Results 111 to 120 of about 1,756 (252)
Advanced Science, EarlyView.Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Integrating Africa by Competition and Market Policy. [PDF]
Rev Ind Organ, 2022 Fox EM.
europepmc +1 more source
On the cultural analysis of social policy [PDF]
, 2005 This paper takes the increased interest in the relation between culture and social policy as a starting point, and discusses how this increasing attention can be understood as the result of economic, social and academic trends. It discusses these matters
Van Oorschot, Wim
core +1 more source
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Homeland Security vs. the Madisonian Impulse: State Building and Anti-Statism after September 11
, 2005 The shock of war is closely associated with the growth of the state, in the United States and elsewhere. Yet each proposal to significantly consolidate or expand executive power in the United States since September 11th has been resisted, refined, or even rejected outright.
Stowsky, Jay, Kroenig, Matthew
openaire +1 more source
Introduction. The final Foucault and Education [PDF]
, 2018 The emphasis of this collection of papers is on using Foucault for thinking differently about education. A distinctive feature of the contributions is to mobilise a foucauldian attitude towards the historicisation and denaturalisation of what it means to
Ball, Stephen J. +2 more
core
Advanced Science, EarlyView.This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Homogenizing nationalists, budding fascists, and truculent exceptionalists: the end of world order in the Indo-Pacific. [PDF]
Int Polit (Hague), 2022 McKinney JM.
europepmc +1 more source