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Biomaterials, 2018 Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting.
Hyun Joo An +2 more
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Anti-VEGF and Retinal Dystrophies
Current Drug Targets, 2020The therapeutic approach based on anti-vascular endothelial growth factor (anti-VEGF) molecules can be used to treat two important complications of retinal dystrophies: choroidal neovascularization and macular edema. The macular involvement in retinal dystrophies can lead to further visual deterioration in patients at a young age and already affected
Battaglia Parodi Maurizio +2 more
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Resistance to Anti-VEGF Agents
Current Pharmaceutical Design, 2004The number of anti-angiogenic agents developed for clinical use has risen greatly over the past decade. Currently, more than 80 are in trials ranging from phase I through to phase III studies and many more are in preclinical evaluation. Much hope was envisaged for these new agents to become the panacea of anti-tumoural treatment.
Ton, N. C. +1 more
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Anti-VEGF therapy for glaucoma
Current Opinion in Ophthalmology, 2010The role of antivascular endothelial growth factor (anti-VEGF) agents in treating various ophthalmic diseases is currently being investigated. There have been many advances in the understanding of how anti-VEGF agents work and speculation on when to implement them clinically for neovascular glaucoma.
Michael B, Horsley, Malik Y, Kahook
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2021
In the current management of ROP, anti-VEGF drugs have a very significant role. These drugs can be used in ROP in different clinical situations: as a primary treatment for posterior ROP, for progressing cases after they have been previously treated either with a laser or with an anti-VEGF drug, and as an adjunct in ROP-related vitreoretinal surgery ...
Andrés Kychenthal, Paola Dorta
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In the current management of ROP, anti-VEGF drugs have a very significant role. These drugs can be used in ROP in different clinical situations: as a primary treatment for posterior ROP, for progressing cases after they have been previously treated either with a laser or with an anti-VEGF drug, and as an adjunct in ROP-related vitreoretinal surgery ...
Andrés Kychenthal, Paola Dorta
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Anti-VEGF Treatment of Corneal Neovascularization
Ocular Surface, 2011Vascular endothelial growth factor (VEGF) is an angiogenic factor shown to be a critical secreted cytokine in tumorigenesis and retinal neovascularization (NV). Currently, there are two anti-VEGF agents, pegaptanib and ranizumab, approved by the United States Food and Drug Administration (FDA) for intravitreal use in the treatment of wet age-related ...
Deborah Jacobs
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Anti-VEGF therapy for diabetic retinopathy
Vestnik oftal'mologii, 2021Diabetic retinopathy (DR) is one of the most severe complications of diabetes mellitus, its treatment involves specialists of different areas - endocrinologists, diabetes specialists, therapists, cardiologists, surgeons, anesthesiologists etc. For ophthalmologists the objective is to diagnose ocular pathological changes associated with diabetes ...
E S, Chekhonin +3 more
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Acta Ophthalmologica, 2014
AbstractThe diabetic macular edema (DME) related to visual loss, results mainly from changes in the affected blood‐retina barrier. VEGF, originally described as vascular permeability factor, is considered not only as a critical stimulus of retinal neovascularization but also as the primary inducer of increased vascular permeability involved in the ...
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AbstractThe diabetic macular edema (DME) related to visual loss, results mainly from changes in the affected blood‐retina barrier. VEGF, originally described as vascular permeability factor, is considered not only as a critical stimulus of retinal neovascularization but also as the primary inducer of increased vascular permeability involved in the ...
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Anti-VEGF and intraocular pressure
British Journal of Ophthalmology, 2011It is with great interest that I read the article by Good and associates1 on sustained elevation of intraocular pressure (IOP) after anti-vascular endothelial growth factor (VEGF) injections. Though several authors have observed raised IOP after intravitreal injections,2–6 this study assumes great importance since the authors have tried to identify ...
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Therapeutic Anti-VEGF Antibodies
2008Vascular endothelial growth factor (VEGF-A) is a key cytokine in the development of normal blood vessels as well as the development of vessels in tumors and other tissues undergoing abnormal angiogenesis. Here, we review the molecular engineering of two humanized antibodies derived from a common mouse anti-VEGF antibody--bevacizumab, a full-length IgG1
S, Lien, H B, Lowman
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