Results 201 to 210 of about 331,966 (252)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Chinese Patient Preferences and Trade-Offs for Therapy-Related Attributes of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema and Neovascular Age-Related Macular Degeneration: A Discrete Choice Experiment. [PDF]

Patient
Wang H, Zhang J, Li Y, Suo Y, Wang H, Gu Z, Yan H, Wang C, Shao L, Wei W, Jin X.   +10 more
europepmc   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

Effect of intrapleural anti-Vascular Endothelial Growth Factor (VEGF) associated with nab paclitaxel in a murine model of malignant pleural effusion. [PDF]

BMC Cancer
Silva CSR, Teixeira LR, Pereira KR, Figueiredo Braga Colares P, Alvarenga VA, Sales RKB, Roque AC, Marchi E, Mamoni RL, Pagliarelli Acencio MM.   +9 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema in Türkiye: 48-Month Data, BOSPHORUS-DME Study Group Report No. 1. [PDF]

Turk J Ophthalmol
Özal E, Özkaya A, Arıcı M, Korkmaz A, Ermiş S, Çiloğlu Hayat Ş, Karapapak M, Özal SA, Çakır A, Karataş G, Yıldız D, Erdoğan M, Koçak İ, Sayın N, Karabaş VL, Önder Tokuç E, Tiryaki Demir S, Karataş ME, Uçak T, Öztürk M, Demirayak B, Onur İU, Hepokur M.   +22 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Intraocular Pressure After Anti-Vascular Endothelial Growth Factor Injection in Eyes With a Mineralized Bruch's Membrane Caused by Pseudoxanthoma Elasticum. [PDF]

Invest Ophthalmol Vis Sci
Raming K, Saltenberger I, Meinke J, Risseeuw S, Mercieca K, Herrmann P, Chang P, Ach T, van Leeuwen R, Ossewaarde-van Norel J, Pfau M, Holz FG, Pfau K.   +12 more
europepmc   +1 more source

"Attenuated" Pulmonary Tumor Thrombotic Microangiopathy on Anti-Vascular Endothelial Growth Factor Treatment: A Case Report. [PDF]

Case Rep Oncol
Ozaki H, Yamaguchi T, Kizawa R, Tanabe Y, Suyama K, Miura Y.   +5 more
europepmc   +1 more source

Early Pars Plana Vitrectomy and Anti-vascular Endothelial Growth Factor (VEGF) in the Management of Terson Syndrome: A Case Linked to Methicillin-Resistant Staphylococcus aureus (MRSA) Meningitis. [PDF]

Cureus
Ağın A, Karaca D, Kilic S, Onder F.
europepmc   +1 more source