Results 221 to 230 of about 44,692 (253)

The anti-MRSA resource: a comprehensive archive of anti-MRSA peptides and essential oils

Journal of Biomolecular Structure and Dynamics
Methicillin-resistant Staphylococcus aureus (MRSA), a major cause of fatalities due to Antimicrobial Resistance (AMR), can act as an opportunistic pathogen despite being part of the normal human flora. MRSA infections, such as skin infections, pneumonia, sepsis, and surgical site infections, have risen significantly, with bloodstream infection cases ...
Rajat Kumar Mondal, Ananya Anurag Anand, Debarup Sen, Sintu Kumar Samanta   +3 more
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Ceftaroline: a Cephalosporin with Anti-MRSA Activity

Clinical Microbiology Newsletter, 2011
Abstract Ceftaroline is a cephalosporin antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria, including contemporary resistant gram-positive phenotypes, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus pneumoniae , and penicillin-resistant S. pneumoniae .
Cheung Yee, Donald Biek, Kevin Krause, Gregory Williams   +3 more
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The bacterial envelope as a target for novel anti-MRSA antibiotics

Trends in Pharmacological Sciences, 2008
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA) are spreading worldwide, making the search for antibiotics directed against new targets a high priority. Drugs that anchor in the bacterial membrane (e.g. ceragenins and lipopeptides) or that target the bacterial membrane and proteic (lipoglycopeptides) or ...
Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Struelens, Marc, Tulkens, Paul M.   +3 more
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Novel dithiocarbamate carbapenems1 with anti-MRSA activity

Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin,
Norikazu Ohtake, Hideaki Imamura, Hideo Kiyonaga, Hideki Jona, Masayuki Ogawa, Shigemitsu Okada, Aya Shimizu, Minoru Moriya, Hiroki Sato, Yushin Tominaga, Koji Yamada, Masato Nakano, Ryosuke Ushijima, Susumu Nakagawa   +13 more
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Benzothiazolylthio carbapenems: potent anti-MRSA agents

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented which delimits the pharmacophore and provides a preliminary SAR.
Sherman T. Waddell, Ronald W. Ratcliffe, Sandra P. Szumiloski, Kenneth J. Wildonger, Robert R. Wilkening, Timothy A. Blizzard, Joann Huber, Joyce Kohler, Karen Dorso, Earl St. Rose, Jon G. Sundelof, Gail G. Hammond   +11 more
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Anti-MRSA activity of chlorophenyl pyrrolo benzodiazepines compound

The Journal of Antibiotics
Antibiotic resistant is the major concern in public health to control the infectious diseases. MRSA (Methicillin-resistant Staphylococcus aureus) is a significant concern in healthcare settings due to its resistance to many antibiotics, including methicillin and other beta-lactams.
Suresh K. Mondal, Sk Aftabul Alam, Gourisankar Roymahapatra, Santi M. Mandal   +3 more
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A new anti-MRSA dipeptide, TAN-1057 A

Tetrahedron, 1993
Abstract The chemical structure of a new dipeptide antibiotic, TAN-1057 A, isolated from the broth filtrate of Flexibacter sp. PK-74 was determined to be (3′S, 5S)-5-[N-methyl-N-(3′-amino-6′-guanidinohexanoyl)amino]5,6-dihydro-2-ureido-4(1H)-pyrimidone.
Yasunori Funabashi, Shigetoshi Tsubotani, Katsuo Koyama, Nozomi Katayama, Setsuo Harada   +4 more
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In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

Journal of Infection and Chemotherapy, 2004
TAK-599 is a water-soluble prodrug of a cephalosporin compound, T-91825. In vitro and in vivo antibacterial activities of T-91825 and TAK-599, respectively, were examined. T-91825 was active against both gram-positive and gram-negative bacteria, unlike vancomycin and linezolid, which are inactive against gram-negative bacteria.
Yuji, Iizawa, Junko, Nagai, Tomoyasu, Ishikawa, Shohei, Hashiguchi, Masafumi, Nakao, Akio, Miyake, Kenji, Okonogi   +6 more
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Factors influencing neonatal therapeutic effect of anti-MRSA drugs

Int. Journal of Clinical Pharmacology and Therapeutics, 2005
Factors influencing the neonatal therapeutic effect of anti-MRSA (methicillin-resistant Staphylococcus aureus) drugs are investigated.This study took place over a two-year period from April 1998 to March 2000. We calculated the non-adjusted odds ratio for each influential factor to determine the therapeutic effect of anti-MRSA drugs.Significant factors
H, Hayashi, T, Matsuzaki, A, Saito, M, Shimizu, Y, Matsumoto   +4 more
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Rationale of Antibiotics Anti-MRSA in Pneumonia

2013
Staphylococcus aureus is a bacterium causing a broad variety of infections, ranging from minor skin infections to severe pneumonia and sepsis. The genetic adaptation occurred after the introduction of meticillin into clinical practice in the 1960s [1] has led to a multidrug-resistant pathogen, meticillin-resistant S. aureus (MRSA).
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