Results 41 to 50 of about 126,339 (259)
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Characterization of taurine as anti-obesity agent in C. elegans [PDF]
Journal of Biomedical Science, 2010 Taurine plays an important role in reducing physiological stress. Recent studies indicated that taurine may serve as an anti-obesity agent at the cellular level. This study characterizes taurine's potential anti-obesity function in C. elegans, which have become a popular in vivo model for understanding the regulatory basis of lipid biosynthesis and ...
Kim, Hye, Do, Chang-Hee, Lee, Dong
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Advanced Science, EarlyView.Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu +8 more
wiley +1 more source
The pharmacological management of obesity
South African Family Practice, 2016 Obesity is a growing phenomenon and a global concern. It is well-known that it plays a significant role in the development of several preventable diseases.
André Marais
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Cardiovascular Risks and Benefits of Medications Used for Weight Loss
Frontiers in Endocrinology, 2020 Obesity is a complex disease influenced by many neurohormonal pathways which regulate body weight toward homeostasis. Presently, the disease of obesity effects over a billion individuals worldwide with scalable treatment options in dire need ...
Carolyn T. Bramante +8 more
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Influence of orlistat therapy on serum insulin level and morphological and functional parameters of peripheral arterial circulation in obese patients [PDF]
Vojnosanitetski Pregled, 2005 Background/Aim. Insulin resistance is related to accelerated atherosclerosis, whereas weight loss is associated with the increasing insulin sensitivity, the improvement of functional and the morphological parameters of arterial circulation, and the ...
Hajduković Zoran +3 more
doaj +1 more source
Advanced Science, EarlyView.Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou +16 more
wiley +1 more source
Therapeutic Potential of melatonin as an anti-obesity agent Melatonin as an anti-obesity agent
Eastern Journal of Medical SciencesObesity is a major healthcare crisis, with the number rising each year, which is concerning. Obesity is associated with many metabolic syndromes, heightening the risk of Type 2 diabetes mellitus, cardiovascular diseases, stroke, fatty liver, and hypertension. This imposes a substantial burden on healthcare systems, with escalating annual costs. Current
Mayank Dhalani +4 more
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ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
Advanced Science, EarlyView.S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang +12 more
wiley +1 more source