Results 81 to 90 of about 2,078,454 (291)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Er(r)go, 2001 Grzegorz Trela – Towards anti-antirealism Artykuł poświęcony kontrowersji dzielącej metdologów nauki w kontekście sporu "realizm-antyrealizm".
Grzegorz Trela
doaj
‘A realist theory of art history’. Review of: Ian Verstegen, A Realist Theory of Art History (Ontological Explorations), London and New York: Routledge 2013 [PDF]
Journal of Art Historiography, 2013 Until recently, art history has been dominated by anti-realist and social-constructivist ideologies—arguably, in a more radical form than this has been the case in other fields of the humanities. Ian Verstegen’s book A Realist theory of Art History is an
Branko Mitrović
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Auslegung: a Journal of Philosophy, 1982 Philosophy in the twentieth century has been characterized by its attempt to give an account of the meaning of both words and sentences of language. The goal of such effort is to render philosophical questions and their proposed answers as clear and precise as possible. In this way it is believed that many philosophical difficulties may be resolved. It
openaire +2 more sources
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Realismo Científico Empirista?
Principia: An International Journal of Epistemology, 1997 In his influential criticism of scientific realism, Bas van Fraassen assumes that this doctrine is incompatible with empiricism, according to which the sole ultimate basis of knowledge is experience.
Sílvio Seno Chibeni
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Ontic structural realism and the interpretation of quantum mechanics [PDF]
, 2012 This paper argues that ontic structural realism (OSR) faces a dilemma: either it remains on the general level of realism with respect to the structure of a given theory, but then it is, like epistemic structural realism, only a partial realism; or it is ...
Esfeld, Michael
core +1 more source