Results 21 to 30 of about 16,934 (261)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The uncivilized society of Czechoslovak tramps. An exploration in proletarian fantasy [PDF]

Studia Ethnologica Pragensia, 2017
This article examines the relationship between the political theories of Central European dissidents and the social practice of “tramping,” a back-to-nature movement that was associated with oppositional politics and “anti-politics” in Czechoslovakia ...
Joseph Grim Feinberg
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Review of Plantation Politics and Campus Rebellion: Power, Diversity, and the Emancipatory Struggle in Higher Education

The Professional Educator, 2022
Plantation Politics and Campus Rebellions: Power, Diversity, and the Emancipatory Struggle in Higher Education brings together a collection of inquiries that foreground the framework of “plantation politics” to highlight the pervasive nature of anti ...
Zachary R. Brown
doaj   +1 more source

Staging Uncivility, Or, The Performative Politics of Radical Decolonial Iconoclasm

Krisis, 2022
In this article I reflect on the deployment of crass vandalism in contemporary decolonial and anti-racist struggles, as exemplified by the recent activist campaign against Belgium’s colonialist patrimony.
Matthias Pauwels
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Anti-Politics as a Quasi-Regulative Idea

Politeja
The notion of anti-politics resists a straight-forward definition due to the complexity and heterogeneity of the phenomena it encompasses. Discussions of anti-politics rarely aim to identify its essence directly; rather, they describe individual ...
Dariusz Juruś
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Uncovering anti-politics by counting hyperbole: level, orientation, and ideology of rhetorical exaggeration

Frontiers in Political Science
It is often said that political rhetoric is characterized by a high degree of exaggeration. What is known as hyperbole has most often been approached from a linguistic and literary angle; research methods and empirical studies on political hyperbole are ...
Lieuwe Kalkhoven, Christ'l De Landtsheer
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source