Results 41 to 50 of about 1,438,843 (259)
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Modern American History, 2023 Beginning in the 1920s, a network of conservatives who sought to limit the federal government's domestic responsibilities mobilized modern persuasion techniques to belittle the government's efforts to address domestic economic and social problems. Over several decades, the conservative persuasion campaign delivered billions of messages disparaging ...
openaire +1 more source
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source
Christian Anti-Communism Crusade - Application for membership
, 1962 Christian Anti-Communism Crusade - Application for ...
Christian Anti-Communism Crusade
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Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Anti-dumping Policy and Anti-dumping Retaliation
, 2016 This paper analyzes the incentives to petition for anti-dumping protection in the context of anti-dumping retaliation. We examine how anti-dumping retaliation may arise and whether such retaliation can be a threat that dissuades a domestic firm facing ...
Chen, Chin-Sheng;Kao, Kuo-Feng +1 more
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Internationalism versus Statism and Globalism
, 2012 This chapter examines contemporary debates about statism and globalism. Statists need a necessary condition for justice to apply. They must tell us what it is about states that renders such principles applicable, and does so only in states. The quest for
Mathias Risse
core +1 more source
Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
, 1963 Christian Anti-Communism Crusade - Invitation to a lecture by Dr. F.
Christian Anti-Communism Crusade
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