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Antibacterial Hydrogels [PDF]

open access: yesAdvanced Science, 2018
AbstractAntibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research.
shuqiang Li, Weiguo Xu, Changwen Zhao
exaly   +3 more sources

'Evolution-Proofing' Antibacterials [PDF]

open access: yesEvolution, Medicine, and Public Health, 2014
When antibiotics first came into use, they were so effective at curbing bacterial infections that it seemed the age-old battle of man vs. microbe would soon be at an end [1]. Eighty years and dozens of drugs later, we now know better. Following each new antibiotic’s launch, reports soon accumulated that once-treatable infections were becoming ...
Ross-Gillespie Adin, Kümmerli Rolf
openaire   +3 more sources

Comparative Transcriptome-Based Mining of Genes Involved in the Export of Polyether Antibiotics for Titer Improvement

open access: yesAntibiotics, 2022
The anti-coccidiosis agent salinomycin is a polyether antibiotic produced by Streptomyces albus BK3-25 with a remarkable titer of 18 g/L at flask scale, suggesting a highly efficient export system.
Xian Liu   +5 more
doaj   +1 more source

Antibacterial Silver [PDF]

open access: yesMetal-Based Drugs, 1994
The antibacterial activity of silver has long been known and has found a variety of applications because its toxicity to human cells is considerably lower than to bacteria. The most widely documented uses are prophylactic treatment of burns and water disinfection. However, the mechanisms by which silver kills cells are not known.
Clement, Julia L., Jarrett, Penelope S.
openaire   +2 more sources

Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
The emergence of bactericidal antibiotic-resistant strains has increased the demand for alternative therapeutic agents, such as antivirulence agents targeting the virulence regulators of pathogens. Staphylococcus aureus exoprotein expression (sae) locus,
Rekha Arya   +5 more
doaj   +1 more source

Biosynthesis of ansamitocin P-3 incurs stress on the producing strain Actinosynnema pretiosum at multiple targets

open access: yesCommunications Biology, 2023
Microbial bioactive natural products mediate ecologically beneficial functions to the producing strains, and have been widely used in clinic and agriculture with clearly defined targets and underlying mechanisms.
Qungang Huang   +6 more
doaj   +1 more source

Metagenomic characterization of bacterial community and antibiotic resistance genes found in the mass transit system in Seoul, South Korea

open access: yesEcotoxicology and Environmental Safety, 2022
Mass transit systems, including subways and buses, are useful environments for studying the urban microbiome, as the vast majority of populations in urban areas use public transportation.
Robin B. Guevarra   +9 more
doaj   +1 more source

Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies

open access: yesNature Communications, 2022
Carbamoyltransferases are a class of enzymes catalyzing carbamoylation of primary and secondary metabolites. Here, the authors show the molecular structure of the ansamycin-modifying carbamoyltransferase GdmN and repurpose the enzyme for the iterative ...
Jianhua Wei   +9 more
doaj   +1 more source

Structural understanding of SARS-CoV-2 virus entry to host cells

open access: yesFrontiers in Molecular Biosciences, 2023
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le   +7 more
doaj   +1 more source

From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology

open access: yesMolecules, 2020
Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural features of bacterial cells for the first time.
Jonathan Hira   +3 more
doaj   +1 more source

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