Results 71 to 80 of about 219,576 (296)
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
ELECTROCHEMICAL CHARACTERIZATION OF TWO OLEAMIDE ANALOGUES ANTI-OBESITY AGENTS
Studia Universitatis Babes-Bolyai Chemia, 2015 Electrochemical characterization of two oleamide analogues was performed by cyclic voltammetry, differential pulse voltammetry, and rotating disk electrode voltammetry.
Cătălina Elena NEGUŢ (CIOATEŞ) +4 more
doaj
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Journal of Obesity & Metabolic SyndromeThe Korean Society for the Study of Obesity has published the 9th edition of its Clinical Practice Guidelines to provide updated, evidence-based recommendations for the management of overweight and obesity.
Jae Hyun Bae +7 more
doaj +1 more source
Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea
Advanced Science, EarlyView.Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li +22 more
wiley +1 more source
International Journal of Adolescent Medicine and HealthFollowing prospective registration (PROSPERO CRD42024564275), three databases (PubMed, SCOPUS, Web of Science) were searched for trials reporting the effects of anti-obesity drugs (AODs) (with placebo as control) on cardiometabolic risk factors in the ...
Aamir Ahmad Bin +5 more
doaj +1 more source
Toxicology Reports, 2019 This study confirms the anti-obesity effect of the ethyl acetate fraction of Distylium racemosum (DRE), a member of Hamamelidaceae, that naturally grows on Jeju Island, on adipocyte differentiation in 3T3-L1 cells.
Hye-Ran Kim +4 more
doaj +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Anti-Obesity Pharmacotherapy: Closing the Access Gap Through Local Manufacturing [PDF]
Journal of Advanced Biomedical SciencesThe global obesity epidemic, affecting approximately 890 million adults, has catalyzed substantial advances in pharmacological management. Contemporary anti-obesity medications, including GLP-1 receptor agonists, dual GLP-1/GIP agonists, lipase ...
Mojtaba Farjam +2 more
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