Results 291 to 300 of about 396,796 (347)

Decreased multidrug resistance protein 1 and increased platelet activation in obstructive sleep apnea syndrome

open access: yesSleep Research, EarlyView.
There was a positive correlation between apnea/hypopnea index (AHI) index and platelet aggregation and a negative correlation between CD42b and multidrug resistance protein 1 (MRP1). Platelet activation was high while MRP1 expression was low in severe obstructive sleep apnea syndrome (OSAS) independent of smoking, age, and gender.
Cigdem Bayram Gurel   +8 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

A mitochondria‐targeted aggregation‐induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer

open access: yesSmart Molecules, EarlyView.
A mitochondria‐targeted AIE photosensitizer, LIQ‐TPA‐TZ, was developed to fight against Candida infection. It can efficiently produce reactive oxygen species to kill Candida guilliermondii and eradicate biofilms. It not only disrupted the respiratory chain and affected the metabolism and energy supply but also reduced the fungi adhesion and filament ...
Kun‐Mei Liu   +5 more
wiley   +1 more source

Use of Callistemon citrinus as a gastroprotective and anti-inflammatory agent on indomethacin-induced gastric ulcers in obese rats

open access: gold
Jonathan Saúl Piñón-Simental   +6 more
openalex   +1 more source

Treponema pallidum Protein Tp0136 Induces Spheroidization of Vascular Endothelial Cells, Resulting in Widened Intercellular Junctions and Enhanced Vascular Permeability

open access: yesSmall Science, EarlyView.
Treponema pallidum protein Tp0136 enhances vascular permeability by upregulating CSRP1, which induces MYO10 exon 19 skipping, reducing MYO10 expression and triggering endothelial spheroidization. This study reveals a novel RNA splicing‐mediated dissemination mechanism, proposing CSRP1/MYO10 as therapeutic targets to limit bacterial dissemination in ...
Yu Lin   +5 more
wiley   +1 more source

Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and Emerging Therapeutic Strategies. [PDF]

open access: yesBiomedicines
Dawi J   +8 more
europepmc   +1 more source

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