Results 81 to 90 of about 2,257,590 (283)
Christine Baron e Manfed Engel (Eds.), Realism/Anti-Realism in 20th Century Literature
Between, 2012 Parte della serie «Internationale Forschungen zur Allgemeinen und Vergleichenden Literaturwissenschaft» edita da Rodopi, il volume è composto da quattordici saggi, cinque dei quali in francese, i restanti in inglese. Come chiarisce sin dalle prime righe
Gianluigi Rossini
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Er(r)go, 2001 Grzegorz Trela – Towards anti-antirealism Artykuł poświęcony kontrowersji dzielącej metdologów nauki w kontekście sporu "realizm-antyrealizm".
Grzegorz Trela
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Is Heidegger’s “Turn” a Realist Project? [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014 In this essay I consider the relationship between Heidegger’s famous “turn” (Kehre) and realism. I begin with Heidegger’s critique of the problem of an external world, and I describe how this critique anticipates New Realism.
Markus Gabriel
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Experimental Realism Defended: How Inference to the Most Likely Cause Might Be Sound [PDF]
, 2005 On a purely epistemic understanding of experimental realism, manipulation affords a particularly robust kind of causal warrant, which is – like any other warrant – defeasible.
Suárez, Mauricio, Mauricio Suárez
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Realismo Científico Empirista?
Principia: An International Journal of Epistemology, 1997 In his influential criticism of scientific realism, Bas van Fraassen assumes that this doctrine is incompatible with empiricism, according to which the sole ultimate basis of knowledge is experience.
Sílvio Seno Chibeni
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USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source