Results 21 to 30 of about 1,438,843 (259)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Fórum LinguísticoIn this article, the author draws on evidence from newly emerged states’ language policy and planning in the Iranian Plateau, and its surrounding Silk Roads region, in order to illustrate that the European nation-state model has been a major cause of ...
Amir Kalan
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Globalization and governance: from statism to polycentrism [PDF]
, 2004 This paper explores the implications of globalization for governance. It argues that the contemporary large-scale and accelerated growth of transworld connectivity has rendered the statist mode of governance unviable and encouraged the emergence of ...
Scholte, Jan Aart, Jan Aart Scholte
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
S: I. M. O. N., 2019 The Jewish Territorialists, represented as of 1934 by the Freeland League for Jewish Territorial Colonisation, searched for places of settlement for Jews outside Palestine/Israel. I here argue that Territorialist ideology demonstrated both continuity and
Laura Almagor
doaj
Is Statism an Amoral Philosophy?
, 2020 Thick moral terms – such as theft, fraud, and counterfeiting – are terms whose very use implies a definitionally necessary moral evaluation of their content.
Wiśniewski, Jakub +1 more
core +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source