Results 131 to 140 of about 219,576 (296)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity

Diabetes, Metabolic Syndrome and Obesity, 2014
Amit A Joharapurkar, Nirav A Dhanesha, Mukul R Jain Department of Pharmacology and Toxicology, Zydus Research Centre, Cadila Healthcare Limited, Ahmedabad, India Abstract: Worldwide prevalence of obesity has nearly doubled since 1980.
Joharapurkar AA, Dhanesha NA, Jain MR
doaj  

Adipose tissue derived factors in obesity, inflammation & energy homeostasis [PDF]

Obesity is the foremost contributory factor in the progression to type 2 diabetes mellitus (T2DM). Moreover, chronic inflammation, through activation of innate immunity is proposed to link obesity, insulin resistance and T2DM.
Kusminski, C. M.
core  

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Pharmacological Weight Loss Induction

, 2022
Obesity is a common and preventable disease characterized by an excessive amount of body fat and associated with multiple pathophysiological mechanisms. Global prevalence of obesity has nearly tripled since 1975 and it affects over a third of the world’s
Iida, Haruka
core  

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Effect of green tea catechins on body weight of Albino Wistar rats—An interventional study

National Journal of Physiology, Pharmacy and Pharmacology
Background: Obesity is a serious medical condition linked to metabolic syndrome, which puts individuals with obesity at risk for developing chronic diseases.
Shilpa A. V., Ambili Gopi Nair, Biju Bahuleyan   +2 more
doaj   +1 more source

Towards mobile collaborative exergaming

, 2009
Paper presented at the 2nd International Conference on Advances in Human-oriented and Personalized Mechanisms, Technologies, and Services (CENTRIC2009), September 20-25, 2009, Porto, PortugalToday’s high calorie diets and low physical activity levels ...
Gorgu, Levent, Gregory M. P. O'Hare, O'Hare, G. M. P. (Greg M. P.), O'Grady, Michael J., Levent Gorgu, O\u27Grady, Michael J., O\u27Hare, G. M. P. (Greg M. P.), Michael J. O'Grady   +7 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

A Review: Natural Anti-Obesity Agents

Benzimidazole, a bicyclic compound formed by the fusion of benzene and imidazole rings, is recognized for its profound biological activity and significant impact on medicinal chemistry. This review provides a comprehensive analysis of benzimidazole derivatives, highlighting their key pharmacological activities, including analgesic, anti-inflammatory ...
openaire   +1 more source