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Immuno-metabolic depression: challenges ahead for identification and intervention. [PDF]
World PsychiatryPenninx BWJH.
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Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: results of three complementary research designs. [PDF]
Am J EpidemiolVo TT +8 more
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The context-dependent roles of PPAR-γ in adipocyte differentiation and obesity: a master regulator with dual functions. [PDF]
Front NutrHou X, Chen Y, Dong W, Li X, Ji S.
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Economic Impact of Timely Systemic Treatment of Psoriatic Disease in Comorbidity Risk Reduction: Literature Review and (Early) Economic Assessment. [PDF]
Dermatol Ther (Heidelb)Norton N +5 more
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New hope for anti-obesity drugs
Nature Reviews Drug Discovery, 2021Could the FDA’s supplemental approval of Novo Nordisk’s semaglutide for weight loss be a turning point for anti-obesity drugs? Could the FDA’s supplemental approval of Novo Nordisk’s semaglutide for weight loss be a turning point for anti-obesity drugs?
Mullard Asher
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Current Opinion in Lipidology, 2015
The prevalence of obesity across the world continues to climb, bringing with it otherwise preventable obesity-related comorbidities including type 2 diabetes, hypertension and cardiovascular disease. Weight loss is difficult to achieve and maintain through lifestyle interventions alone, leading to intense efforts to develop adjunctive pharmacological ...
Rankin, W., Wittert, G.
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The prevalence of obesity across the world continues to climb, bringing with it otherwise preventable obesity-related comorbidities including type 2 diabetes, hypertension and cardiovascular disease. Weight loss is difficult to achieve and maintain through lifestyle interventions alone, leading to intense efforts to develop adjunctive pharmacological ...
Rankin, W., Wittert, G.
openaire +3 more sources
Expert Opinion on Pharmacotherapy, 2008
Recent discoveries about the metabolic and genetic control systems that govern regulation of body weight and energy expenditure have afforded the opportunity to develop pharmacological agents that can be used as adjunctive treatments for patients with obesity. However, the scarcity of medications available or those that have made it to Phase III trials
openaire +3 more sources
Recent discoveries about the metabolic and genetic control systems that govern regulation of body weight and energy expenditure have afforded the opportunity to develop pharmacological agents that can be used as adjunctive treatments for patients with obesity. However, the scarcity of medications available or those that have made it to Phase III trials
openaire +3 more sources
Expert Opinion on Investigational Drugs, 2002
Obesity accelerates morbidity and mortality and has been described by the World Health Organization (WHO) as an epidemic in many industrialised nations [101,102]. Diet, exercise and lifestyle recommendations have proven to be mostly ineffective in adequately preventing or treating the progression of this public health disease.
Harold, Bays, Carlos, Dujovne
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Obesity accelerates morbidity and mortality and has been described by the World Health Organization (WHO) as an epidemic in many industrialised nations [101,102]. Diet, exercise and lifestyle recommendations have proven to be mostly ineffective in adequately preventing or treating the progression of this public health disease.
Harold, Bays, Carlos, Dujovne
openaire +2 more sources
Expert Opinion on Investigational Drugs, 2000
There is increasing evidence that body weight is homeostatically regulated and that in obesity this regulation maintains weight at a high level. Weight loss activates mechanisms that are designed to return individuals to their pre-existing weight. This explains the universally poor results of current strategies to maintain weight loss.
J, Proietto +3 more
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There is increasing evidence that body weight is homeostatically regulated and that in obesity this regulation maintains weight at a high level. Weight loss activates mechanisms that are designed to return individuals to their pre-existing weight. This explains the universally poor results of current strategies to maintain weight loss.
J, Proietto +3 more
openaire +2 more sources