Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Neoliberalism is not dead - On political implications of Covid-19. [PDF]
Cap Class, 2021 Šumonja M.
europepmc +1 more source
Advanced Science, EarlyView.A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi +6 more
wiley +1 more source
The State of Exception Between Schmitt and Agamben: On Topographies of Exceptionalism and the Constitutionality of COVID Quarantine Measures (with Examples from the Irish Context). [PDF]
Society, 2023 MagShamhráin R.
europepmc +1 more source
Advanced Science, EarlyView.This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo +10 more
wiley +1 more source
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, EarlyView.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
From the Cancer Stage of Capitalism to the Political Principle of the Common: The Social Immune Response of "Food as Commons". [PDF]
Int J Health Policy Manag, 2021 Rose N.
europepmc +1 more source
GEOGRAPHY, ASSIMILATION, AND DIALOGUE: Universalism and Particularism in Central-European Thought [PDF]
There are many advantages and disadvantages to central locations. These have shown themselves in the long course of European history. In times of peace, there are important economic and cultural advantages (to illustrate: the present area of the Czech ...
Callaway, H. G.
core
'At the Mercy of the German Eagle': images of London in dissolution in the novels of William Le Queux [PDF]
, 2020 The works of the prolific author, William Le Queux, represent the highpoint of the German 'invasion panic' genre in the years before 1914. Widely read by contemporaries, his novels provided a catalyst for British debates about the economic, military and ...
Taylor, Antony David
core
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source