Results 61 to 70 of about 4,309,747 (310)

The pharmacological management of obesity

South African Family Practice, 2016
Obesity is a growing phenomenon and a global concern. It is well-known that it plays a significant role in the development of several preventable diseases.
André Marais
doaj   +1 more source

Dietary Modulation, Obesity And Cancer Prevention

, 2017
Cancer is the leading cause of morbidity and mortality worldwide, and the number of new cases is expected to rise. Among all the risk factors for cancers, lifestyle, eating habit and obesity are considered the most significant determining factors.
Wan, JMF, Kwan, HY
core   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Characterization of taurine as anti-obesity agent in C. elegans [PDF]

Journal of Biomedical Science, 2010
Taurine plays an important role in reducing physiological stress. Recent studies indicated that taurine may serve as an anti-obesity agent at the cellular level. This study characterizes taurine's potential anti-obesity function in C. elegans, which have become a popular in vivo model for understanding the regulatory basis of lipid biosynthesis and ...
Kim, Hye, Do, Chang-Hee, Lee, Dong
openaire   +2 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Cardiovascular Risks and Benefits of Medications Used for Weight Loss

Frontiers in Endocrinology, 2020
Obesity is a complex disease influenced by many neurohormonal pathways which regulate body weight toward homeostasis. Presently, the disease of obesity effects over a billion individuals worldwide with scalable treatment options in dire need ...
Carolyn T. Bramante, Carolyn T. Bramante, Sarah Raatz, Eric M. Bomberg, Eric M. Bomberg, Megan M. Oberle, Megan M. Oberle, Justin R. Ryder, Justin R. Ryder   +8 more
doaj   +1 more source

Influence of orlistat therapy on serum insulin level and morphological and functional parameters of peripheral arterial circulation in obese patients [PDF]

Vojnosanitetski Pregled, 2005
Background/Aim. Insulin resistance is related to accelerated atherosclerosis, whereas weight loss is associated with the increasing insulin sensitivity, the improvement of functional and the morphological parameters of arterial circulation, and the ...
Hajduković Zoran, Jovelić Aleksandra, Životić-Vanović Mirjana, Rađen Slavica   +3 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Therapeutic Potential of melatonin as an anti-obesity agent Melatonin as an anti-obesity agent

Eastern Journal of Medical Sciences
Obesity is a major healthcare crisis, with the number rising each year, which is concerning. Obesity is associated with many metabolic syndromes, heightening the risk of Type 2 diabetes mellitus, cardiovascular diseases, stroke, fatty liver, and hypertension. This imposes a substantial burden on healthcare systems, with escalating annual costs. Current
Mayank Dhalani, Abhinav Malik, Simran Dahiya, Kanishk Aggarwal, Rohit Jain   +4 more
openaire   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source