Results 31 to 40 of about 219,576 (296)

Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

Frontiers in Pharmacology, 2023
Background: The nuclear receptor Nur77 has been demonstrated to play a vital role in the inflammatory response and cellular metabolisms, and its ligands exhibit efficacy in the treatment of inflammation-related diseases (e.g., improving mouse acute lung ...
Hua Fang, Yin Cao, Jianyu Zhang, Xiumei Wang, Mengyu Li, Mengyu Li, Zhuan Hong, Zhen Wu, Meijuan Fang   +8 more
doaj   +1 more source

SAFETY OF ANTI-OBESITY AGENTS IN ADULTS NARRATIVE REVIEW

International Journal of Advanced Research, 2023
Background: Weight management medications are appropriate treatment options for individuals who are overweight or obese and have been unable to achieve weight loss with lifestyle intervention alone. In this narrative review, we aimed to review the adverse effects and safety profile of anti-obesity agents in overweight and obese patients.
Intithar Hussain Al-Herz, Sami Abdo Al-Dubai   +1 more
openaire   +3 more sources

Design, Synthesis and Biological Evaluation of a Novel Series of Thiadiazole-Based Anticancer Agents as Potent Angiogenesis Inhibitors

, 2021
Background: Thiadiazole has attracted a great deal of interest as a versatile heterocycle for the discovery and development of potent anticancer agents. Thiadiazole derivatives exert potent antitumor activity against a variety of human cancer cell lines ...
Turan, Gulhan, Gülhan Turan, KAPLANCIKLI, ZAFER ASIM, ALTUĞ, BURCUGÜL, Ali S. Koparal, KOPARAL, ALİ SAVAŞ, Ayşe T. Koparal, Burcugül Altuğ-Tasa, Betül Kaya-Çavuşoğlu, Zafer A. Kaplancıklı, Kaya-cavusoglu, Betul   +10 more
core   +1 more source

Recent Advances in Anti-Obesity Agents

The Korean Journal of Medicine, 2018
Obesity is a chronic disorder that is a significant risk factor for diabetes, cardiovascular diseases, malignancy, and other chronic diseases. Lifestyle modifications form the basis of most treatments for obesity, but it has become clear that such modifications alone are not enough for many obese patients.
Min Kyung Kim, Chul Sik Kim
openaire   +1 more source

Characterization of Tunicamycin as Anti-obesity Agent

Biomolecules and Therapeutics, 2009
Abstract － Adipocytes undergo adipocyte stress in the excessive presence of lipid. Adipocyte stress accompanies the typical signs of endoplasmic reticulum (ER) stress: unfolded protein response and overexpression of molecular chaperones. Apoptotic induction in adipocytes is known as a good strategy for treating obesity.
Ha-Suk Song, Hye-Min Kim, Sook-Yung Jung, Dong-Hee Lee   +3 more
openaire   +1 more source

Peripheral Anti-nociceptive and Anti-inflammatory Effect of OleanoliAcid in a Rat Model of Osteoarthritis [PDF]

, 2021
Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechanisms of such effects have not yet
Fouani, Malak, Fakhoury, Marc, Salman, Israa, Lawand, Nada Bashir   +3 more
core   +1 more source

Clinical effectiveness and predictors of response to topiramate plus lifestyle modification in youth with obesity seen in a weight management clinical setting

Frontiers in Endocrinology
IntroductionObesity affects approximately 20% of U.S. youth. Anti-obesity medications (AOMs) are promising lifestyle modification adjuncts for obesity treatment, and topiramate is commonly prescribed in pediatric weight management clinics.
Eric M. Bomberg, Eric M. Bomberg, Justin Clark, Kyle D. Rudser, Kyle D. Rudser, Amy C. Gross, Aaron S. Kelly, Claudia K. Fox   +7 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Therapeutic Potential of melatonin as an anti-obesity agent Melatonin as an anti-obesity agent

Eastern Journal of Medical Sciences
Obesity is a major healthcare crisis, with the number rising each year, which is concerning. Obesity is associated with many metabolic syndromes, heightening the risk of Type 2 diabetes mellitus, cardiovascular diseases, stroke, fatty liver, and hypertension. This imposes a substantial burden on healthcare systems, with escalating annual costs. Current
Mayank Dhalani, Abhinav Malik, Simran Dahiya, Kanishk Aggarwal, Rohit Jain   +4 more
openaire   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source