Results 31 to 40 of about 4,309,747 (310)

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Kessler, L., Muller, Sylviane, Lecourt, Anne-Catherine, Bekel, Akkiz, Bekel, A., Zipfel, G., Peter, J. C., Kessler, Laurence, Eftekhari, Pierre, Eftekhari, P., Zipfel, Géraldine, Hofbauer, Karl G, Breidert, M., Breidert, Matthias, Lecourt, A. C., Muller, S., Nesslinger, Maya, Hofbauer, K. G., Nesslinger, M., Peter, Jean-Christophe   +19 more
core   +1 more source

Effectiveness, tolerability and practical application of the newer generation anti-obesity medications [PDF]

, 2016
Objective: Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion–naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine–topiramate combination ...
Thomas L Schwartz, Jeffrey S MacDaniels
core   +1 more source

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents. [PDF]

PLoS ONE, 2015
Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and characterize a novel diet-induced obesity (DIO) and ...
Louise S Dalbøge, Philip J Pedersen, Gitte Hansen, Katrine Fabricius, Henrik B Hansen, Jacob Jelsing, Niels Vrang   +6 more
doaj   +1 more source

Inquiry on a Potential Anti-Obesity Agent

The American Biology Teacher, 2023
This study introduces a practical work activity that allows students to investigate the inhibitory effects of seed extracts on pancreatic lipase activity. The activity is related to the issue of the ongoing global obesity epidemic and involves the use of materials and chemicals readily available in high school laboratories. We show how the activity can
Pat Chun Chan, Kennedy Kam Ho Chan
openaire   +1 more source

Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Chinese Medicine, 2011
This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia ...
Wang Guei-Jane, Shen Yuh-Chiang, Chiou Wen-Fei, Liao Jyh-Fei, Chen Chieh-Fu   +4 more
doaj   +1 more source

Flavanols are potential anti-obesity agents, a systematic review and meta-analysis of controlled clinical trials.

NMCD. Nutrition Metabolism and Cardiovascular Diseases, 2018
BACKGROUND The anti-obesity potential of flavonoids has been shown by animal and human studies. In this meta-analysis, we systematically reviewed controlled clinical trials and quantified the effects of flavonoids and flavonoid subclasses on obesity ...
M. Akhlaghi, S. Ghobadi, M. Hosseini, Z. Gholami, F. Mohammadian   +4 more
semanticscholar   +1 more source

Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses

Frontiers in Medicine, 2021
Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on
Esperanza M. Garcia-Oropesa, Yoscelina E. Martinez-Lopez, Sonia María Ruiz-Cejudo, Sonia María Ruiz-Cejudo, José Darío Martínez-Ezquerro, José Darío Martínez-Ezquerro, Alvaro Diaz-Badillo, Alvaro Diaz-Badillo, Carlos Ramirez-Pfeiffer, Alejandra Bustamante-Fuentes, Elena B. Lopez-Sosa, Oscar O. Moctezuma-Chavez, Edna J. Nava-Gonzalez, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Marisol Rosas-Diaz, Kathleen Carter, Beatriz Tapia, Juan C. Lopez-Alvarenga, Juan C. Lopez-Alvarenga   +19 more
doaj   +1 more source

Current and upcoming methods of pharmacotherapy of obesity

Journal of Education, Health and Sport, 2023
Introduction and purpose: Obesity remains an urgent problem, both worldwide and in Poland. Approximately 25% of people in Poland are obese. Therefore, anti-obesity drugs are gaining clinical importance.
Jan Bieniasz, Konrad Dendys, Marcel Kazzi, Michał Puła, Marta Wychota   +4 more
doaj   +1 more source

Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

Nature Communications, 2022
Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activity ...
Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil   +20 more
doaj   +1 more source

Clinical effectiveness and predictors of response to topiramate plus lifestyle modification in youth with obesity seen in a weight management clinical setting

Frontiers in Endocrinology
IntroductionObesity affects approximately 20% of U.S. youth. Anti-obesity medications (AOMs) are promising lifestyle modification adjuncts for obesity treatment, and topiramate is commonly prescribed in pediatric weight management clinics.
Eric M. Bomberg, Eric M. Bomberg, Justin Clark, Kyle D. Rudser, Kyle D. Rudser, Amy C. Gross, Aaron S. Kelly, Claudia K. Fox   +7 more
doaj   +1 more source