Results 11 to 20 of about 100,511 (312)

Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity

Journal of Ginseng Research, 2020
Background: Malignant arrhythmias require drug therapy. However, most of the currently available antiarrhythmic drugs have significant side effects. Ginsenoside Rg2 exhibits excellent cardioprotective effects and appears to be a promising candidate for ...
Dongxia Gou, Xuejing Pei, Jiao Wang, Yue Wang, Chenxing Hu, Chengcheng Song, Sisi Cui, Yifa Zhou   +7 more
doaj   +2 more sources

Flecainide‐Induced Interstitial Lung Disease: A Case Report and Review of the Literature

Clinical Case Reports
This case describes a rare adverse effect in which the subject developed interstitial lung disease after initiating a class IC antiarrhythmic, flecainide.
Elizabeth Jenkins, John McGinty, Brian Skinner   +2 more
doaj   +2 more sources

Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia.

Journal of the American College of Cardiology, 2022
BACKGROUND In patients with ischemic cardiomyopathy and an implantable cardioverter-defibrillator (ICD), catheter ablation and antiarrhythmic drugs (AADs) reduce ICD shocks, but the most effective approach remains uncertain.
Á. Arenal, P. Ávila, J. Jimenez-Candil, L. Tercedor, D. Calvo, F. Arribas, J. Fernández-Portales, J. Merino, A. Hernández–Madrid, F. Fernández‐Avilés, A. Berruezo   +10 more
semanticscholar   +1 more source

Recent Advances in Antiarrhythmic Drug Therapy

Drugs, 2023
Cardiac arrhythmias remain a common cause of death and disability. Antiarrhythmic drugs (AADs) and antiarrhythmic agents remain a cornerstone of current cardiac arrhythmia management, despite moderate efficacy and the potential for significant adverse ...
A. Saljic, J. Heijman, D. Dobrev
semanticscholar   +1 more source

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine.

Angewandte Chemie, 2021
Na v 1.5, the primary voltage-gated Na + (Na v ) channel in heart, is a major target for class I antiarrhythmic agents. Here we present the cryo-EM structure of full-length human Na v 1.5 bound to quinidine, a class Ia antiarrhythmic drug, at 3.3 Å ...
Zhangqiang Li, Xueqin Jin, Tong Wu, Gaoxingyu Huang, Kun Wu, J. Lei, Xiaojing Pan, N. Yan   +7 more
semanticscholar   +1 more source

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

International Journal of Molecular Sciences, 2022
Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex mechanisms that differ between subgroups of patients.
A. Saljic, J. Heijman, D. Dobrev
semanticscholar   +1 more source

SGLT2 Inhibitors and Their Antiarrhythmic Properties

International Journal of Molecular Sciences, 2022
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are gaining ground as standard therapy for heart failure with a class-I recommendation in the recently updated heart failure guidelines from the European Society of Cardiology.
E. Kolesnik, D. Scherr, U. Rohrer, M. Benedikt, M. Manninger, H. Sourij, D. von Lewinski   +6 more
semanticscholar   +1 more source

The Blinding Period Following Ablation Therapy for Atrial Fibrillation: Proarrhythmic and Antiarrhythmic Pathophysiological Mechanisms.

JACC Clinical Electrophysiology, 2021
Atrial fibrillation (AF) causes heart failure, ischemic strokes, and poor quality of life. The number of patients with AF is estimated to increase to 18 million in Europe in 2050. Pharmacological therapy does not cure AF in all patients.
L. Gottlieb, L. Dekker, R. Coronel
semanticscholar   +1 more source

Utilization of Pharmacokinetic/Pharmacodynamic Modeling in Pharmacoepidemiological Studies: A Systematic Review on Antiarrhythmic and Glucose-Lowering Medicines

Frontiers in Pharmacology, 2022
Introduction: In human pharmacology, there are two important scientific branches: clinical pharmacology and pharmacoepidemiology. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is important in preclinical studies and randomized control trials. However,
Soroush Mohammadi Jouabadi, Soroush Mohammadi Jouabadi, Mitra Nekouei Shahraki, Payam Peymani, Bruno H. Stricker, Fariba Ahmadizar, Fariba Ahmadizar   +6 more
doaj   +1 more source

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain.
D. Packer, D. B. Mark, R. Robb, K. Monahan, T. Bahnson, J. Poole, P. Noseworthy, Y. Rosenberg, N. Jeffries, L. Mitchell, G. Flaker, E. Pokushalov, A. Romanov, T. Bunch, G. Noelker, A. Ardashev, A. Revishvili, D. Wilber, R. Cappato, K. Kuck, G. Hindricks, D. W. Davies, P. Kowey, G. Naccarelli, J. Reiffel, J. Piccini, A. Silverstein, H. Al-Khalidi, Kerry L Lee   +28 more
semanticscholar   +1 more source