Results 121 to 130 of about 12,098 (310)
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
From Nescience to Science: Buddhist Reflections on Human/Nature
ReligionsA Buddhist system of two truths provides a descriptive framework with criteria for what counts as real in contrast to what does not. This paper looks at the relationship between these two truths in the works of two seventh-century Indian philosophers ...
Douglas S. Duckworth
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
From meaning to morality in Kovesi and Harrison [PDF]
, 2014 The chapter shows that Bernard Harrison and Julius Kovesi are complementary thinkers, interested in similar questions, and arriving at closely comparable answers.
Tapper, Alan
core
Hacking Stereoscopic Vision: the Nineteenth-Century Culture of Critical Inquiry in Stereoscope Use
International Journal of Film and Media Arts, 2016 While recent scholarship has emphasised the narratives of immersive realism that surrounded the parlour stereoscope, my aim in this paper is to better understand the counter-currents of nineteenth century stereoscopic culture – the artefacts, practices ...
Rod Bantjes
doaj
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
, 2014 I discuss three connections between Dummett's writings about time and philosophical aspects of physics. The first connection (Section 2) arises from remarks of Dummett's about the different relations of observation to time and to space.
Butterfield, Jeremy
core
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
, 2000 I ask whether, and how far, it is possible legitimately to acquire the belief that a given item is beautiful on the basis of someone's testimony that it is. This is an issue that concerned Kant. Kant held that testimony could never be a legitimate source
Hopkins, Robert
core
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source