Results 81 to 90 of about 12,098 (310)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Relations Without Polyadic Properties: Albert the Great On the Nature and Ontological Status of Relations [PDF]
, 2001 I think it would be fair to say that, until about 1900, philosophers were generally reluctant to admit the existence of what are nowadays called polyadic properties.1 It is important to recognize, however, that this reluctance on the part of pre ...
Brower, Jeffrey E.
core +1 more source
Realismo Científico Empirista?
Principia: An International Journal of Epistemology, 1997 In his influential criticism of scientific realism, Bas van Fraassen assumes that this doctrine is incompatible with empiricism, according to which the sole ultimate basis of knowledge is experience.
Sílvio Seno Chibeni
doaj
"Putnamizacja absolutnie wszystkiego" i jej epistemologiczne reperkusje („Putnamisation of Absolutely Everything” and its Epistemological Repercussions) [PDF]
Analiza i Egzystencja, 2009 In the article inspired by Putnam’s thesis of „skolemisation of absolutely everything” (which is so called theory-modelling argument about semantic anti-realism) I try to describe Hilary Putnam’s style of philosophy, especially his argumentation in ...
Józef Dębowski
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, 2009 Abstract The basic question of ontology is ‘What exists?’ The basic question of metaontology is: are there objective answers to the basic question of ontology? Here ontological realists say yes, and ontological anti-realists say no.
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Presentism and Temporal Experience [PDF]
, 2017 - Presentism And Temporal Experience Intuitively, we all believe that we experience change and the passage of time. Presentism prides itself as the most intuitive theory of time.
Frischhut, Akiko
core
‘A realist theory of art history’. Review of: Ian Verstegen, A Realist Theory of Art History (Ontological Explorations), London and New York: Routledge 2013 [PDF]
Journal of Art Historiography, 2013 Until recently, art history has been dominated by anti-realist and social-constructivist ideologies—arguably, in a more radical form than this has been the case in other fields of the humanities. Ian Verstegen’s book A Realist theory of Art History is an
Branko Mitrović
doaj
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source