Results 21 to 30 of about 344,708 (259)
Nature Communications, 2022 Carbamoyltransferases are a class of enzymes catalyzing carbamoylation of primary and secondary metabolites. Here, the authors show the molecular structure of the ansamycin-modifying carbamoyltransferase GdmN and repurpose the enzyme for the iterative ...
Jianhua Wei +9 more
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Structural understanding of SARS-CoV-2 virus entry to host cells
Frontiers in Molecular Biosciences, 2023 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le +7 more
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Applied Sciences, 2023 In this study, a nanocrystalline layer composed primarily of martensite phase was prepared on the surface of 304 stainless steel. Furthermore, the martensite phase content in the nanocrystalline layer was adjusted by heat treatment at 500 °C and 550 °C ...
Nengliang Huang +5 more
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MDDI-SCL: predicting multi-type drug-drug interactions via supervised contrastive learning
Journal of Cheminformatics, 2022 The joint use of multiple drugs may cause unintended drug-drug interactions (DDIs) and result in adverse consequence to the patients. Accurate identification of DDI types can not only provide hints to avoid these accidental events, but also elaborate the
Shenggeng Lin +5 more
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Daily fosfomycin versus levofloxacin for complicated urinary tract infections
mBio, 2023 Fosfomycin, approved in the United States only for cystitis, is an attractive alternative for oral treatment of outpatient complicated urinary tract infections (cUTIs) as it has antimicrobial activity against most common uropathogens.
Nadine Rouphael +13 more
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EBioMedicine, 2023 Summary: Background: Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants.
Ahmed Bargheet +6 more
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Unconventional Antibacterials and Adjuvants
Accounts of Chemical Research, 2021 The need for new classes of antibacterials is genuine in light of the dearth of clinical options for the treatment of bacterial infections. The prodigious discoveries of antibiotics during the 1940s to 1970s, a period wistfully referred to as the Golden Age of Antibiotics, have not kept up in the face of emergence of resistant bacteria in the past few ...
Mayland Chang +3 more
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'Evolution-Proofing' Antibacterials [PDF]
Evolution, Medicine, and Public Health, 2014 When antibiotics first came into use, they were so effective at curbing bacterial infections that it seemed the age-old battle of man vs. microbe would soon be at an end [1]. Eighty years and dozens of drugs later, we now know better. Following each new antibiotic’s launch, reports soon accumulated that once-treatable infections were becoming ...
Ross-Gillespie Adin, Kümmerli Rolf
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Frontiers in Microbiology, 2020 Bacteria of the genus Saccharopolyspora produce important polyketide antibiotics, including erythromycin A (Sac. erythraea) and spinosad (Sac. spinosa). We herein report the development of an industrial erythromycin-producing strain, Sac.
Jin Lü +10 more
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Frontiers in Immunology, 2023 IntroductionThe COVID-19 pandemic has posed a major burden on healthcare and economic systems across the globe for over 3 years. Even though vaccines are available, the pathogenesis is still unclear.
Jing Zhu +7 more
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