary tract infections (cUTIs) as it has antimicrobial activity against most common uropathogens.
Nadine Rouphael, Patricia Winokur, Michael C. Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G. Fowler, Scott Evans, Randolph E. Oler, Bonifride Tuyishimire, Marina Lee, Varduhi Ghazaryan, Henry F. Chambers   +13 more
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