Results 241 to 250 of about 920,518 (281)

TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model. [PDF]

Biochem Biophys Rep
Nomura S, Kito Y, Saigo C, Takeuchi T.
europepmc   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Proteins Lamin A and SUN1 are exclusively decreased in nuclear grade 4 clear cell renal cell carcinoma. [PDF]

Oncol Lett
Shibanuma R, Kobayashi S, Konno M, Kaneko R, Nishijima Y, Ikota H, Nomura M, Suzuki K, Yokoo H, Saio M.   +9 more
europepmc   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

A decoy oligodeoxynucleotide favors the differentiation of CpG ODN-induced B cells into IL-10-producing Breg-like cells over plasma cells by restoring IRF4/IRF8 imbalance. [PDF]

Cell Mol Life Sci
Lu F, Wang S, Zhu M, Qu K, Zhu T, Wang H, Yu Y, Wang L.   +7 more
europepmc   +1 more source

A selective RPL15 PROTAC degrader enhances anti-PD-1 immunotherapy in a murine melanoma tumor model. [PDF]

Oncogene
Takahashi R, Yamamoto K, Toya H, Shoji H, Kawanishi K, Momosaki K, Yabe M, Takashima K, Muromoto R, Ichikawa S, Matsuda T, Kitai Y.   +11 more
europepmc   +1 more source

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles. [PDF]

Elife
Tomasini C, Cuche C, Ay S, Collard M, Cui B, Rashid M, Bhattacharjee S, Tello-Rubio B, Buchrieser J, Luchsinger C, Bertelli C, Uversky V, Diaz-Griffero F, Di Nunzio F.   +13 more
europepmc   +1 more source

Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions. [PDF]

Nat Commun
Moriizumi H, Nakamura T, Kubota Y, Hiranuma R, Cho Y, Kawanishi T, Takeda H, Suzuki T, Takekawa M.   +8 more
europepmc   +1 more source