Results 41 to 50 of about 1,262 (267)

Numerical Simulation of the Forming and Failure Process of Soil Arching Between Anti-slide Piles

, 2011
The mechanism of soil arching effect is important for anti-slide pile design. With the 2D particle flow method (PFC2D), the forming and failure process of the soil arching between anti-slide piles are simulated.
Ming Chen, Jin Shan Sun, Qing Hui Jiang
core   +1 more source

Effect of Soil Creep on the Bearing Characteristics of Soil Slope Reinforced with CFRP and Anti-Slide Piles

, 2023
In order to research the displacement characteristics and stability of a soil slope reinforced with carbon-fiber-reinforced plastic (CFRP) and anti-slide piles, the displacement composition, aging deformation and failure mode of a soil mass were analyzed.
Jun Wang, Lin Liu, Ping Cao
core   +1 more source

Application of Anti-slide Piles in Embankment Reconstruction Work on Soft Soil Foundation

Renmin Zhujiang, 2021
In order to study the influence of anti-slide pile layout on the anti-slide stability of the embankment reconstruction work on soft soil foundation,taking the Xindian section of Fenghua River embankment in Ningbo as the research object,this paper ...
YU Minlin
doaj  

Supporting effect analysis of the Huangnibian landslide based on MatDEM

地质科技通报, 2023
Objective The Huangnibian landslide is a small- to medium-sized cohesive soil landslide that has shown signs of movement. It is urgent to implement support and remediation measures for this landslide. This study aims at analysing the failure mechanism of
Fei Wang, Chu Xu, Wei Li
doaj   +1 more source

Stress Analysis of Double Row Anti-slide Pile [PDF]

Proceedings of the 2016 3rd International Conference on Materials Engineering, Manufacturing Technology and Control, 2016
Double row pile as a retaining structure in slope reinforcement and foundation pit support engineering and many other neighborhoods, it has a wide application. But due to the complexity and difference of the soil around the pile, the interaction mechanism between pile and soil is not clear. Calculated with different models and assumptions of double row
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Landslide–Tunnel Interactions and Control Countermeasures under an Orthogonal System

Applied Sciences
When a tunnel crosses a landslide orthogonally, this interaction can easily lead to instability in both the landslide and tunnel structures. Based on the relative positional relationship between a landslide and a tunnel, we studied the stress mode and ...
Yang Chen, Pengfei Li, Shuai Lu, Zhijie Sun, Shizhao Zhu   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source