Results 51 to 60 of about 1,262 (267)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Water mill drilling technology for landslide emergency treatment of oil and gas pipelines and its application

You-qi chuyun, 2021
By summarizing and analyzing the types and characteristics of the landslide hazards to the oil and gas pipelines, the emergency treatment methods were developed, the key points and difficulties of the emergency landslide treatment of oil and gas ...
Min ZHANG, Ling ZHOU, Chao TAN, Zhonglin LIAO, Yong HE   +4 more
doaj   +1 more source

Determination of the Anchorage Depth of Rigid Anti-Slide Piles Based on Biparameter Method

, 2011
In order to improve the design and calculation of anti-slide piles, the design method is proposed which can calculate anchorage depth of rigid piles based on bi-parameter mode of foundation coefficient and the corresponding formula is deduced in details.
Yan Zhi Wu
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Model tests and numerical analysis of slopes reinforced by short anti-sliding piles

Yantu gongcheng xuebao, 2020
As an active protective structure for landslide prevention, the short anti-sliding piles have been gradually developed and applied in the engineering field. However, this kind of structure is only suitable for landslides where the strength of the sliding
ZENG Hong-yan 1, 2, HAN Li-biao 1, 2, ZHOU Cheng 1, 2, LIU Wei 1, 2, TAN Chang-ming 3
doaj   +1 more source

Stability Investigation of Contiguous Replacement Piles.

Zanco Journal of Pure and Applied Sciences, 2023
Urbanization leads to increase lands cost which resulted in the construction of high towering vertically toward the sky and use underground for construction. Foundations of these structures need deep excavation. Anti-slide piles are a suitable option for
Hangaw Najm Ahmed ,Yousif Ismael Mawlood
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

The Dynamic Responses of Anti-Slide Piles Reinforced in the Rubble Soil Landslide

, 2011
Acoording to the servic eability limit state, use the numerical analysis the method, using the fiinte element analysis software to the elastoplastic and the big distortion on the power solidifies in the finite element model, by using above coupled non ...
Qiang Cai, Yun Cui, Ji Ming Kong, Feng Sun, Fa You A   +4 more
core   +1 more source